READERS SUMMARY: 1. WHAT ARE THE EVOLUTIONARY IMPLICATIONS OF A LEAKY GUT AS A POSITIVE ADAPTATION AT OUR SPECIES ORIGIN? 2. WHY DID BIPEDALISM ARISE BEFORE BRAINS IN HUMANS? 3. DID THE CLIMATE AND TECTONIC PLATES DICTATE THE EPIGENETIC CHANGES IN THOSE TRANSITIONAL PRIMATES? 4. DID RAPID CHANGES IN INNATE AND CELL MEDIATED IMMUNITY OCCUR BEFORE THE BODY PLAN CHANGES IN PRIMATES? When our ancestor primates acquired this leaky gut mentioned in the last blog Brain Gut 2, it allowed them to assimilate a lot of new genetic material that would help them navigate their new surroundings. This genetic material was assimilated very quickly and in a short amount of time. Why do I say this? In the East African Rift during ‘homo’ speciation their was massive climate change. In times of environmental change species are subjected to something called punctuated equilibrium. This theory states for most of evolutionary time species are in an equilibrium with their environment and then something sudden happens to force adaptation. We saw this in the K-T event, the Young Dryas, and when primates evolved to humans during the late Pilocene. It appears that by studying the difference between primates and human DNA weContinue Reading
BRAIN GUT 2: VIRAL MARKETING
READERS SUMMARY: 1. To discover the unknown we must use the known to guide our thoughts to see the future. 2. How should we think about evolution and health now? Counterintuitive is an axiomatic cognitive ability required for neurosurgical residency training and that is why I chose to tackle this problem in this fashion. 3. If we want to explore the mystery of our clade we need to go back to the things that separate us from them that we know to be true today. The knowns are that our EQ (encephalization quotient) exploded rapidly. WHY? 4. Is our past really our new prologue? Todays blog is to show you how Factor X was made actionable in bring man from ape. Most of you know, I believe it was due to a faster epigenetic plan that altered the mammalian body plan. What most do not know it was the result of viral marketing. This is not the viral marketing of today’s social media platform. This is where viral marketing was truly invented. First created in our oceans, and eventually incorporated into the DNA of life. Do you think this hyperbole? One drop of sea water has a million bacteriaContinue Reading
CPC #5 THE LEAKY GUT/ADRENAL FATIGUE CASE
READERS SUMMARY: HOW CAN A LEAKY GUT CAUSE ADRENAL FATIGUE? CAN OTHER THINGS COMPLICATE THIS LIKE A VIRAL INFECTION? CAN WE TREAT IT? HOW DO WE TREAT IT? CAN YOU HOPE FOR IMPROVEMENT TOO? A PATIENT TESTIMONIAL AFTER JUST 4 MONTHS OF TREATMENT We have talked at length on my forum about how a leaky gut can cause havoc for modern humans. What many people do not realize is that humans having a leaky gut happened by design. Primates, our nearest relatives, do not have leaky guts by design because they do not have zonulin the protein that binds our gut cell membranes where they join. Many people are shocked to find out that this make it impossible for a Primate to get an autoimmune disease. This is also true. Primates also can’t get an infection of H. Pylori in their guts either. This is why Barry Marshall had to drink a vat of H. Pylori to prove it caused human ulcer disease in the last part of the 20th century. He had no animal models that would prove his hypothesis. Check out this detailed history of precisely what the establishment did to Dr. Marshall and his ideas for closeContinue Reading
E=MC2: MAKING FACTOR X ACTIONABLE
READERS SUMMARY: 1. How does the fossil record prove that epigenetics is the most dominant factor in biology today? 2. How does this lack of insight create a huge mismatch for patients trying to get to Optimal? 3. Does epigenetics change they way we think? 4. Does the way we think alter our biology and can it alter the medicine we practice? 5. How do we make this actionable for patients? In the famous equation E=mc2 we all know that the speed of light is the most important variable in the power of the equation. This has become the logical syntax of science the last 100 years. This is why a nuclear weapon has the energy it does from two small blocks of metals that get exploded into us. The equation is now being challenged by new wave scientists. In fact, one of them spoke at the TEDx Nashville event I participated in and I found his talk fascination on many levels. I love people who challenge scientific dogma. Might there be a similar ‘weighted or squared factor’ in biology that does the same thing to a biologic system? Might that one factor have the same magnitude on modern man?Continue Reading
CPC#4 EVOLUTIONARY FRIEND OR FOE?
READERS SUMMARY: WHY IS IRON IMPORTANT? HOW DOES IT AFFECT LIFE AT A 30ft LEVEL MICROSCOPICALLY HOW DOES IT AFFECT LIFE AT A 30,000 ft LEVEL IN OUR OCEANS HOW DID EVOLUTION USE IRON TO PROTECT US AND OUR SPECIES? HOW DID A PROTECTIVE EFFECT BECOME A DEADLY DISEASE IN 50 YEARS RIGHT UNDER OUR NOSES? IS THIS ALL TIED TO FACTOR X TOO AT SOME LEVEL? This blog was specifically designed for the people who just experienced my Factor X Webinar unveiling so it may not make total sense to those who did not attend. For those who did attend you now have the context to understand the following “few modern diseases” that just may not be diseases at all because of how an evolutionary bottle neck sped up epigenetics. HEMOCHROMATOSIS: Iron is a element that is vital for life. In fact, every form of life on this planet uses it to some degree to make sense out of the random chaos of the chemistry of atoms that life orders together to make the beautiful musical composition that is life. For humans, metabolism requires Iron. Iron carries oxygen to tissues in our cells but it can paradoxically makeContinue Reading
WHY PERSPECTIVE MATTERS?
READERS SUMMARY: 1. CIRCADIAN BIOLOGY NEEDS TO BE YOUR BIGGEST CONCERN AND NOT YOUR FOOD 2. WHY HAVING AN EVOLUTIONARY ADVANCED BRAIN MAYBE A DETRIMENT AT TIMES 3. THINK ABOUT WHY YOU FEEL AND THINK THE WAY YOU DO BEFORE YOU DO SOMETHING 4. THINK ABOUT WHAT IS SAFE BEFORE YOU EAT IT 5. CHANGING YOUR PERSPECTIVE MAY OPEN YOUR MIND TO NEW POSSIBILITIES FOR YOUR STALLS Circadian biology is so fundamental to sleep and metabolism but few people realize just how important it really is. It is more important than your macro or micronutrients. Most of you reading this really do not buy this because of the questions I get asked and all the comments I have seen made on FB, twitter, blogs, and on internet forums. The blogosphere is tied to macronutrient ratios. It is a fact that our neolithic mind has burned into our conscious beliefs. This post is about showing you why you might want to consider changing your perspective on things related to what you eat. What you feel like eating does not mean it should be what you are designed to eat. What you can eat safely, does not mean it should be what we are designedContinue Reading
THE "TEETH" IN DISEASE?
READERS SUMMARY: 1. HOW SCIENCE PRESENTS A CURVEBALL YOU DID NOT SEE COMING? 2. HOW YOUR MOUTH MIGHT BE THE KEY TO DIABETES, OBESITY AND INFLAMMATION? 3. IS THERE A HYPOTHALAMIC PAROTID AXIS? 4. IS THE PAROTID GLAND THE MOUTH’S PANCREAS? Most of you may not know that before I was a neurosurgeon, I was a dentist and oral and maxillofacial surgeon. Many people know that Weston A. Price was a dentist too, who was ostracized from organized dentistry for many political reasons. Much of his accomplishments have been largely under appreciated ,because he was painted as an “renegade” by the American Dental Association and by organized dentistry. Most dental students never learn a thing about him or his work as a result. The paleo community knows about Weston A. Price largely, because of his foundation and people like Sally Fallon and the newer generation of young bucks, like future PHd, Chris Masterjohn. When I went to dental school at UCONN, my classmates and I never learned a thing about Weston A Price. We never were told about his work or his books. In the last 25 years, my education has evolved from dentistry to oral surgery, then toContinue Reading
AVOIDING FATES OF RONALD REAGAN OR MICHAEL J FOX.
READERS SUMMARY: 1. Why the presence of genes means nothing to disease risk. 2. What do people over 100 years old teach us about genetics? 3. What six pieces of evidence found in 2011 tell us about AD or PD etiology? 4. How will industry try to solve the mystery? 5. What you can do right now to obliterate your current risk of AD and PD? If you did not know that Ronald Reagan suffered and died from end stage Alzheimer’s, you do now. Micheal J. Fox is afflicted with Parkinson’s disease and trying to solve its etiology as a fundraiser. Recently in 2011, several announcements were made that several genetic mutations seem to predispose us to Alzheimer’s disease (AD) and Parkinson’s Disease (PD). I tend to glance over these findings often because based upon my current understanding, genetic mutations are not where science seems to be headed these days. Genetic determinism has been the dogma for the last 50 years, but the most recent data suggest that we can reprogram our genes by turning on and off their function if we know how. This makes sense considering that most biologic systems don’t rely on the presence or absence ofContinue Reading
DEVELOPMENTAL ORIGINS OF DISEASE
The basis of epigenetics is founded in fetal development and is heavily influenced by grand maternal and maternal behaviors that influence in utero life of the fetus. This influence seems to be multigenerational as well because of the inheritance of meiotic stem cells in females. It has been known for years that the mother’s behavior during pregnancy clearly effects the child’s outcomes when born. The extent of this effect however has never been studied in depth until recently. It appears that the mother’s diet, metabolism, and exercise status during pregnancy has profound effects on the fetus and likely set the “epigenetic switches” on the child’s DNA. These changes seem to set the child up for neolithic diseases and the chronic diseases we see in America today. For the last thirty years childhood obesity studies have shown a dramatic change in NHANES curves that measure obesity in children. We now see young children and infants with chronic diseases that adults used to get later in their life. Most of the focus of researchers in childhood obesity, like Robert Lustig, have focused in on postnatal environmental factors in childhood as the major cause. He views fructose consumption as a major culprit inContinue Reading
