ARE YOU AWARE THAT YOU CAN EASILY CHANGE YOU METABOLISM BY YOURSELF AT HOME?
DO YOU KNOW THAT YOU CAN CHANGE YOUR CALORIE NEEDS TOO?
ARE YOU AMBIENTLY AWARE OF WHAT YOU DO NOT KNOW, BECAUSE YOU HAVE NOT CONSIDERED IT?
CONSIDER THREE NEW RADICAL RULES THAT MIGHT INTRIGUE YOU TO KNOW MORE ABOUT CT
Now that you understand that I believe cold environments were how life first evolved, what implications does this hold for all life and humans today? I think with this thought experiment we need to begin to talk about another aspect of evolution to fully conceptualize how cold works for biology. Let’s talk about sleep for 4 short minutes. First, I want you to watch this video before you proceed.
Recently, one of my readers pointed out he was confused by Dr. Gamble when she said the normal pattern of sleep in a natural environment had two cycles. He wanted to know why her version and my version for sleep as written in my post “Rx for the Leptin Rx” were not congruent. It was a great question that really opens the discussion to the idea of evolutionary mismatches. These mismatches occur in many modern systems of biology, and they are actually increasing in frequency and severity as time elapses. The reason is quite simple. Evolution is constantly getting faster as time goes on, relative to the current state of our genome. This is really how the “cellular theory of relativity” is currently affecting our own genome today. The speed of evolutionary change has far out stripped the ability of our paleolithic genes to catch up. This mismatch causes major problems for modern humans. When they further exacerbate the system with choices not congruent with our biology, the results are magnified in disease incidence and prevalence.
She also mentioned in passing, early in her talk, that people who went deep into the ground have been found to be “very productive” while in a cold dark environment. She did not expand on this concept at all, but I would strongly suggest you remember this as the cold thermogenesis series progresses on. There is a deep biologic reason this occurs. As we use this pathway, lots of things improve that we do not expect.
She assumed in her talk that native polar people without artificial light sleep differently than we do today. She spoke about the effect of light cycles. She said that she felt that light cycle were the most important affect on our biology. Light cycles are important to all life, but this bright researcher is apparently unaware that mammals have an innate ability to change their internal chemical clocks when their environment changes.
We stop using the photic light cycles to yoke metabolism to our sleep when it is cold. There is an epigenetic switch in us that stops our suprachiasmatic nucleus from using light in cold environments. This is done by design by evolution because light cycles do not become important in freezing cold because carbohydrates cannot grow in these environments. So evolution designed a plan to teach mammals who cannot think as we can that the best way to yoke the season cycles at our poles is to use temperature instead. That is precisely what happens. I will explain the complex biochemistry later in the series and provide you with cites. Right now, I want you to be aware of this metabolic trap door. Its mere presence is shocking enough. But its implications are far greater for modern humans.
There is one larger problem with her assumptions in this TED talk. She said light is the big deal. And I know it is not true any longer in cold. This means that if evolutionary biology gave up on light and uses cold, what else may happen to our metabolism in cold? Evolution does not do these things for no reason. She was quick to point out that this ability has been lost in modern humans in her estimation because of our discovery and widespread use of artificial light has become a huge game changer. We know Paris, France became the first city in our world that used fake light in 1924. I think most humans are not really aware of how basic circadian mismatches destroy our biology slowly via the “slow erosion of metabolic function.”
We know that humans die most from heart disease and heart failure. Heart failure is the number one cause of admission according to Medicare data. After this blog is through, you might know why this makes complete sense. The reason has to with a slow erosion of the process of autophagy in humans due to the circadian mismatches created by our choices in life when they are married to the rapidity to the development of our neolithic brain. In essence, we got so smart so fast we became able to control too much of our environment for our own epigenetic and genetic good. The smarter we got, the more mismatches we created for our biology and the less efficient autophagy became to fix and recycle proteins for repair. Reduced autophagy leads to heart failure. So this means that biologic mismatches are best measured in animals by looking at their rates of heart failure. For humans, the rates are staggering. That is a big clue that what we all believe to be true could be what is actually killing us slowly. Remember autophagy occurs when we sleep.
Moreover, when one looks at the biology and biochemistry of sleep and truly understands the power of autophagy for longevity, it becomes apparent that we may want to consider that maybe sleep is our primordial condition and not wakefulness. Maybe, just maybe, we evolved consciousness over time. This theory I have follows the thoughts I have developed in my cold thermogenesis theory, because in extreme cold environments, the process of autophagy becomes “super sensitized” to save energy while it increases our metabolic capabilities. Remember when Jessa Gamble said that humans in dark deep holes become more energized and productive in her TED talk? The reason why is cold dark environments super sensitize the human process of autophagy without us actually having to sleep at all. The cause is an increased efficiency of autophagy by cold and dark. The metabolic trap door does something to us that we cannot do in long light cycles. To get suprasensitive autophagy in light we have to sleep well. This is an example of how metabolism and biochemistry can rewire or become thermoplastic in cold and dark environments.
In fact, in cold, sleep is heavily selected for in terms of how mammalian nervous systems are built by evolutionary design. Cold stimulus changes the behavior or eutherian mammals. This is why mammals can sleep so long underground in sub zero conditions and survive. Sleep is heavily selected for in cold.
Radical Rule #3: Sleep and cold environments were our ancestor’s primordial condition and as such, this was evolutions starting point for life on our planet.
Sounds more radical does it not? Let’s consider these thoughts and facts today.
If we assume this to be true, this thought explains why epigenetics has been found as the dominant player in how genetics operate in biology. Why? Anything that promotes survival and reproductive fitness has to be passed to the next generations. This is evolutions main directive. I think evolution found that epigenetic modifications to be quite effective way to pass on environmental information to succeeding generations. So successful, that it became a backbone law of genomic functioning. Evolution follows fractal patterning. So it is also highly conserved in all species. Today that appears to be true too. Life at its genesis was likely static, and to get the nutrients it needed, it used passive diffusion because of proximity. This made food scarce to life at all times. To survive it had to overcome this impedance. This manner of nutrient collection is highly inefficient, but the suprasensitivity of autphagy in cold made the process biologically plausible for great part of our evolutionary history. It appears that evolution naturally adapted to improve access to nutrients and to do so, it had to evolve wakefulness to obtain them. Yes, you read that correctly. To complete this, it yoked metabolism to sleep early on in evolutionary biology so it could account best for nutrients and autophagic repair to lead to optimal survival. I believe the use of timing became an easy evolutionary solution because of the rhythm of the sun and the freezing cold that these cells found them in could account for these cycles.
I believe that fractal organization of sleep and metabolism remains in every organism studied today. If you ask sleep researchers, (I have) they have told me this is a correct assumption. I believe that sleep and autophagic efficiencies are extremely high conserved across all species on our planet. We still have yet to find a species that does not sleep some. I think as life evolved wakefulness and not sleep, because it had to account for its environment. Such evolution then moved from a static model to a dynamic one, and then a whole new set of environmental problems had to be navigated to make life persist. Now you see why autophagy sits at position 15 on the Quilt. It is a critical component of optimal living in all species, not just our own.
This also signals where movement was first coupled to memory or actions in life. Even today, all learning in higher order animals is directly coupled to movement in their environment. The more one moves, the more intelligent one becomes. I just explained that to you in a recent blog on here.
We can prove this today because if we just get an Alzheimer’s patient with a demolished brain, when we introduce exercise, we can increase their cognitive function in a completely broken organ. In fact, in any neurodegenerative condition this happens by evolutionary design. That tells me a lot of how “evolution thinks”. The more I learn how she thinks, the more I learn. I hope this helps you understand how I think about life and how it all began. It is a foundational concept behind my QUILT document. When you see my point of reference, you begin to see a new reality that you might have not anticipated before.
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