ORGANIZATIONAL STRUCTURAL FAILURE # 5 PRIONS ARE COMPLIANT DESIGN FLAWS

READERS SUMMARY 1.  How do prions cause disease? 2. How does light in the brain work? 3. Why red light is critical in the brain? 4.  How does Fronto-temporal dysplasia and Gliobastoma multiforman link together from a prion point of view? 5.  How do all these  neurologic and mental diseases link directly back to the gut?     Today in part two of our prion blog, you are going to learn the single most important function of life’s design using quantum biology is shape adaptation in both proteins and in DNA. Shape change dictates tissue optics and tissue optics are all tied to the proper thermodynamic view of life. The reason now should be intuitive. Any changes in geometry alters energy profiles and physiologic function. The innate ability to alter protein geometry in real time enables nature’s machines to operate with the utmost efficiency. Cells and tissues allow us to morph proteins to allow life to happen properly. When we do it incorrectly, disease and death emerges. It is not hard to understand……it is just hard to believe. We do it by altering atoms using electrons and photons to move their shapes. Electrons and protons are made from leptons and […]

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Energy and Epigenetics 8: Quantum Autism

Thirty years ago, autism affected 1 in 500 children. In recent years, scientists have made extraordinary advances in understanding the causes of autism. Autism now is estimated to afflict 1 in 88 children in the USA. In certain parts of the USA, it is found in 1 in 44 births. But remarkably little of this understanding has percolated into popular awareness, which often remains fixated on vaccination linkage to the disease.

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Energy and Epigenetics 7: The Epigenetic Toolbox

The human genome is the first draft of what we might be, but our life experience within the environment we choose to exist is where the final draft of our book is written. An architect far smarter than us has given us that epigenetic toolbox, and we now have the ability to use it by altering our behaviors to change our lives and reverse diseases.

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Energy and Epigenetics 4: Light, Water, Magnetism

Today’s blog post is about the three laws of nature for all life anywhere on our planet. These are axiomatic laws not subject to debate, research or your beliefs. All decisions that life has made revolve around these three things. Reducing things to these three things is simple, but the application in how life and evolution has done it is very complex. Today, we begin to unravel the mysteries.

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Energy & Epigenetics 1: The Infant Brain is Unique

Today, we begin to examine levee’s 6, 14, and 26 in the Quilt document for the first time. We begin to show examples of these levee’s by examining how the human brain forms and functions in an infant. This example will act as an analogy to help us understand many other processes as the blog series rolls on.

There are many countervailing influences in life that on the surface confuse our intellect. They create the appearance of paradox, enigma, and myths, and mysteries. I find when we look at the world through the hull of a glass-bottom ship, to look through a kaleidoscope at the galaxies that exist on the edge of our mind, we begin to see the sense that nature makes from the chaos of the world. I like the irony that mysteries often create. Today, we are going to use some “other observations” we have all made to show you how the mysteries of our modern world might be solved asking better questions instead of settling for the answers we have been given.

The Human Infant

It is clear in modern medicine now that we can not have optimal human brain development unless we have a secure nutrient rich food supply for both mother and child. This relationship also needs to be maintained postnatally for several years after birth until neuralation is successful. It does appear in modern neurosurgery research that human brain development is programmed genetically to a certain extent, but is more malleable then we thought because of the new science findings of epigenetics. This is also more apparent in humans than other mammals because our brain is so complex that even small changes in functional regions can lead to massive clinical changes that become apparent as the child develops. Autism and spectrum disorders are a good example of this phenomena.

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Quantum Biology 12: Do We Need DNA To Tell Time?

How important is time really to life?

Imagine there is a bank account that credits your account each morning with $86,400. It carries over no balance from day to day. Every evening the bank deletes whatever part of the balance you failed to use during the day. What would you do? Draw out every cent, of course? Each of us has such a bank. It’s name is time.

Every morning, it credits you with 86,400 seconds. Every night it writes off as lost, whatever of this you have failed to invest to a good purpose. It carries over no balance. It allows no over draft. Each day it opens a new account for you. Each night it burns the remains of the day. If you fail to use the day’s deposits, the loss is yours. There is no drawing against “tomorrow.” You must live in the present on today’s deposits. Invest it so as to get from it the utmost in health, happiness and success! The clock is running! Make the most of today.

To realize the value of one year, ask a student who failed a grade. To realize the value of one month, ask a mother who has given birth to a premature baby. To realize the value of one week, ask the editor of a weekly newspaper. To realize the value of one hour, ask the lovers who are waiting to meet. To realize the value of one minute, ask a person who just missed a train. To realize the value of one second, ask someone who just avoided an accident. To realize the value of one millisecond, ask the person who won a silver medal at the Olympics.

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Quantum Biology 11: Is Their Reality, Your Reality?

“There are some people who live in a dream world, and there are some who face reality; and then there are those who turn one into the other.” – Douglas Everett

What if I were to tell you that Einstein’s “theory of relativity” is not just about time being relative to the observer. What if I told you a core set of beliefs shared by enough people could actually set up an alternative reality and force you to live by its rules. Do you think the laws of quantum mechanics could some how shed light on this? Would you believe it, if I told you I believe it?

Today, we are going to show you just how “thoughts” are quantum endocrine secretions that can do just that.

I want to introduce you to the people of Monza, Italy. In July of 2004, they outlawed round fishbowls for goldfish. When the council members were questioned by the world media about this new law, they stunned many people with their answer even further.

They said the primary reason they passed the law is that they felt that the curved glass confines of the gold fishes existence might cause them to have a distorted view of “reality”. Now on the surface, this story may not have any relevance to you, but I assure you, it does.

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CPC #7: Obesity Qualia

Qualia is defined by some as “an unfamiliar term for something that could not be more familiar to each of us: the ways things seem to us.”

Erwin Schrödinger was a famous quantum physicist, and had this counter-materialist take on what qualia really is:

“The sensation of color cannot be accounted for by the physicist’s objective picture of light-waves. Could the physiologist account for it, if he had fuller knowledge than he has of the processes in the retina and the nervous processes set up by them in the optical nerve bundles and in the brain? I do not think so.”

Schrodinger’s statement is hinting at precisely what is ailing the modern sciences in a big way. Observations and the manner in which we study things are being divorced from one another. It is as if all scientist have been trained to think only with their left brain and just ignore the creative observations of their right brain. The problem with this situation is that is has put 50 years of mankind at serious risk in medicine.

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Quantum Biology 10: Hormones 102

Two years ago I gave you the Hormone 101: Clinical thoughts revealed blog post. That was a small dose of reality at the beginning of this journey. There was some foundational hormone biochemistry there given to you in simple terms. Most people jumped all over the free T3 link to pregnenolone in the post. They thought that “their cure” for hypothyroidism and/or chronic pregnenolone steal syndrome was increasing free T3 or just lowering reverse T3 to raise pregnenolone. So what was not observed?

A trip down memory lane for the hormone cascade

Leptin resistance occurs first in the brain. Then insulin resistance happens soon their after in the liver, gut, and peripheral tissues. This eventually leads to adrenal resistance. This resistance occurs at the PVN in the brain. (Brain Gut 16: Adrenal Fatigue Rx) It does not happen in the adrenal gland. What happens is that the outflow from our sympathetic system in the brainstem overwhelms the parasympathetic nervous system. This increase in overall cortisol initially, is the stress hormone that allows for fight or flight syndrome (life or death). As this condition persists chronically over time, cortisol levels decrease and flatline on adrenal stress index testing.

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CPC #6: Pseudotumor Cerebri

It has been close toa year that we last did a CPC blog post. (CPC #5 The Leaky Gut/Adrenal Fatigue Case) CPC stands for a clinico-pathologic conference that we often see in medical schools that our used for teaching students and doctors.

Today we are going to talk about a disease that has perplexed medicine for hundreds of years. Pseudotumor cerebri is also known as idiopathic intracranial hypertension (IIH) today. It goes by many names in the literature. I have decided to discuss this disease because it highlights many of the cornerstone principles of how quantum electrodynamic theory affect water chemistry. This change in water chemistry can lead to biologic effects. The biologic effects of water can be seen in modern humans when we look for them and correctly observe what is really going on. So today we see how the macrocosm affects the microcosm of a modern disease.

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EMF 2: Einstein, Meet Leptin

“You’ve got to work at living… when 99% of the globe works at dying daily; Denial of the truth will lead you into blind alleys. Let go of your paradigm, accept what nature designed, and embrace your ultimate potential” -Gretchen Bronson (starfish)
Why is the clock the most important part of the story of life?

Have you ever had a dream that seems so large in scope, it just seems like it just possibly cannot come to fruition? I have for the last 7 years. Today, I am going to share it with you.

It is time. I believe all dreams come true, if we have the courage to pursue them. It is always easier to make a dollar off a dream, but it is a lot tougher to make a difference with one. I think EMF-2, is going to do just that for everyone.

I told you all last March, on Sean Croxton’s underground internet radio show, and at Paleo FX 2012, that environmental mismatches all cause inflammation. Many of you found it a bold and interesting statement, but I never told you WHY. The reason I did not, was because I did not feel you were ready to understand my perspective, yet. Today that changes. When you do not understand someone’s perspective often times what they say sometimes sounds a bit ‘bizarre’ to you. The reason it does is because you have no frame of reference for understanding, primarily because you were never taught that space/time, might be the most critical factor in understanding trans-generational epigenetic biology today. That is going to change today as well.

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Brain Gut 9: What Really Killed Michael Jackson

Today, we are going to dive into the gut flora story a bit deeper than we did in our first gut flora post to help you understand how a a change in gut flora might lead to changes in your health by altering your hormone panel. Obesity is an inflammatory brain condition. Where does the infection come from? The gut flora actually is what causes humans to become fat. It has to due with shear numbers and the species of bacteria in our gut. There is a particular flora that produces adiposity and obesity in humans. These bacteria make something called FIAF (Fasting induced adipose factor) that control this process. This factor blocks lipoprotein lipase (LPL) in fat cells. LPL allows us to convert dietary Free Fatty Acids carried in lipoproteins into neutral fats that are stored in adipocytes.

Non Geeks: Our gut bacteria makes humans fat.

Geek Alert: The FIAF is made by our liver, muscles, and our small bowel wall when food sources are in short supply. This is the signal to stop storing fat in our fat cells when food is scarce. What is not well appreciated by many is that the FIAF in our intestinal wall is controlled 100% by our gut flora. When we have a simplified gut flora it favors fat cell creation. When our gut flora is complex and healthy, it has 100 trillion cells with 250 species. We tend not to make fat in this instance either! Moreover, when the bacteria are active metabolically due to the presence of simple sugars, production of FIAF ceases, and fat creation is signaled. This implies that our gut flora is directly tied to fat creation in humans. The gut flora’s action is directly signaled to the brain via the afferent nerve fibers in the vagus nerve. In those newly created fat cells, a protein called leptin is also produced, and acts as a score keeper for the brain of how much fat is stored in the body. This messenger is sent to the brain around midnight when we are sleeping allowing the brain to assess total energy balance in the body.

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Brain Gut 5: Paradigm Drifts Paradigm Shifts–Epi-Paleo

Geeks: The implications of Brain Gut 4 mean that to develop a brain seafood is required part of the program to maintain it. Nutrients and many other environmental factors have also been found to influence epigenetic programing of our DNA either directly or indirectly via metabolic sensors. Peroxisomal proliferator-activated receptors (PPAR’s), the vitamin D receptors, and the retinoid X receptors (RXR), and the retinoic acid receptors (RAR) are all examples of the nuclear receptors that interact with the brain cell membranes to control inflammation and metabolism all over our bodies. It turns out that PPAR’s are the receptors that are at the crossroads of where inflammation and metabolism actually cross. These are specialized lipid sensors that pay attention to our balance of omega 6 and 3 levels. 3% of the human genome is directly or indirectly controlled by the endocrine functions of the Vitamin D system. This shows you how environmental signals are intertwined into the expression of DNA in humans. The Epi-Paleo Rx controls inflammation at a hormonal level in the brain better than the more famous paleo diet.

Non Geeks: What we eat is really damn important when you have 3 lbs of lipid in your head called a brain. If you eat outside our design you get sick.

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Brain Gut 2: Viral Marketing

READERS SUMMARY: 1. To discover the unknown we must use the known to guide our thoughts to see the future. 2.  How should we think about evolution and health now?  Counterintuitive is an axiomatic cognitive ability  required for neurosurgical residency training and that is why I chose to tackle this problem in this fashion. 3.  If we want to explore the mystery of our clade we need to go back to the things that separate us from them that we know to be true today.  The knowns are that our EQ (encephalization quotient) exploded rapidly.  WHY? 4.  Is our past really our new prologue?   Todays blog is to show you how Factor X was made actionable in bring man from ape.  Most of you know, I believe it was due to a faster epigenetic plan that altered the mammalian body plan.  What most do not know it was the result of viral marketing.  This is not the viral marketing of today’s social media platform.  This is where viral marketing was truly invented.  First created in our oceans,  and eventually incorporated into the DNA of life.  Do you think this hyperbole?  One drop of sea water has a million bacteria […]

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E=MC2: MAKING FACTOR X ACTIONABLE

READERS SUMMARY: 1. How does the fossil record prove that epigenetics is the most dominant factor in biology today? 2. How does this lack of insight create a huge mismatch for patients trying to get to Optimal? 3. Does epigenetics change they way we think? 4. Does the way we think alter our biology and can it alter the medicine we practice? 5. How do we make this actionable for patients? In the famous equation E=mc2 we all know that the speed of light is the most important variable in the power of the equation. This has become the logical syntax of science the last 100 years. This is why a nuclear weapon has the energy it does from two small blocks of metals that get exploded into us. The equation is now being challenged by new wave scientists. In fact, one of them spoke at the TEDx Nashville event I participated in and I found his talk fascination on many levels. I love people who challenge scientific dogma. Might there be a similar ‘weighted or squared factor’ in biology that does the same thing to a biologic system? Might that one factor have the same magnitude on modern man? […]

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Cold Thermogenesis 5: Biologic magnetism

My first encounter with thermoplasticity in human biology

I first became aware of this seeming paradox as a neurosurgical resident in my first year of training. We were doing a real “gnarly” brain surgery case. It was a young mother who had a massive basilar tip aneurysm. Back in the mid 90’s before endovascular coiling procedures we use today, this was the most risky operation that existed in all of medicine. I spent a month prepping for this case. We had to enlist the cardiovascular surgeons to come in and surgically open the patients chest wide open to stop her heart on purpose temporarily and place her on complete cardiopulmonary bypass to stop all the blood flow to her brain. We had less than 20 minutes to then place a clip across the aneurysm to save her life. To complete this herculean surgical task, we had to fill her entire chest cavity with ice to preserve her heart muscle and cool her core temperature so that we could have 20 minutes to complete the brain surgery. Simultaneously, we would open her skull and split the Sylvian fissure in the brain and approach her basilar artery in the geographic center of her head and attempt to put a clip on it without disturbing any of her surrounding anatomy. The best mental image I can give you for this is the ultimate game of “Operation” you used to play as a kid. You must avoid hitting the sides or the nose lights up!!!! One problem in this case, in this game there was live bullets. This maneuver was deadly if not performed correctly the first time. This is one of the most delicate surgeries one can do on a human. Moreover, even if we were successful with the clip obliteration of the aneurysm, we had to restart her frozen heart, get her off cardio pulmonary bypass without an air embolus and awake. In this case everything went well until the last part and this taught me a lesson I would never forget. She died after the operation was a complete success. Her head was already closed up surgically and dressed, the intraoperative angiogram looked awesome, and we restarted her heart and got her off cardio pulmonary bypass without any evidence of a stroke and then she died suddenly.

She received two units of cooled banked blood because our surgical team felt she lost some ability to carry oxygen in her blood because several of the monitors showed she had a low oxygen carrying capacity of her hemoglobin. This concerned us because we were worried about her risk of having a stroke because of low oxygenation due to her loss of blood flow for 20 minutes when she was on full bypass.

So we did what any surgeon would do. We gave her blood to restore her oxygen carrying capacity and the oxygen monitors showed her oxygenation had totally returned to normal. We were all happy until I noticed her pupils were fixed and dilated when I was putting on her dressings. She also had blue fingers. And then all of a sudden she got a fatal heart rhythm, and she died right there in my arms. I was devastated. I will never forget talking to her family later that day.

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PRIMAL CPC 1: TOURETTE SYNDROME MEETS EVOLUTIONARY MEDICINE

READERS SUMMARY: 1. WHAT IS TOURETTE’S SYNDROME? 2. HOW MIGHT IT BE LINKED TO A LEAKY GUT, GRAINS, AND TIE TO OTHER DISEASE’S WE KNOW NADA ABOUT? 3. HOW DOES OUR HARDWIRING GIVE US NEW INSIGHTS? 4. HOW MIGHT NEUROSURGERY HELP CHRIS JOHNSON? 5. HOW MIGHT SOME PIONEERING DENTISTS TIED A NICE BOW ON THERAPY FOR CHRONIC TS PATIENTS?   Tourette’s syndrome (TS) is defined as an inherited neurological disorder that is a chronic idiopathic syndrome that neurosurgeons consider in the family of movement disorders. Today’s blog is called a CPC. That is known as a clinico-pathologic conference for my readers. Every so often I am going to post about a disease process and how evolutionary medicine may look at something that modern medicine is vexed by. We neurosurgeons generally do not treat these patients but neurologist however do.  In my town of Nashville,  we have a very famous running back, Chris Johnson,  who is a superstar that has a variant of this condition.  The disease is characterized by the presence of multiple muscle tics and occasionally vocal tics that have their beginning before adulthood.  It usually occurs with an onset in childhood between ages 5-8.  A diagnosis of TS was almost three times as likely for boys as girls, […]

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WHY YOU NEED TO THINK FOR YOURSELF

READERS SUMMARY: 1. Why you should be disgusted with our policy on diabetes. 2. How is one to survive the situation. 3. What can you do to avoid this situation and to thrive?   I read an article this morning in my local Sunday paper that stopped me dead in my tracks and caused me to write this. Majid Ezzati is the chairman of global health at Imperial College of London and his study was just published in The Lancet just last night. The study was based using data from 150 published national studies that followed adults over 25 years in 199 countries. The study used modeling to estimate the numbers for 92 other countries. I am not a fan of this type of science but I have to say, I believe they under-called the problem in a big way. The modeling did not take into account the three youngest generations world wide. More importantly, It failed to include the youngest three generations obesity crisis in the biggest problem country. That country is the USA.   When I was on Jimmy Moore’s podcast this May, I estimated that the numbers in the USA for type two diabetes were north of […]

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