Quantum Biology 9: Photosynthesis

Life is energy. All life is tied to our sun. The sun powers everything with the photoelectric effect. Today, you are going to see how this quantum effect makes life dance.

To synthesize simple carbohydrates from sunlight requires 30 proteins to work together in a cell membrane. Research into the mechanism of photosynthesis centers on the understanding the structure of the photosynthetic components and the molecular processes that use radiant EMF energy to drive carbohydrate synthesis. The research involves several disciplines, including physics, biophysics, chemistry, structural biology, biochemistry, molecular biology and physiology, and serves as an outstanding example of the success of multidisciplinary research. This process should give us a clue that systems thinking about problems could solve many modern mysteries.

In our universe, and in all life forms, energy’s primordial state is not rest. Energy does not like to sit around like a couch potato. If you do sit around often like this, this is a quantum sign that you are losing energy in the forms of electrons, photons, phonons, and protons to you own environment. Today’s blog is on the quantum biology of energy dynamics. In the universe, as there is in things living energy is always present. The key factor, however, for life is the amount of energy in its therapeutic dose. A body without energy is called a cadaver. A body with a lot of energy is like a trendy party animal. Energy propels our planes, trains and automobiles to move, and it keeps us warm, grows our food, and helps us see the world we live in.

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EMF 4: Why Might You Need Carbs for Performance?

Today EMF-4 is going to hit a very controversial topic. Why do the younger performers perceive they need carbs for performance? For years, I have said loudly, I don’t believe it is true. Over the last 7 years I have begun to understand why their belief exists now. When you suffer from a disrupted circadian clock you perceive you do need carbs.

It has been shown recently that artificial EMF’s make our blood brain barrier and gut more permeable to carbohydrates. The micropulsations of EMF control biocycles, including the timing of mitotic rhythm and the entire cell cycle. Any major change in their frequency would be catastrophic for cells. In fact, today most of the paleo-sphere is unaware that experiments already have been done that have shown that vibrational rates near normal and slightly above the Schumann resonance, from 30-100 Hz, cause dramatic changes in the cell cycle timing.

It turns out, the most powerful shaper of our development may turn out to be the subtlest force, that is completely invisible to us and perturbs the manner in which we handle macronutrients and recycle ATP.

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EMF 3: The Origin of Life

“If you are out to describe the truth, leave elegance to the tailor.” —Einstein

The implications of the last blog, EMF 2 are massive for biology. Those two space experiments show us that time contractions when we lose the sensation of magnetism, and it dilates when we increase it. This implies we can die faster or reverse disease if we understand how it affects us. With this knowledge I knew I could help reverse many neolithic diseases. But it dawned on me on the plane ride home it also might explain how life really began in our oceans.

The irony here, is two days before, I was standing in Rome in the Sistine Chapel showing my son the center panel of Michelangelo’s masterpiece ceiling. It was then I realized I might want to know God’s thoughts. I want to know God’s thoughts in a biologic way……..and the path to that way used an alphabet called evolution.

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EMF 2: Einstein, Meet Leptin

“You’ve got to work at living… when 99% of the globe works at dying daily; Denial of the truth will lead you into blind alleys. Let go of your paradigm, accept what nature designed, and embrace your ultimate potential” -Gretchen Bronson (starfish)
Why is the clock the most important part of the story of life?

Have you ever had a dream that seems so large in scope, it just seems like it just possibly cannot come to fruition? I have for the last 7 years. Today, I am going to share it with you.

It is time. I believe all dreams come true, if we have the courage to pursue them. It is always easier to make a dollar off a dream, but it is a lot tougher to make a difference with one. I think EMF-2, is going to do just that for everyone.

I told you all last March, on Sean Croxton’s underground internet radio show, and at Paleo FX 2012, that environmental mismatches all cause inflammation. Many of you found it a bold and interesting statement, but I never told you WHY. The reason I did not, was because I did not feel you were ready to understand my perspective, yet. Today that changes. When you do not understand someone’s perspective often times what they say sometimes sounds a bit ‘bizarre’ to you. The reason it does is because you have no frame of reference for understanding, primarily because you were never taught that space/time, might be the most critical factor in understanding trans-generational epigenetic biology today. That is going to change today as well.

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BRAIN GUT 17: THE POWER SQUAT

Today we are going to talk a bit about your “out door” as part of the brain gut series continues.  Today I am going to show you how spinal biomechanics and defecation are intimately related to good or poor physiologic function and may result in illness.  The human spine has 5 lumbar verterae and one block of bone distal to it called the sacrum.  The sacrum forms the back bony wall of the pelvis. 

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Brain Gut 9: What Really Killed Michael Jackson

Today, we are going to dive into the gut flora story a bit deeper than we did in our first gut flora post to help you understand how a a change in gut flora might lead to changes in your health by altering your hormone panel. Obesity is an inflammatory brain condition. Where does the infection come from? The gut flora actually is what causes humans to become fat. It has to due with shear numbers and the species of bacteria in our gut. There is a particular flora that produces adiposity and obesity in humans. These bacteria make something called FIAF (Fasting induced adipose factor) that control this process. This factor blocks lipoprotein lipase (LPL) in fat cells. LPL allows us to convert dietary Free Fatty Acids carried in lipoproteins into neutral fats that are stored in adipocytes.

Non Geeks: Our gut bacteria makes humans fat.

Geek Alert: The FIAF is made by our liver, muscles, and our small bowel wall when food sources are in short supply. This is the signal to stop storing fat in our fat cells when food is scarce. What is not well appreciated by many is that the FIAF in our intestinal wall is controlled 100% by our gut flora. When we have a simplified gut flora it favors fat cell creation. When our gut flora is complex and healthy, it has 100 trillion cells with 250 species. We tend not to make fat in this instance either! Moreover, when the bacteria are active metabolically due to the presence of simple sugars, production of FIAF ceases, and fat creation is signaled. This implies that our gut flora is directly tied to fat creation in humans. The gut flora’s action is directly signaled to the brain via the afferent nerve fibers in the vagus nerve. In those newly created fat cells, a protein called leptin is also produced, and acts as a score keeper for the brain of how much fat is stored in the body. This messenger is sent to the brain around midnight when we are sleeping allowing the brain to assess total energy balance in the body.

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BRAIN GUT 7: INTRO TO YOUR GUT MICROBIOME

Many of you know I believe obesity if an inflammatory disease of the brain. Where this disease begins may surprise some of you. It begins in our gut flora. How does this happen? Read this link! Sub optimal bacteria which contain bacterial toxins called lipopolysaccharides (LPS) which are found in bacterial cell membranes. As gut LPS rises, it has been shown to cause a rise in serum leptin levels. Once leptin levels are raised high enough it stimulates SOCS 3 signaling in the hypothalamus to cause LR.

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Brain Gut 6: Epi-Paleo Rx

This blog followed a very popular July 2012 Webinar that I put on for my members a few days ago. The webinar was over two hours long and had a lot of Q & A done after it as well. I promised my members I would get a quick blog post up for them on some of the core materials we covered. Today’s blog is delivering on that promise.

How to consider eating the Epi-Paleo Rx: Always Respect circadian cycles and eat according to seasonality, Lots of good quality proteins (see below), Lots of good quality fats (grass-fed/pastured animal fats – lard, tallow), Liberal uses of seafood broths and bone broth made from ocean and grass-fed animals (to heal the gut), and fermented vegetables and/or probiotics (to repopulate the gut with an Optimal Human flora)

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Brain Gut 2: Viral Marketing

READERS SUMMARY: 1. To discover the unknown we must use the known to guide our thoughts to see the future. 2.  How should we think about evolution and health now?  Counterintuitive is an axiomatic cognitive ability  required for neurosurgical residency training and that is why I chose to tackle this problem in this fashion. 3.  If we want to explore the mystery of our clade we need to go back to the things that separate us from them that we know to be true today.  The knowns are that our EQ (encephalization quotient) exploded rapidly.  WHY? 4.  Is our past really our new prologue?   Todays blog is to show you how Factor X was made actionable in bring man from ape.  Most of you know, I believe it was due to a faster epigenetic plan that altered the mammalian body plan.  What most do not know it was the result of viral marketing.  This is not the viral marketing of today’s social media platform.  This is where viral marketing was truly invented.  First created in our oceans,  and eventually incorporated into the DNA of life.  Do you think this hyperbole?  One drop of sea water has a million bacteria […]

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Cold Thermogenesis 11: Paleo FX To Practice

Today, I want to introduce you to someone who is a true ‘Paleo leader’ by stepping up to the the challenge I put to our community at PaleoFx conference recently held in Austin, Tx. Kevin Cottrell is one of the co founders of Paleo Fx. The leaders of Paleo fx have to be commended because the conference they were able to put on in 150 days of prep time was nothing short of remarkable.

The conference exceeded all my expectations and the reviews of many attendees have been stellar. The future of this community is tied to clinical application of what the science continues to show in the literature. For assimilation of the Ancestral Lifestyle to become mainstream we need to have more clinical conferences like Paleo fx, and we need to take them globally.

Today, I am breaking new ground and presenting to you my first guest blog written by Mr. Kevin Cottrell, who has agreed to share his personal story and personal medical history with all of you so that he may help you in some way. I think what he has agreed to do here is the most noble and worthy things to do to help our community and mankind. I am indebted to him for this chance to publish his story for you to consider.

The following post is written by Kevin, in his words, to share with you and yours, to help open your eyes and challenge your “own dogma and current intuition’ to help you reach for optimal health.

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Cold Thermogenesis 8

Radical Theory #1: If our brains can rewire, then Einstein’s theories predict our biochemistry should be able to as well. My Leptin Rx and the modern cochlea implant definitively prove this in modern humans.

Radical Theory #2: Considering that 90% of the earth’s current biome lives in extreme conditions on our own planet today still, we might need to consider that what we think is “our normal environment” is not so normal for most of life on our planet or our evolutionary history. Life on Earth evolved in an environment much like we see on Titan today; in a deep ocean frozen solid at its surface with the capability of life buried deep with in it. The only escape was due to ejectants of water vapor from super heated water from underwater volcanoes. All these things are present today on Earth’s crust too. There is one major difference now between the two. We are a lot warmer today than when life began. There are others, but when one looks at Titan we see a frozen giant moon with a monstrous ocean beneath it.

All life on our planet came from the oceans first. We know this to be true as well. And because of this, studying extremophile forms of life here on earth today might explain the complexities of how biochemistry allows for life to exist at all in a thermoplastic environment.

What the bio-astrophysics found on Titan with the Cassini Solstice mission, may be a huge clue that life first adapted to extreme environments and then was naturally selected and adapted to a cyclic warming trend on our planet’s crust over time.

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Cold Thermogenesis 6: The Ancient Pathway

The best way to describe this pathway to the lay public is to explain this is how evolution allows for ideal form to meet function in a tough environment. This environment is likely the primordial environment for life on our planet. This makes astrophysicists excited, because life might also be evolving in places like Titan. After all 5 extinction events on this planet geologist have told us they were followed by an extended cold climate. In cold mammals live longer. You will find out more about why this happens in Energy and Epigenetics 4 and 5 blog posts.

The pathway uses very little energy from ATP and gives a whole lot to the organism who uses it. Fat burning is required and it is tied to a biochemical pathway that paleo forgot to speak about. But it requires cold temperature to be present and used commonly. In the pathway, the less effort you give, the faster and more powerful you will be when this pathway is active. People who live in this pathway can run a marathon with no training. They can lift unreal amounts of weight with little training. Their reserve and recovery are just incredible. You have to see it to believe it. Many will say cold thermogenesis a hormetic process, when in reality it is created using a coherent energy source due to something called the Hall effect. When we have had extinction events on Earth before, the events usually affect the evaporation of water in some fashion from the surface of lakes and oceans. It also affects the transpiration from the forest trees, plants, and flowers and this change cools the air. You must understand how climatology works here; liquid water needs to absorb a lot of latent heat to in order to evaporate, so it sucks energy from the atmosphere to make this energy transfer. This loss of energy from the atmosphere directly cools the planet and this preserves the charge on life’s inner mitochondrial membrane and in the nanotubes present in our cells that contain water. This is how life lives long in the cold.

Those people don’t realize this because they do not live in this pathway for the majority of their life, and few studies have been done to say otherwise. The link above is recently added to this blog post. It seems science is now proving me correct in my theories of extinction events.

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Cold Thermogenesis 5: Biologic magnetism

My first encounter with thermoplasticity in human biology

I first became aware of this seeming paradox as a neurosurgical resident in my first year of training. We were doing a real “gnarly” brain surgery case. It was a young mother who had a massive basilar tip aneurysm. Back in the mid 90’s before endovascular coiling procedures we use today, this was the most risky operation that existed in all of medicine. I spent a month prepping for this case. We had to enlist the cardiovascular surgeons to come in and surgically open the patients chest wide open to stop her heart on purpose temporarily and place her on complete cardiopulmonary bypass to stop all the blood flow to her brain. We had less than 20 minutes to then place a clip across the aneurysm to save her life. To complete this herculean surgical task, we had to fill her entire chest cavity with ice to preserve her heart muscle and cool her core temperature so that we could have 20 minutes to complete the brain surgery. Simultaneously, we would open her skull and split the Sylvian fissure in the brain and approach her basilar artery in the geographic center of her head and attempt to put a clip on it without disturbing any of her surrounding anatomy. The best mental image I can give you for this is the ultimate game of “Operation” you used to play as a kid. You must avoid hitting the sides or the nose lights up!!!! One problem in this case, in this game there was live bullets. This maneuver was deadly if not performed correctly the first time. This is one of the most delicate surgeries one can do on a human. Moreover, even if we were successful with the clip obliteration of the aneurysm, we had to restart her frozen heart, get her off cardio pulmonary bypass without an air embolus and awake. In this case everything went well until the last part and this taught me a lesson I would never forget. She died after the operation was a complete success. Her head was already closed up surgically and dressed, the intraoperative angiogram looked awesome, and we restarted her heart and got her off cardio pulmonary bypass without any evidence of a stroke and then she died suddenly.

She received two units of cooled banked blood because our surgical team felt she lost some ability to carry oxygen in her blood because several of the monitors showed she had a low oxygen carrying capacity of her hemoglobin. This concerned us because we were worried about her risk of having a stroke because of low oxygenation due to her loss of blood flow for 20 minutes when she was on full bypass.

So we did what any surgeon would do. We gave her blood to restore her oxygen carrying capacity and the oxygen monitors showed her oxygenation had totally returned to normal. We were all happy until I noticed her pupils were fixed and dilated when I was putting on her dressings. She also had blue fingers. And then all of a sudden she got a fatal heart rhythm, and she died right there in my arms. I was devastated. I will never forget talking to her family later that day.

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Cold Thermogenesis 3

Evolutionary strategy is based upon finding an environmental niche and exploiting it. Evolution is based upon change and the natural adaptations to it. Today, we are going to explore how some environmental triggers might open a “biochemical trap door.”
Why is circadian biology critical?

For evolution to work, a cell first must adapt to its environment. So the first thing any living cell would see in an earth day is a period of day and night. It also has to find food to make energy (ATP). In addition, it has to control its own cellular division. The epic battle for the cell is the circadian cycle has to “yoke” the metabolic cycle to its growth cycle. Most people know that the suprachiasmatic nucleus (SCN), is the circadian pacemaker that monitors this dance between darkness and light and the seasonal cold and hot temperatures in our environment. Evolution apparently agreed with this assessment, because we now know it to be true.

What most people do not know is how leptin plays a massive role in regulating it. Research has revealed that leptin can induce expression of a neuropeptide gene called vasoactive intestinal peptide (VIP) through the VIP cytokine response element. VIP actually is what sets the circadian pacemaker to light. Leptin yokes metabolism and sleep to the light and dark cycle. When temperature becomes the dominant environmental trigger and not light cycles, leptin induces endothelial nitric oxide synthetase (eNOS), that shuts down the photic effects of VIP on the SCN. This means that leptin forces the SCN not to be able to use light any longer to yoke circadian cycles! Once temperature begins to yoke the circadian rhythms, some very special things happen to our biochemistry that normally does not occur in other environments. These are ancient epigenetic programs that are hardwired into the DNA of every descendant of a eutherian mammal. We are descended from these animals.

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PRIMAL CPC 1: TOURETTE SYNDROME MEETS EVOLUTIONARY MEDICINE

READERS SUMMARY: 1. WHAT IS TOURETTE’S SYNDROME? 2. HOW MIGHT IT BE LINKED TO A LEAKY GUT, GRAINS, AND TIE TO OTHER DISEASE’S WE KNOW NADA ABOUT? 3. HOW DOES OUR HARDWIRING GIVE US NEW INSIGHTS? 4. HOW MIGHT NEUROSURGERY HELP CHRIS JOHNSON? 5. HOW MIGHT SOME PIONEERING DENTISTS TIED A NICE BOW ON THERAPY FOR CHRONIC TS PATIENTS?   Tourette’s syndrome (TS) is defined as an inherited neurological disorder that is a chronic idiopathic syndrome that neurosurgeons consider in the family of movement disorders. Today’s blog is called a CPC. That is known as a clinico-pathologic conference for my readers. Every so often I am going to post about a disease process and how evolutionary medicine may look at something that modern medicine is vexed by. We neurosurgeons generally do not treat these patients but neurologist however do.  In my town of Nashville,  we have a very famous running back, Chris Johnson,  who is a superstar that has a variant of this condition.  The disease is characterized by the presence of multiple muscle tics and occasionally vocal tics that have their beginning before adulthood.  It usually occurs with an onset in childhood between ages 5-8.  A diagnosis of TS was almost three times as likely for boys as girls, […]

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Hey Lyme Disease, Meet Leptin!

I do not believe there is a more misunderstood disease by conventional medicine than Lyme disease and Fibromyalgia. Many healthcare providers do not even think FM exists to the determent of millions of people. It is estimated that ten million people suffer from these diseases today. 75% of them are women. The reason for that is because leptin is involved, and as you all know it is a sexually dimorphic hormone. These are diseases that affect the fat cells in all parts of our body. They also cause issues with adiponectin, which is also sexually dimorphic. Many women will be glad to know that fact. Understanding Lyme disease actually helps you understand FM very well.

Both diseases cause abnormal activation of an immune mediated pathway that takes over cytokine production in the fat cells that line our GI tracts, respiratory tracts, sinuses, and many other organs. Most know that Lyme is most commonly associated with a tick bite, and the host gets infected with spirochete bacteria. What most do not know, is that this tick liberates a neurotoxin that causes most of its symptoms. This neurotoxin activation is common to many diseases just like Lyme disease. FM, Chronic Fatigue Syndrome, Sick building Syndrome, and mold exposure are just a few. All these diseases activate the same pathway, and this is why they have features that are quite similar clinical findings. Making these connections clinically helped me tie this all together. Since I came to a deep understanding of how important leptin is to our body several years ago, it made complete sense to me to think all these diseases might have a leptin link because of the constellation of symptoms were all tied to specific cytokine activation. This is precisely how leptin resistance develops too. This is how a change of perspective might help a physician see a problem in a new way. It is precisely how Evolutionary medicine prism has allowed me to come to bio-hack just about any disease we face as a species now.

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How Does The Leptin Rx Work?

Many people have contacted me about “why” the leptin Rx works and “how” does it work. Many people in the blogosphere have made some claims that much of what is in the leptin Rx is a rehash of the work found in some diet books. Well, today’s post is being done to show you the science underneath my recommendations were formulated and made. None of the underlying science I will mention to you about neuroplasticity will be found in any diet book mentioned in any blog post that I know of. Most of you know I am a neurosurgeon, and as such, I was dramatically influenced by two world famous neurosurgeons named Wilder Penfield and David Kline. Dr. Penfield was the first neurosurgeon to use electrodes on the brain to map it prior to surgeries to avoid neurologic damage during tumor removal. Dr. Kline was and still is the pre eminent world expert in peripheral nerve surgery. I happened to train with Dr. Kline in New Orleans, and got turned on to his work, Dr. Penfield’s work and the work of Dr. Merzenich in the early 1990’s before leptin was even discovered. Dr. Michael Merzenich work on sectioning the median nerve in the hand and seeing how the brain remapped its sensory territory in the cortex via micro-electrodes was brought to my attention by Dr. Kline while I was a resident.

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What Are The Optimizing Labs?

When you finally decide to take total control of you life and optimize yourself I always suggest testing. Many of you have bombarded my email and my twitter account for a blog to a list of those labs. Well, today’s post is for you. I was resistant to do this because I felt having the list of labs is a waste of time if you don’t have a physician who can decipher what they all mean for you. 7 years ago, I could not tell you what this group of labs meant at all to your optimal health. I learned it by reading and going to classes to optimize myself. After much reflection I have decided to give you what you asked for. I am fortunate because many of the PCP’s I work with understand these tests well. I may also update it as I think it needs to be updated over time.

The first set of labs are what I call the core lab set for optimization. There are other panels I add to the core lab based upon the history, physical, and the food logs I will have patients give me. This blog is meant to be a resource for you to refer back to when the need arises. Discuss these with your doctor but don’t assume they will run out to order them because they may not know what all these tests will tell them. That part takes some time. I recommend starting the dialogue with your doctor to assess their willingness to help you. Most of my PCP doctors are awesome “helpers” to their patients with these issues. This requires a lot of work on the doctors part and the patients part. Do not be surprised if this is not covered by insurance. The time required to optimize someone is unreal. I know how long I spent optimizing myself 6 years ago. It was a tedious process but I was not going to give up because I believed my life depended upon it. For most people, 2-3 years you can expect the changes you want. If you are really in tough shape it may take longer but that should not deter you. I love patients who bring big challenges. They are the most appreciative patients I have had in the last 5 years. We can never settle for a C or D when an A is possible.

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Where Autoimmunity, Cancer and Disease Collide

READERS SUMMARY: 1. What ties Levee 5, 6, and 16 all together in the QUILT? 2. Why is Vitamin D and Selenium the key to the gut? 3. How does Vitamin K play a role? 4. Why is autoimmune disease, cancer and neolithic disease more common today than ever before? 5. Is there another environmental toxin that we can not perceive that is behind this? I believe heart disease and inflammatory bowel diseases are pre-cancerous states. I also believe autoimmunity is a precancerous state. I believe autoimmunity and cancer are just steps apart. I also believe we will soon find that these diseases are linked to an altered environment and circadian signaling.  Epidemiological studies link all these disease to inflammation generation. The pathway in humans tied to inflammation is the NRF2 pathway.  This pathway underpins the Hormone 101 and 102 blog posts.  Most people and doctors already know there are links to inflammation but they are not sure how they link to circadian mismatches. But what is less talked about is how this all fits biologically. Today we are going to begin to tackle this. I think two critical co-variables need to be looked at in detail and are found […]

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Could It Be the Gut?: An Introduction to the Brain-Gut Axis

READERS SUMMARY: 1. What is the brain gut axis? 2. What diseases likely are tied to its breakdown? 3. Why might medical training force us to miss the importance of this axis? 4. How did I discover the brain gut axis in my own clinical practice? 5. Did evolution dictate where the initial battle of immunity should lie? When many doctors hear me talk about the brain gut axis I get lots of funny looks. See, this is an axis that we do not formally learn about in anatomy in medical school. We learn about systems in anatomy that are organized as tissues within organs. Physiology is where organ integration and its function is taught. Guess what? We did not learn about the brain gut axis there either. In fact, when I was in medical school and residency, I never once heard or attended a lecture of this axis that I believe is the fifth most important levee in my cellular theory of health! I personally believe that medicine is going to revolutionized by the science that is uncovered in this axis over the next few decades. I believe the diseases that currently have no cure or known cause will […]

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