Energy and Epigenetics 7: The Epigenetic Toolbox

The human genome is the first draft of what we might be, but our life experience within the environment we choose to exist is where the final draft of our book is written. An architect far smarter than us has given us that epigenetic toolbox, and we now have the ability to use it by altering our behaviors to change our lives and reverse diseases.

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April Webinar: PPP–The Fat Burning Pathway (The BIG KAHUNA!!!)

April Webinar: PPP–The Fat Burning Pathway  (The BIG KAHUNA!!!) In his webinar, Dr. Kruse is going to explore how hormones, perimenopause, menopause and andropause are all tied to the quantum electrodynamic (QED) theory.   You will be particularly interested in this webinar if: You’ve been on the road to optimal, and you’ve experienced “stalls” You’re a “lab hacker” – meaning, you have your labs done regularly, and you want to better-understand what you’re seeing     in your own labs and how to continue optimizing your health You or someone you love has ever suffered from infertility If you feel like you’re doing “everything right,” but you’re not losing weight or sleeping as well as you think you can Your hormone panel isn’t budging, even with taking bioidentical hormones You’re a woman.  Or a man.  (I think that about covers it.) Dr. Kruse is going to really drill in to help us understand how to get into the PPP, including how to determine your total body water and total body water deficit to see how far out of the pathway you are (if you’ve been following along this year, you know we’ve focused particularly on water and semi-conduction and it’s […]

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February Webinar: The Sleep Rx!

The February Webinar: The Sleep Rx One of the most common disease-promoting conditions we face in western culture is the inability to sleep well.  Many, many people report sleep problems that include: Not being able to fall asleep Excessive daytime tiredness Waking frequently to use the restroom Awakening in the morning, feeling exhausted Bad cognitive function – not thinking well or clearly or deeply; fuzzy brain Personality changes – “You don’t seem your normal self.” By the time we’re having trouble sleeping, the train has already gone off the rails–a sign that our circadian biology is really jacked.  Many people have accepted poor sleep as a reality of life, or don’t realize how their poor sleep is a major contributing to things like: Schizophrenia Type 2 Diabetes Psoriasis Eczema Acne Adrenal Fatigue Restless Leg Syndrome Diabetic Neuropathy Migraine Headaches Perimenopause Anger issues and more There are a few main reasons our sleep begins to deteriorate in the first place, and during this webinar, we are going to explore how artificial light; non-thermal, pulsed EMF; eating carbs in the winter; concussions; traumatic head / brain injury; and surgery or radiation to the head (including things like CT scans) all can create circadian chaos that interferes with […]

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EMF 2: Einstein, Meet Leptin

“You’ve got to work at living… when 99% of the globe works at dying daily; Denial of the truth will lead you into blind alleys. Let go of your paradigm, accept what nature designed, and embrace your ultimate potential” -Gretchen Bronson (starfish)
Why is the clock the most important part of the story of life?

Have you ever had a dream that seems so large in scope, it just seems like it just possibly cannot come to fruition? I have for the last 7 years. Today, I am going to share it with you.

It is time. I believe all dreams come true, if we have the courage to pursue them. It is always easier to make a dollar off a dream, but it is a lot tougher to make a difference with one. I think EMF-2, is going to do just that for everyone.

I told you all last March, on Sean Croxton’s underground internet radio show, and at Paleo FX 2012, that environmental mismatches all cause inflammation. Many of you found it a bold and interesting statement, but I never told you WHY. The reason I did not, was because I did not feel you were ready to understand my perspective, yet. Today that changes. When you do not understand someone’s perspective often times what they say sometimes sounds a bit ‘bizarre’ to you. The reason it does is because you have no frame of reference for understanding, primarily because you were never taught that space/time, might be the most critical factor in understanding trans-generational epigenetic biology today. That is going to change today as well.

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BRAIN GUT 11: IS TECHNOLOGY AN ACHILLES HEEL?

READERS SUMMARY:   1. A QUESTION DURING AN EDUCATIONAL CONSULT STIMULATES A DISCUSSION 2.  HOW DOES ARTIFICIAL LIGHT DESTROY THE SIGNALING OF THE CORTISOL/DHEA/MELATONIN AXIS? 3. HOW DOES ARTIFICIAL LIGHT AFFECT  THE GUT FLORA? 4.  CAN ARTIFICIAL LIGHT AFFECT HUMAN BIOLOGY DIRECTLY? 5.  IS BODY COMPOSITION TIED TO ARTIFICAL LIGHT AND IMPAIRED SLEEP CYCLES?     Question asked to me during an educational consult: I still don’t understand the significance of the prolactin surge especially in older people like me. Since I am post menopausal, what happens if I eat carbohydrates within 4 hours of going to sleep? What does it have to do with leptin resistance? I am neither a science person, so is there any way to explain it in less technical terms?     BEFORE WE BEGIN TAKE A LOOK HERE AND TELL ME IF YOU THINK EVOLUTION HAS A PLAN FOR THIS?   I hope everyone realizes that artificial light has only been around on our planet since 1924.   Just so we are clear. Chronic artificial blue light is equivalent to chronic excessive carbohydrates because both contain excessive photoelectric energies.  This alters mitochondrial functioning after a period of time because our mitochondria evolved expecting a […]

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BRAIN GUT 10: The Other Trip through the Rabbit Hole:

My name is Danielle Thatcher and here is my story of the rabbit hole I fell into with MJ when we met Dr. Kruse on his vacation:   When I first sat down to write about my experience with meeting Dr. K, I had the highest of hopes of writing something that would and could inspire many. But when I did sit down to write…. I had nothing.  Literally, nothing. My mind was blank.  I take that back, I have the notes that Dr. Kruse so willingly wrote down for me and the notes that MJ took as well.  But I spent an entire day with this great man, and my mind is blank. Pretty scary for a 45 year old woman!   Before I forget, this is only one of the supplements Dr. Kruse asked me to consider with my doctor for me. Pregnenolone.   If you have insufficient levels of pregnenolone, you can have memory loss, sleep disorders, depression, fatigue, symptoms that mimic Alzheimer’s and other debilitating conditions. I am experiencing many of these symptoms, so I am sure to take my supplements and just waiting for everything to “click” and this machine to start functioning again properly.   The good news […]

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Brain Gut 8: Their Trip Down the Rabbit Hole

READERS SUMMARY: 1.  What is a day in the life of a vacationing doctor like? 2. Accept that your epigenome is a loaded gun, and your lifestyle is the trigger. Your lifestyle can’t change you. It reveals who you really are. 3.  Is there an important difference between giving up on somethings and letting go to get to Optimal? 4.  You are not your brain. Most of your thoughts and beliefs were given to you by society. 5. When we don’t know who we are, we are prone to be who somebody else wants us to be.  We can change that.     Today we have a guest blog post from MJ Friedman, one of two of our community members who decided to come down south and get a first hand view of what Optimal is really all about.  The other person is Danielle Thatcher.  The following blog are MJ’s words about her 24 hours with me while I was on vacation.  I needed a break and decided to take time off and not go to Boston to be at AHS 2012.  It turns out work seems to follow me no matter where I go now.   Here is Mrs. Friedman’s day……….. […]

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Hormone CPC #1: DHEA

This blog post was created for my members who just heard my webinar on bioidentical and synthetic hormone replacement. It is specifically designed to further our discussions in that talk.

DHEA has been an enigma to the public and to most physicians. I never once heard about this hormone in four years of medical school, seven years of residency or in any endocrinology lecture from my training. The general public did not learn about DHEA until 1996, when its benefits were mentioned in the media and several popular books that showed up on daytime TV shows. Most in mainstream medicine continued to ignore the science these books contained because they were not found in the usual ways via journals and continuing education classes. You actually had to be on the lookout for this information. With a busy medical practice, this is no easy task. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book called DHEA and Aging. That book provided scientific validation for the many life-extending effects of DHEA.

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Cold Thermogenesis 13: The FAQ’s

The readers of my forum asked for a FAQ’s on CT and I decided it would be a good idea to make a short blog about this. They picked their top 25 questions and I decided to answer them for this blog. If you have any others, just ask in the comments section. I answer them all when I have time.

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Cold Thermogenesis 7

CT-7 is about how we are shaped by our environment by the evolutionary erosion of time that our ancestors faced. All life on this planet is shaped by two major variables in our environment: the sun and the seasonal changes. No matter the place present on earth, there are always alterations in these two factors that are cyclic, and always accounted for by all living organisms at some fashion. In some mammals, like man, it is accounted for centrally in the brain and peripherally in our organ ultradian clocks.

This is why we have different patterns of aging in certain organs. From an evolutionary perspective, this makes a tremendous amount of sense because life is using the “knowns” of its environment to construct a reality that will ensure its survival. This is the basis of epigenetic signaling that we now know to be the major genetic modifier of the genome of all animals.

The major signal transducer in Epigenetics is found in the cellular signaling in our cell membranes that interact with the environment and our inner hormones that signal our epigenetic switches sitting on our genes inside the nucleus. Since it is clear that our cold adapted pathways use sensory afferents to signal to open the Ancient Pathway, I think it is time we just have a blog in the CT series that discusses what a normal 24 hour day is like in a human circadian biology.

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The Osteoporosis Rx

Osteoporosis is a disease in which the bones become weak and are more likely to break. People with osteoporosis most often break bones in the hip, spine, and wrist. If you think this problem is not common, let me pick up the rock you must have been sleeping under. In the United States, more than 60 million people either already have osteoporosis or are at high risk, due to low bone mass.

RULE 1. If one is leptin resistant, Wolff’s law is null and void, and you are at very high risk for a fractured vertebrae or hip/wrist. You should stop here and go read EMF-8 Quantum Bone for the pathophysiology of this disease. The key features are to increase your spring water intake to 1-1.5 gallons of non fluoridated water a day and strict avoidance of artifical light and the use of pulsed EMF technology devices. This means that “normal conventional wisdom osteoporotic treatments” and exercise will not heal or strengthen a bone until the underlyig pathophysiology is repaired first. When a person has high levels of leptin, it eventually drives cortisol higher and this stimulates even more inflammatory cytokines from cells. As this occurs, LR develops all over the body. Cortisol is one of the major hormones involved in the sympathetic nervous
system. When cortisol is chronically high, as I told you in the Hormone 101 blog, it’s bad news. When someone is leptin resistant, they block osteocalcin’s main function and this causes osteoporosis. This is one major reason why fat people lose their bone. It also definitely proves that Wolff’s law is null and void when you are LR. Even resistance exercise maybe harmful when this occurs. Bone only strengthens when the underlying hormonal terroir is working properly. In LR, it is seriously broken.

RULE 2. Andropause and Menopause are associated with osteoporosis, and not caused by it. In both situations the best treatment to overcome it is to change your diet to a high fat and protein diet. You would be a wise patient to avoid all bisphosphonate drugs until it’s too late. This will be hard to do, because most clinicians will push drug treatments over evolutionary medicine treatments. Remember The Seven Dwarfs of menopause: Itchy, bitchy, sleepy, sweaty, bloated, forgetful, and all dried up…and the bones are real dried up!

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Osteoporosis 3: Related Drugs and Diseases

What are some of the medical conditions that are associated with osteopenia or osteoporosis?
1. Excessive alcohol intake- greater than two drinks a day consistently will do it.
2. Tobacco use- This causes a 100 fold increase in bone loss. Oral tobacco is worse than inhaled smoke
3. Stress- any cause be it emotional, physical, mental, psychic all raise cortisol chronically and kill bone
4. Lack of physical activity increases obesity risk, which increases cortisol from leptin resistance
5. Low calcium intake or absorption from gastrectomy or low acid production from any reason
6. Reduced strength and activity due to a chronic illness or a sedentary life (checked with a grip test)
7. Small build or leanness naturally – correlates with BMI below 19 for women and men.
8. Asian women have a particular propensity to osteopenia genetically and from their diet.
9. Drug therapy, for example, long-term use of corticosteroids such as prednisone-used to treat rheumatoid arthritis, asthma, celiac disease, autoimmune diseases, Crohn’s disease, IBD, and ulcerative colitis.
10. Low Magnesium, strontium, boron, Vitamin D3, Vitamin K2, elevated PTH levels, low sex steroid levels, high insulin levels, low progesterone levels, any cause of a leaky gut.
11. Menopause
12. Andropause
13. Any cause of chronic inflammation (perimenopause can cause severe acute bone loss)
14. Disuse atrophy from any cause (space travel)
15. Paralysis
16. High carbohydrate diets
17. Veganism or a plant based diet.
18. A diet high in whole grain (carbohydrates) is especially risky due to mineral malabsorption in gut
19. A diet lacking in animal protein and animal fat and cholesterol.
20. Excessive use of statins and thyroid hormone can cause osteoporosis
21. Age and sex: the older one is predisposes to osteopenia. Women lose 1-3% of their bone density ever year after their last period.
22. Chronic endurance athletics of any type cause severe bone loss due to chronic cortisol elevations
23. Gastric bypass patients carry enormous osteopenic risks.
24. Severe liver or kidney disease; Renal insufficiency can lead to osteodystrophy.
25. Diabetes
26. People with scoliosis of unknown cause (idiopathic scoliosis) also have a higher risk of osteoporosis. I believe this is because most of these children have severe underlying Vitamin D deficiency and a leaky gut, but this has never been studied in the spine literature. Any time I see a scolisosi patient, I always screen for low sex steroid hormones, low Vitamin D levels, and low Carboxylated osteocalcin levels. Bone loss can be a feature of complex regional pain syndromes.as they develop over time. It is also more frequent in people with Parkinson’s disease and chronic obstructive pulmonary disease as well.

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Osteoporosis Part 1

In my day job as a neurosurgeon, I operate on a lot of diseased spines. In the last 12 years, I have repaired over 1000 vertebral fractures from osteoporosis. If you remember back to my podcast with Jimmy Moore, I mentioned in the talk that the changes I had seen in osteoporosis incidence and prevalence is what made me look for the underlying cause. This ultimately led me to leptin and our diet. Many people think since bones are hard and used for support that they are not an active tissue. Bone is a very active tissue in the body that is constantly turned over. We constantly lay down new bone to stressors and resorb bone from areas that are not stressed. Since bone is so active, it uses massive amounts of energy. This is where leptin comes in. Any tissue that requires a ton of energy is coupled to leptin biochemistry. The story on bones and osteoporosis, however, is a very complicated one. I am going to give you a flavor of just how complicated. This osteoporosis series will have many twists and turns. Most seasoned spine surgeons wont know much of what you are going to learn here about bone. Most don’t know that osteoporosis is caused by leptin resistance. Just ask one and see if I am correct. Most will tell you to take Calcium, Vitamin D, and exercise a bit to treat osteoporosis. They may mention a Rx for a bisphosphonate class of drugs too. I don’t use these drugs at all. If you do just that, you can bet you won’t cure a thing and you might even make the problem worse. Spine surgeons are taught a law called Wolff’s law in reference to bone metabolism. It says the more stressed a bone is, the more bone is laid down and the stronger the bone is. This law is why most spine surgeons don’t think that obese folks will have osteoporosis when they come to see us, much less test for it. These are the people who are experiencing a silent epidemic of this condition. Their numbers have exploded over the last thirty years. I mentioned that in my career I have seen a tremendous increase in this disease. In medical school, I think I had a one hour lecture on this disease. Now it is involved in close to 80% of the cases I see in my clinic. Few spine surgeons expect to see osteoporosis in our younger patients because most think this is predominantly a disease of old women with low estrogen levels. We are not taught to look for it in its correct biologic context, so it is often missed as a diagnosis, but often found on MRI imaging as loss of mineral content and more fat present in the marrow space. Spine surgeons must be more vigilant about this disease, because if it’s tied to the leptin hormone, it points to the fuels we are putting in our Ferrari’s! I will show you why diet is a huge factor in the development of metabolic bone disease that you should consider. This is why I treat osteopenia and osteoporosis a lot differently than conventional wisdom you will hear from other sources.

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How Does The Leptin Rx Work?

Many people have contacted me about “why” the leptin Rx works and “how” does it work. Many people in the blogosphere have made some claims that much of what is in the leptin Rx is a rehash of the work found in some diet books. Well, today’s post is being done to show you the science underneath my recommendations were formulated and made. None of the underlying science I will mention to you about neuroplasticity will be found in any diet book mentioned in any blog post that I know of. Most of you know I am a neurosurgeon, and as such, I was dramatically influenced by two world famous neurosurgeons named Wilder Penfield and David Kline. Dr. Penfield was the first neurosurgeon to use electrodes on the brain to map it prior to surgeries to avoid neurologic damage during tumor removal. Dr. Kline was and still is the pre eminent world expert in peripheral nerve surgery. I happened to train with Dr. Kline in New Orleans, and got turned on to his work, Dr. Penfield’s work and the work of Dr. Merzenich in the early 1990’s before leptin was even discovered. Dr. Michael Merzenich work on sectioning the median nerve in the hand and seeing how the brain remapped its sensory territory in the cortex via micro-electrodes was brought to my attention by Dr. Kline while I was a resident.

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MSG, your GUT, and your BRAIN, Post-Trauma

READERS SUMMARY: 1. How does MSG and aspartame affect you and your brain and your fat loss? 2. What do artificial sweeteners do to a human? 3. How does neuronal injury from diet, trauma, and energy depletion all tie together? 4. What about young humans? 5. What about young humans with injured brains? In part 2 of this series, we will explore how excitatory amino acids in foods and introduced to our GI tract could cause us some problems with normal functioning causing weight plateaus. We will discuss how MSG and aspartame (Nutrasweet), could wreak havoc with the human brain. This is especially true if that brain already has been concussed many times or is afflicted with some neurodegenerative disorder or is connected to an already leaky gut (low HDL level). Many people don’t seem to understand how MSG and artificial sweeteners cause damage to neurons. The experimental data on this area is documented quite well by Dr. John Olney. His work began in 1969. He studied the endocrine effects of MSG on the hypothalamus. Most of my blog readers know that leptin signaling in the hypothalamus is critical for developing obesity and controlling weight among other things. You might […]

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The Leptin Rx: FAQs

What should I do before I start The Leptin Reset? Before you start, take a picture of yourself from all angles. Don’t be bashful or you’ll be sorry in 18-24 months. Next, weigh yourself naked. Let your significant other or a family member take this picture. Go to the store and buy a piece of clothing that does not fit you now, but will when you have met your goal. Remember, calories are important when you’re LR (leptin resistant) and mean nothing once you are LS (leptin sensitive). Macronutirents count when you’re LR and mean nothing when you’re LS.
How do I determine if I am leptin resistant? Remember, you can be LR (leptin resistant) if you’re fat or skinny. If you’re overweight by more than 30lbs, it is a lock you have some degree of LR. If you’re underweight by 20 lbs, you are likely LR, too. If you had an eating disorder, you’re likely suffering from a serious leptin issue.

The easiest test is to look in the mirror. The mirror does not lie and it is really cheap. For those people who still can’t be sure after peeking in the mirror, you can order some blood tests. My favorite is the HS CRP (highly sensitive C-Reactive protein) and the reverse T3 tests (but there are others). They are accurate in over 90% of cases.

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Your Gut, Neurotransmitters, and Hormones

READERS SUMMARY: 1. HOW YOUR GUT BRAIN AND RESPONSE OF YOUR BRAIN ARE ALL TIED TOGETHER? 2. WHAT ARE THE 4 MAIN NEUROTRANSMITTERS? 3. WHAT DO THEY DO AND MEAN? 4. WHAT AFFECTS THEIR PRODUCTION? 5. HORMONES ARE THE BRAINS ENDOCRINE SECRETION THAT TELLS YOU HOW YOUR EPIGENETIC SWITCHES ARE SET. 6. HOW WE USE HORMONE STAUTS TO FIGURE OUT WHAT IS REALLY WRONG WITH YOU? The next post in the series follows directly upon what we learned about the brain and ketogenic diets. Today we are going to mesh the brain gut axis and neurotransmitters so you can begin to understand how diet can modify your personality and your behavior. In severe cases it can also cause mental illness and eating disorders. In fact, if you have never heard of the GAPS diet you need to read a bit about it. Today I will lay out some of the biologic plausibility of how this occurs and some interesting clinical correlates to specific NT deficits from our diets. Everything in biology usually ties back to the brain at some point and this is very clear in NT biology. Neurotransmitters are involved in many neural circuits in the central and peripheral […]

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Hormones 101: Clinical thoughts revealed

Readers Summary Why I use highly sensitive C-reactive protein (CRP) and Vitamin D as biomarker proxies. After Leptin, Cortisol is the next most important domino to fall. Hormone Cascade explained in a paragraph. Unintended consequences of hypercortisolism destroy health. Initial HS CRP signals the genesis of underlying hormonal disruption (First sign Leptin is toast). Now that we have laid some foundation about Leptin at the “30 foot research level” (I know, I made your head hurt at times), let’s zoom out now and look at how this affects the hormones that dictate the things patients see and feel and sense about their bodies. I want to now give you some perspective as to WHY this matters We have established that as one gets fat, Leptin levels rise. Once they get high enough (around a Body Mass Index (BMI) of 20-24), Tumor Necrosis Factor (TNF) rises in several tissues. This also causes a rise of NF kappa beta and IL-6 in the brain.  TNF quickly destroys normal hepatic homeostasis, which sets the stage for fatty liver disease and type two diabetes over time. This rise in TNF also biochemically changes Leptin receptor signaling and changes its quantum properties by changing its […]

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Leptin Part Deux: Liver

Many people are under the assumption that the thyroid is the real key to metabolism. I can’t tell you how many meetings I have been to and heard this nonsense. It happened today while I was speaking to a dietician and nutritionist in a hospital. It’s just not correct. The liver is the engine of our body’s Ferrari! The thyroid is best described as the gas pedal for the engine and leptin is the electronic chip that controls the entire process. So we need to discuss some biochemistry now. Rub your head a few times before we start to increase your blood flow!

When humans eat a meal about 60% of the calories wind up in the liver to deliver energy to tissues between meals to sustain normal energy production. Another hormone, Glucagon, mediates this release of fuel. The remainder of the energy (40%) is sent packing to the peripheral tissues and the muscles where insulin allows the energy to enter the cells. If those cells are leptin sensitive they use all 40% of the calories with nothing left over. If they are leptin resistant the excess calories go directly back to the liver to be placed into fat storage (or stuck inside the liver cell) in fat cells because of the high insulin levels. The more fat that gets deposited, the higher leptin levels go over time. If the fat gets stuck in the liver it causes a large immune reaction driving up more inflammatory chemicals. When it gets to a critical level (different body fat levels for all people) the fat begins to make the bad stuff. (IL6 and TNF alpha)

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Please Note: The author of this site is not engaged in rendering professional advice or services to the individual reader. The ideas, procedures, and suggestions contained within this work are not intended as a substitute for consulting with your physician. All matters regarding your health require medical supervision. I shall not be liable or responsible for any loss or damage allegedly arising from any information or suggestions within this blog. You, as a reader of this website, are totally and completely responsible for your own health and healthcare.