Do You Have a Grain Brain?

READERS SUMMARY: 1. WHO IS DR. PETER UNGAR AND WHY ARE OUR TEETH A BIG DEAL? 2. WHAT DID GRAINS DO TO OUR BRAIN AND SKULL? 3. WHAT IS A CHIARI MALFORMATION AND HOW MIGHT IT BE TEETH RELATED? 4.. WHAT MIGHT BE THE REAL CURE OF SIDS (sudden infant death syndrome)? 5. WHY PHYSICIANS NEED TO ASK QUESTIONS ABOUT YOUR DIET IN A HISTORY AND PHYSICAL EXAM? I saw a very interesting case in the clinic last week, and I decided I had to write a short blog on it because I think it makes and elegant point of some of the evolutionary changes we have seen in Hunter Gather skulls and modern skulls as we have continued to eat grains. If you are not aware of the work of Dr. Peter Ungar, you should read some of his work. My fourth cite is his masterpiece book on mammalian teeth. It is quite interesting and helps tie what our diets have done to shape our skulls and our occlusions. He is an expert on the study paleolithic teeth. Since I am a past dentist, and a present neurosurgeon, his work really resonates with me. It has allowed me to […]

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MSG, your GUT, and your BRAIN, Post-Trauma

READERS SUMMARY: 1. How does MSG and aspartame affect you and your brain and your fat loss? 2. What do artificial sweeteners do to a human? 3. How does neuronal injury from diet, trauma, and energy depletion all tie together? 4. What about young humans? 5. What about young humans with injured brains? In part 2 of this series, we will explore how excitatory amino acids in foods and introduced to our GI tract could cause us some problems with normal functioning causing weight plateaus. We will discuss how MSG and aspartame (Nutrasweet), could wreak havoc with the human brain. This is especially true if that brain already has been concussed many times or is afflicted with some neurodegenerative disorder or is connected to an already leaky gut (low HDL level). Many people don’t seem to understand how MSG and artificial sweeteners cause damage to neurons. The experimental data on this area is documented quite well by Dr. John Olney. His work began in 1969. He studied the endocrine effects of MSG on the hypothalamus. Most of my blog readers know that leptin signaling in the hypothalamus is critical for developing obesity and controlling weight among other things. You might […]

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Your Gut, Neurotransmitters, and Hormones

READERS SUMMARY: 1. HOW YOUR GUT BRAIN AND RESPONSE OF YOUR BRAIN ARE ALL TIED TOGETHER? 2. WHAT ARE THE 4 MAIN NEUROTRANSMITTERS? 3. WHAT DO THEY DO AND MEAN? 4. WHAT AFFECTS THEIR PRODUCTION? 5. HORMONES ARE THE BRAINS ENDOCRINE SECRETION THAT TELLS YOU HOW YOUR EPIGENETIC SWITCHES ARE SET. 6. HOW WE USE HORMONE STAUTS TO FIGURE OUT WHAT IS REALLY WRONG WITH YOU? The next post in the series follows directly upon what we learned about the brain and ketogenic diets. Today we are going to mesh the brain gut axis and neurotransmitters so you can begin to understand how diet can modify your personality and your behavior. In severe cases it can also cause mental illness and eating disorders. In fact, if you have never heard of the GAPS diet you need to read a bit about it. Today I will lay out some of the biologic plausibility of how this occurs and some interesting clinical correlates to specific NT deficits from our diets. Everything in biology usually ties back to the brain at some point and this is very clear in NT biology. Neurotransmitters are involved in many neural circuits in the central and peripheral […]

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The Leaky Gut Prescription

Well, we have talked about the gut in three other blogs so far. (1) Could It Be the Gut?: An Introduction to the Brain-Gut Axis, (2) Your VAP = Brain Gut Axis Function, and (3) Why Leaky Guts Lead to MS? Click those links or go to my home page under Brain Gut Axis and find each one for a quick review. We have hinted at the leaky gut as a cause of serious human disease in all those posts. Today we get to focus on the “leaky gut” and how we might offer to treat it.

What is a leaky gut syndrome? It is the complex biochemical reactions that occur in the gut appear to be the genesis of where inflammation initially passes in to our body. We need to realize this and avoid eating the things that cause this inflammation. As I have said for close to five years now this means strict avoidance of omega 6’s, all grains and especially wheat of any kind and very limited fructose (fruit or synthetic sources) The gut associated lymphatic tract (GALT) is the first place where our immune systems interact with the outside world. This occurs right below the intestinal brush border and is our first line of defense. It seems to me that evolution has dictated that this is precisely where the battle between health and disease begin in humans and why our immune system is set up ready on that battle front.

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WHY LEAKY GUTS LEAD TO MS?

READERS SUMMARY: 1. What determines our ultimate health fate? 2. What exactly is epigenetics? 3. How does an autoimmune disease begin? 4. Is multiple sclerosis tied to gut inflammation? 5. What is an inflammasome and why is hypomethylation so critical? My first post on epigenetics seems to have stimulated a lot of talk based upon the emails I received. I think we need to dig a bit deeper into this area because it is now clear scientifically that epigenetics really determines our ultimate health outcomes. In fact, it is the easiest way to alter our genomes by modifying our dietary choices. To begin let’s simply define what epigenetics is in 2011. Epigenetics is any mechanism that affects genes without chaining the nucleotide sequence of the DNA. The two major ways epigenetic modification occurs via our diet is via methylation of our DNA or of acetylation of our histone proteins. The amount of methyl and acetyl groups come from our diets. For example, when we have low methylation in our diet, our DNA becomes hypomethylated. Lower levels of methylation correlates with development of higher rates of cancer and with autoimmune conditions. Obviously, none of us wants to get cancer or autoimmune […]

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Can’t Remember? Is Your Protein Bent?

READERS SUMMARY: 1. Alzheimer’s disease is due to lack of electrons which causes compliant design changes in protein phosphatase! 2. Why is the incidence and prevalence growing for AD? 3. What is a proteopathy? 4. Why is protein folding so critical to so many diseases? 5. What kind of nutrition guidelines do I follow to avoid AD doc? Many of you had questions after my first Alzheimer’s Disease post (AD) but few seem to want me to call the cause of it. The truth is no one is willing to make the leap of faith just yet, but the data that we have found over the last ten years has given us a pretty good idea of what causes it to occur. I am not going to be so kind. AD is the major neolithic disease coming for People 0-40 years old today. No neolithic disease we have seen be born in the last 125 years will have the impact on our society that AD will have. Humans evolved from other hominids because of their brain and how they rely on social learning. AD completely destroys that beautiful adaptation. Many younger people think that AD is a disease of the […]

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WHAT IS BIOLOGIC CONCRETE?

READERS SUMMARY: 1. What is glycation? Why should I care about it? 2. What are the signs I can see if I am doing this to myself without my doctor? 3. What are the steps in glycation and where will it lead me? 4. What are the consequences if I ignore this biologic process? We established in the Quilt what glycation is. Today we are going to talk about the clinical manifestions of glycation so that you can begin to assess yourself for the signs and symptoms. If they are present then we can give a strategy to stop the progressive damage so you can avoid the ravages of neolithic disease progression that Americans currently face. First we have to get you to write some answers down to some questions. Get a pen and paper. Read on and write the answers as you go to see how much biologic concrete you may have collected so far. The first sign to look for are found in the mirror. Take a good look at your skin. Does it look like it did when you were in third grade? If not, you likely have a problem. AS you look can see well?  Do […]

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Your VAP = Brain Gut Axis Function

When most people get a VAP they think heart and lipid study. I do not. I use this test to assess levee 5. Most people in the paleo world associate a leaky gut with a gluten problem. I do not. The VAP test is the best test to use to assess the function of our gut and how leaky it is based upon the fuels we are feeding it now. If you really dissect your VAP you can learn a lot about what you should be eating and you should not be eating based upon your current cellular homeostasis. Most people think a diet is static. I believe a diet must be dynamically altered based upon the testing feedback we receive from our body. As most of you know I use a quarterly lab draw system to assess my own health to make dynamic changes as I see fit. So today let’s talk about the uses of a VAP test.

The basis of the brain gut axis is the protective effects of great liver function. I think the real defender of “leaky gut” is not the brush border of the intestine but it is the liver. Why? All humans are subject to direct assault of inflammation via our intestines because it is the most common way the environment reacts with our body. This is also why the immune system is ready for defense right behind the brush border. We already know that diseases like celiac destroy this first line immunity. Well, a good liver will protect a leaky gut and the brain. Most endotoxins gain access to our portal circulation but they rarely ever get to our general circulation to cause the real damage because our liver won’t allow it to occur based upon its design. In fact, endotoxin binding in the liver is increased by exercise, testosterone, estrogen and even occasional alcohol use. These things all increase our HDL particles too. A high HDL is a sign of good liver function. Remember that HDL particles actually bind inflammatory endotoxin particles to increase our immunity from oxidation from many sources. This is why a high HDL level confers general health and well being across the board. Moreover, VLDL and chylomicrons also protect us from inflammatory damage as well. This biologic process is at the seat of why we see higher cholesterol levels in the face of cellular stress or infection.

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AVOIDING FATES OF RONALD REAGAN OR MICHAEL J FOX.

READERS SUMMARY: 1. Why the presence of genes means nothing to disease risk. 2. What do people over 100 years old teach us about genetics? 3. What six pieces of evidence found in 2011 tell us about AD or PD etiology? 4. How will industry try to solve the mystery? 5. What you can do right now to obliterate your current risk of AD and PD? If you did not know that Ronald Reagan suffered and died from end stage Alzheimer’s, you do now. Micheal J. Fox is afflicted with Parkinson’s disease and trying to solve its etiology as a fundraiser. Recently in 2011, several announcements were made that several genetic mutations seem to predispose us to Alzheimer’s disease (AD) and Parkinson’s Disease (PD). I tend to glance over these findings often because based upon my current understanding, genetic mutations are not where science seems to be headed these days. Genetic determinism has been the dogma for the last 50 years, but the most recent data suggest that we can reprogram our genes by turning on and off their function if we know how. This makes sense considering that most biologic systems don’t rely on the presence or absence of […]

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SLEEP YA BIG DUMMY

READER’S SUMMARY: 1. Every wonder why we use blankets to sleep? 2. Quick overview of how the hormones of sleep and metabolism are yoked. 3. See how several levees of the quilt are tied together. 4. Why the brain really needs to be understood for optimal health. Today is a quick hitter post for those who are trying to regain leptin sensitivity. I have gotten many PM’s on my Dr. Jack Kruse Facebook page and a ton of requests via twitter (@DrJackKruse) and by email to post a synthesis post on how several levees tie together for metabolism and sleep. I would strongly recommend that you re read the first leptin and sleep blog to review some of the material as a nice primer. Ok, so off we go. 1. Body temperature is controlled by the hypothalamus in the brain and it also controls leptin status and sensitivity centrally via the hypocretin neurons (HCN). The HCN also help modulate our sleep by keeping the stages in order and working optimally.  Cold temperatures are linked to magnetic effects of oxygen in our blood at night. 2. So you ever wonder why we “like” to wear blankets when we sleep?  Well, the […]

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DEVELOPMENTAL ORIGINS OF DISEASE

The basis of epigenetics is founded in fetal development and is heavily influenced by grand maternal and maternal behaviors that influence in utero life of the fetus. This influence seems to be multigenerational as well because of the inheritance of meiotic stem cells in females. It has been known for years that the mother’s behavior during pregnancy clearly effects the child’s outcomes when born. The extent of this effect however has never been studied in depth until recently. It appears that the mother’s diet, metabolism, and exercise status during pregnancy has profound effects on the fetus’s mitochondrial DNA programming and likely set the “epigenetic switches” on the child’s DNA. These changes seem to set the child up for neolithic diseases and the chronic diseases we see in America today. For the last thirty years childhood obesity studies have shown a dramatic change in NHANES curves that measure obesity in children. This spike corresponds to the amount of nnEMF man has created. We now see young children and infants with chronic diseases that adults used to get later in their life. Most of the focus of researchers in childhood obesity, like Robert Lustig, have focused in on postnatal environmental factors in […]

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PALEO 3.0, MEET EPIGENETICS

READERS SUMMARY: 1. What dietary context really means. 2. What is epigenetics? 3. How a thread can help thousands of people? 4. Sharing thoughts can really help us all out. 5. How did grandma and mom turn off or turn on your metabolism? And what have you done to it recently? The Quilt took me years to lay out in my own mind based upon my experiences as a surgeon. Sometimes it is really neat when I get a bolt of lightening from a person that I am communicating with. That occurred this AM when I was giving some feedback to a fellow “netitizen” on a forum about his labs he posted. My inclination was not to really give my feedback because I tend to be a polarizing presence at this place. But based upon some of the responses in the thread and the “ambient awareness” I have with this particular poster over the net for the last 6 months, I decided it was prime blogging landscape. Some background is needed. Mr. Kronk posted his VAP (lipid profile) on a website and asked for feedback. Since I have been interacting with this particular person for sometime I think I have […]

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WHAT MIGHT CASEY ANTHONY AND OJ HAVE IN COMMON?

Do you have dark circles under eyes? Are your eyes sunken to some degree? Do you sleep poorly? Have you lost your energy? Sex drive gone? Do you bloat and start getting unusual bowel movements? Do you live in a plateau phase constantly? Has your weight remained the same too long? Tired for no reason? Need to drink a ton of coffee and salty carb snacks to get by? Do you still crave sweets? Do you feel generally rundown? Do you exercise a lot but still have belly fat that is resistant to loss? Are you forgetful often? Hair loss or brittle? Diagnosed with GERD (dysbiosis) and feel nervous often? Often depressed? If this sounds like you welcome to the diagnosis of adrenal fatigue. Many conventional docs don’t buy this diagnosis but that is because they can’t see what they are not looking for.

This syndrome is most often seen in middle age women and can present with multiple endocrine changes that are often confused with thyroid issues or perimenopausal changes. Men do get this syndrome and most often it is seen with dietary issues and fatigue from working out or from chronic stress.

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CANCER HITS, WHATS NEXT?

READERS SUMMARY: 1. What to do when you get a new cancer diagnosis? 2. Is the main cancer battle field oncologic treatment or in your own body? 3. How does diet play a role? 4. How to deal with your new doc the oncologist? 5. Do not be afraid of exploring every possibility to win this battle. Learn about a ketogenic diet!!!   Before you read this blog watch this video:  HYPERLINK This post is for one of my very special dear friends who just contacted me and told me his wife got diagnosed with cancer at a very young age this week. I could hear from the call and his post on Facebook this was killing him. I told him immediately to go out and buy the book the Anti Cancer: A new Way of Life by David Servan Schreiber and give it to his bride. The good news is that many of the 6 million people being treated for cancer today will go on to live a full life. The numbers of those who do survive in my opinion are still far too low (about 45-50%). Moreover, many of the close to 2000 cancers deaths that occur daily […]

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Could It Be the Gut?: An Introduction to the Brain-Gut Axis

READERS SUMMARY: 1. What is the brain gut axis? 2. What diseases likely are tied to its breakdown? 3. Why might medical training force us to miss the importance of this axis? 4. How did I discover the brain gut axis in my own clinical practice? 5. Did evolution dictate where the initial battle of immunity should lie? When many doctors hear me talk about the brain gut axis I get lots of funny looks. See, this is an axis that we do not formally learn about in anatomy in medical school. We learn about systems in anatomy that are organized as tissues within organs. Physiology is where organ integration and its function is taught. Guess what? We did not learn about the brain gut axis there either. In fact, when I was in medical school and residency, I never once heard or attended a lecture of this axis that I believe is the fifth most important levee in my cellular theory of health! I personally believe that medicine is going to revolutionized by the science that is uncovered in this axis over the next few decades. I believe the diseases that currently have no cure or known cause will […]

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