Hormone CPC #1: DHEA

Print pagePDF pageEmail page

Readers Summary

  1. What is the state of affairs of DHEA in medicine today?
  2. How should you handle DHEA for you since it was reclassified in 1994 as a supplement?
  3. Does it work?
  4. What does it do in a body?
  5. Who might it help?  Who might it hurt?  Should I talk to my doctor about it?

This blog post was created for my members who just heard my webinar on bioidentical and synthetic hormone replacement.  It is specifically designed to further our discussions in that talk.

DHEA has been an enigma to the public and to most physicians.  I never once heard about this hormone in four years of medical school, seven years of residency or in any endocrinology lecture from my training. The general public did not learn about DHEA until 1996, when its benefits were mentioned in the media and several popular books that showed up on daytime TV shows. Most in mainstream medicine continued to ignore the science these books contained because they were not found in the usual ways via journals and continuing education classes. You actually had to be on the lookout for this information. With a busy medical practice, this is no easy task. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book called DHEA and Aging. That book provided scientific validation for the many life-extending effects of DHEA.  DHEA is linked to solar exposure by way of Lutenizing Hormone in both sexes.

IMG_8416

DHEA Hormone Review

DHEA (dehydroepiandrosterone) is a steroid hormone produced by the adrenal glands. It’s a precursor to both testosterone and estrogen in the body, although it may play other physiological roles as well. In my hands, I used DHEA level as a proxy for a person’s environment and how it affects their redox potential.  In post menopausal women, the only way they make sex steroid hormones is from adrenal enzymes and the aromatase enzyme in fat cells. There are many studies of oral and IV routes that have given us all conflicting reports of efficacy. Topical DHEA use may be another story for women, however. Recent studies have demonstrated that intra-vaginal application of DHEA cream could alleviate age and menopause-associated vaginal atrophy. It also can improve sexual function without altering serum hormone levels significantly, and is the most potent way to stimulate sleep when some one is sleep deprived because of its effects on the IL- 6 cytokine.

In 2012, even modern healthcare is beginning to realize that chronic inflammation is linked to just about every neolithic and aging disease known to mankind. Both of these disease processes have rising inflammatory cytokines as the main causes of their progression. These chemicals are destructive to cell membrane signaling, cellular nuclear processessing signaling, and cytosolic signaling. They have particularly devastating affects on the steroid hormone receptors and the receptors of both arms of the immune system. These errors in signaling lead to disease progression. Some examples of these cytokines are TNF-alpha, IL-6, IL1b, and LTB4 on the inflammatory cascade. We have known from Cutolo’s 2000 study that most adrenal hormones (like DHEA) are very low prior to development of the full blown disease. This is true in all autoimmune diseases, especially rheumatoid arthritis.

DHEA has been shown to prevent chronic inflammation and it slows the abberant signaling that is commonly found in the immune system when it is turned on by any pathogen, self or foreign. DHEA is particularly helpful in limiting IL-6 and TNF alpha in both disease propagation and in normal human aging.

DHEA has been shown to have dramatic affects on those infected with serious viral illness like HIV and Hepatitis C. Part of the reason for this affect is because in both of these diseases, we see a loss of Type 1 cytokines from cell mediated immunity (gamma Interferon and IL-2) and an excess of Type 2 cytokines like IL-6. This steep rise in Il-6 is fought back by the available DHEA until its production falls and causes dramatic rises in cortisol. The drugs used to treat both conditions are called protease inhibitors and when they are used in either disease, DHEA levels dramatically rise to help stimulate the immune system. Many physicians are completely unaware of the the effects of the hormone on immunity.

In my practice as a neurosurgeon, I use DHEA replacement often in post trauma cases or post brain tumor cases to improve cognitive function and memory. Replacement of proper DHEA levels actually improves EEG recordings in these patients. A study done at UCSD by Dr. S.S.C. Yen showed the remarkable effect of a low dose of DHEA (50 mgs a day for 6 months) restoring DHEA levels in men and women while dramatically improving their perceived physical and psychological well being for both sexes. I have found in many trauma and brain tumor cases, DHEA was the easiest way to elevate IGF 1 levels to improve growth hormone secretion without expensive replacement. When IGF 1 levels are in the upper quartile, we see massive improvements in lean muscle mass, decreased abdominal fat, improved immune function, and improvement of cognition and memory.

DHEA also improves cardiac function and atherosclerosis. You can review the 1996 journal article Drugs and Aging by Dr. Watson that correlated low DHEA with several human cancers, loss of sleep, decreased sense of well being, and increased feeling of death. DHEA also improved bone cell function, lymphocyte function, improved cardiac function, and helped T2D as well. The study also reported no toxic doses when used to restore humans back to youthful levels and production. The study appeared to show a link between low DHEA and all diseases of aging in humans, poignant because the neolithic disease we are seeing today are occurring earlier. DHEA levels may be a very earlier marker for poor metabolic functioning of many systems. This study caught my eye years ago, inspiring me to test DHEA levels to help me assess patients when I work them up in my clinic.

DHEA is abundant in the human brain, which manufactures it in high quantities. DHEA levels are a great clinical proxy for depression.  The DHEA levels in many of our troops returning from the Middle East’s wars are horrendous when tested. It is no wonder we are seeing a massive spike up in PTSD and suicide in these troops. They are the first generation of soldiers feed an exclusively neolithic diet their entire lives before combat.  Their risks would be expected to be the highest because they likely had the highest cortisol and lowest DHEA levels before entering the theatre of combat. DHEA and cortisol are the two most common hormones linked to depression in most studies who look at hormones and these diseases (Goodyear et al 1996, and Barrett-Connor in 1999).

DHEA and sunburn protection

Many people in the paleo community talk about how they rarely seem to need sunscreen after changing their diet to an anti-inflammatory, paleolithic diet.  This is because their DHEA levels have dramatically risen with the lifestyle change. Burn literature has been telling us for 20 years that if one applies topical DHEA cream to a serious burn, the blood vessels underlying the burn become protected and stimulate healing (Araneo et all, 1995). Many people might remember that I went surfing the day before AHS 2011 in Santa Monica, and I got really pink to red. Several people mentioned that because I was fair, I would likely be sporting a nasty peel soon. I told several of the people at UCLA my little trick for avoiding all sunburn peeling after a bad exposure: topical use of a DHEA cream I had formulated. When you protect the blood vessels below the burn, the DHEA does not allow that skin to undergo apoptosis and it actually saves your dermal stem cells. It actually prevents wrinkling, too! I wish I had known this when I was younger, but that is how the science ball bounces.

Similarly, DHEA can stimulate pro-collagen production and may have beneficial affects on aging skin. All these are very important indicators for peri- and post-menopausal women. Older women can be incredibly sexy when they find their groove, and DHEA is a big part of why Stella found her groove, in my opinion. In women, DHEA replacement topically decrease TNF alpha in the skin to destroy inflammation locally. If you ever meet my wife, you will see the affect. She does not look her age at all. DHEA will also thicken a woman’s skin, too, with time. I use this trick when I am cutting on a woman’s head or neck, and some of my plastic surgeon friends have really become enamored with topical DHEA use for peri-operative swelling and recovery. I used DHEA cream to help rid myself of the nasty red stretch marks from being morbidly obese. I do not have one red stretch mark left on my body.

The last four years have produced a torrent of positive research findings concerning DHEA. The results on the immune modulation of this hormone on the cortisol /melatonin/ cell-mediated immunity axis is just amazing. Most HIV patients with doctors who are dialed in can attest to the positive effects of this hormone on many of their functions when conventional medicine has few solutions. DHEA is produced by the adrenals in healthy young adults (usually below 35) , but its levels decline dramatically with advancing age in both sexes, coinciding with the onset of numerous diseases of aging. The one thing that coincides with the destruction of this hormone level is the onset of cellular inflammation.

While DHEA’s demonstrated anti-aging benefits have made it a popular adjuvant in the baby boomers, new data supports DHEA’s critical role in alleviating depression, enhancing endothelial function, preventing atherosclerosis, increasing bone mass, slowing osteoporosis, improving insulin resistance, and even hastening wound healing in surgical cases. Yes, I do use this supplement a lot in my surgical cases where there is a documented deficiency. It supports recovery by improving sleep quality and quantity.

Despite its list of health benefits, however, DHEA remains under U.S. Congressional assault. It is often called an “anabolic steroid” and has led some in Washington to call for outlawing DHEA outright.  It was banned for sale in 1985 and then 9 years later, reclassified as a supplement.

It has been shown that the serum hormone DHEA often declines by 75–80% from peak levels by age 70 or later, leading to hormonal imbalances that can affect one’s quality of life. Peak blood levels of DHEA occur around age 25 when inflammatory levels are low, decreasing progressively thereafter. The marked decline in serum DHEA with age is believed to play a role in health problems associated with aging and loss of immune system functioning. People with autoimmune diseases have some of the lowest DHEA levels I have tested.

DHEA will cause a 20% bump up in IGF-1 levels, too, without expensive HGH.

DHEA increases monocyte numbers by 35%. These are antigen-presenting cells in our body that improves our immune surveillance.

DHEA increases B Cells by 29%, but more importantly, it increase B cell function by 62 %.  Anyone with an autoimmune disease might be interested in that.

DHEA increases T cell activity by 40%, but the T-cell numbers are not increased as other immune cells where. It also increase IL-2 by 50% and this is what increases T-cell function. Natural killer T-Cells, important in fighting cancer, were increased by 22-37% in numbers and their activity was elevated 45%. In all of these immune studies, DHEA has never been shown to cause any adverse affects. The pharmaceutical drugs that all act similarly to DHEA cost thousands more, are less effective, and have huge side effect profiles. I’d suggest googling Remicade or Enbrel to make a just comparison.

Since the early 1980s, several hundred studies have been published on DHEA’s various benefits, including immunomodulatory properties as well as positive effects on mood, quality of life, and body composition. It has been proposed that restoring the circulating levels of DHEA to those found in young people may improve well-being and sexual function. In a recent, randomized, double-blind, placebo-controlled study, ten months of DHEA replacement therapy has the beneficial effect of increasing muscle mass and strength with the addition of resistance exercise in elderly individuals. The studies of DHEA therapy in women with adrenal insufficiency also suggest beneficial effects on well-being, mood, and sexuality. DHEA benefits the normal aging brain by increasing progesterone, testosterone and estrogen levels to help cognitive function. Some studies have reported DHEA may improve mood and alleviate melancholy. In addition, recent studies in vitro have shown that DHEA has the capacity to improve endothelial function by increasing nitric oxide (NO) synthesis.

In recent randomized, double-blinded, controlled trials, DHEA replacement therapy for one year helped protect hip bone mineral density in older adults and spine bone mineral density in older women. DHEA has also been shown to support a healthy circulatory system and joint/bone health.

DHEA for osteoporosis

One fairly clear-cut benefit of supplementation of the adrenal-gland hormone DHEA is increased bone density. This is a condition that I treat daily without the normal Rx most physicians use for this condition.

Here’s one study showing very persuasive effects of DHEA supplementation, 50 mg per day for 12 months, on bone density: Effects of Dehydroepiandrosterone Replacement Therapy on Bone Mineral Density in Older Adults: A Randomized, Controlled Trial.

70 men and 70 women were given DHEA 50 mg per day vs. placebo with pre- and post- measures of bone density made. Women made dramatic improvements over the men in this study. Go look at the paper and see the charts for yourself. To achieve these results, women increased DHEA blood levels to 225-300 mcg/dl, while men increased DHEA blood levels to 300-400 mcg/dl.

This study corroborates findings made by a Washington University group and a University of California group that also showed increased bone with DHEA supplementation.

DHEA usage and safety precautions

I have been investigating DHEA for years and I began using it myself when my own levels fell several years ago. DHEA directions for use are specially drafted by your doctor to get you to optimal, and those dosing regimens can often be found online or directly from your doctor. I would suggest you show your levels to your doctor to see if they are correct for you.

The standard blood test to evaluate DHEA status is one that measures DHEA sulfate levels (DHEA-S). The DHEA-S is calculated in micrograms per deciliter (μ/dL) of blood. A DHEA-S (dehydroepiandrosterone sulfate) blood test may be taken three to six weeks after initiating a DHEA supplementation regimen to help determine optimal dosing.  Sun exposure between 8-11 AM can sulfate skin lipids best.  When having your blood tested for DHEA, blood should be drawn three to four hours after your last dose. I like AM dosing of this hormone (matches sun exposure), but I also have few problems with salivary testing of this hormone. This is often done with a salivary cortisol level to get an ASI (adrenal stress index) ratio. DHEA testing may save you healthcare dollars for many diseases if you are found deficient on testing. Most Crossfitters I have seen rarely have a normal DHEA.

Because of the overwhelming evidence connecting low levels of DHEA to problems associated with aging, I suggest that all people over age 40 begin DHEA therapy. For most people, the starting dose of DHEA is between 15–200 mgs, taken in one daily dose. Many studies have used a daily dose of 50 mg. Women tend to use the 7-keto DHEA form and men can use the regular DHEA form. WHY? 7-Keto DHEA is not converted into estrogen or testosterone, so it may be safely taken by women with hormone-dependent diseases like breast cancer.

Scientific studies have shown that 7-Keto can help people burn fat through a process known as “thermogenesis.” Most of you know that I am particular keen on anything tied to thermogenesis.  This means the body’s metabolic rate is accelerated, generating heat and energy that consumes calories and burns fat. 7-Keto accomplishes this by boosting the levels of three liver enzymes that stimulate fatty acid oxidation.

Ideally, DHEA replacement therapy should begin with blood testing to establish a base range. Since almost everyone over age 35–40 has lower-than-optimal levels of DHEA, most people begin supplementation and test their blood DHEA levels later to make sure they are taking the proper dose. The more technology with blue light people use the lower the DHEA rate will be.  Normal serum reference ranges and ideal ranges of DHEA-S are:

Normal Ideal:
Men 280-640 μ/dL 500-640 μ/dL
Women 65-380 μ/dL 250-380 μ/dL

People over age 40 who do not supplement with DHEA usually have serum levels below 200, and many are below 100, as a steady decline takes place after the third decade in life. There are different precautions for men and women that should be observed.

DHEA precautions for men

Before attempting to restore DHEA to youthful levels, men may want to know their serum PSA (prostate specific antigen) level. Personally, I no longer do this based upon the latest meta analysis from the urology literature on prostate cancer. It appears that PSA is not the gold standard as it was in years past. Many doctors still are not aware of the changes in urologic literature, but you should be. Nothing replaces a doctor visit and a good rectal exam for a prostate screening. I also strongly recommend a ketogenic version of my diet with a large amount of protein from seafood to offset any prostate cancer risk. When I get to Brain Gut 4 and Brain Gut 5 in the current series, I think you will see why. Men with prostate cancer or severe benign prostate disease may need to speak with their urologist before starting DHEA since it can be converted into hormones their doctors may want to monitor.

When taking DHEA, I also recommend taking the following other nutrients:

  • Vitamin E (d-tocopheryl succinate) 400 IU daily, Gamma E Tocopherol 200 mg daily
  • Selenium 200 mcg daily from one raw brazil nut
  • Lycopene from tomatoes daily in sauces
  • Consider Saw Palmetto Extract 160 mg twice daily
  • Nettle Extract 120 mg twice daily if HS CRP is chronically above 1.0
  • Boron 3–10 mg daily (for those with serious osteoporosis)
  • Increase seafood intake dramatically

It is important for men over 40 to ask their physician to check their PSA and DHEA-S serum levels every six to twelve months thereafter. Men should also periodically check their blood levels for free testosterone (not just a total) and estrodiol to make sure that DHEA is following a youthful metabolic pathway.

DHEA precautions for women

Women should consider estrogen and testosterone testing when they take their DHEA blood test in order to evaluate DHEA’s effect on their blood levels of these hormones.

Women who have been diagnosed with an estrogen-dependent cancer should consult their physicians before beginning the DHEA restoration process. This is controversial for many physicians. I have no controversy in my own mind any longer on this.

When taking DHEA, your doctor may also recommend taking the following other nutrients to maintain a healthy balance:

  • Melatonin 300 mcg to 3 mg nightly (I like checking salivary levels first)
  • Vitamin E 400–800 IU daily (d-tocopheryl succinate)
  • Broccoli extract 400 mg daily (as found in Dual-Action Cruciferous Vegetable Extract)
  • Indole-3-carbinol from cruciferous veggies like broccoli, cauliflower, or brussel sprouts
  • Vitamin D3 daily (dosage based upon levels)
  • Gamma Tocopherol 200 mg daily
  • Increase seafood intake

DHEA supplementation:

Look for DHEA supplements that conform to the following specifications:

  • Micronized (for maximum absorption and utilization)
  • Manufactured under GMP (Good Manufacturing Practice) conditions

Amount Per Serving
Dehydroepiandrosterone (DHEA)

15 mg to 200mgs, depending upon your physician’s advice. Do not use a podcast as a dosing guide. Recently, I had to treat someone who got real bad advice from an ‘untrained guru’ about this very issue.

Other ingredients to watch for: rice flour, wheat, and soy gelatins. Micro RNAs are not good news for our epigenome, in case you did not follow the comments in Brain Gut 2.

DHEA and heart disease: The LPa link its effects on Lipoproteins just recently studied at the University of Pennsylvania. DHEA supplementation is among my favorite ways to deal with the often-difficult lipoprotein(a), Lp(a) that is rarely covered in the blogosphere.  Supplementation, however will not work in an environment that is toxic with blue light.

DHEA is a testosterone-like adrenal hormone that declines with age, such that a typical 70-year old has blood levels around 10% that of a youthful person. DHEA is responsible for physical vigor, strength, libido, and stamina. It also keeps a lid on Lp(a) levels. I bet you learned something there! If you are “tracking your plaque,” you might want to check your DHEA level. Most people with bad vessels and hearts have terribly low DHEA levels, in my experience.

While the effect is modest, DHEA is among the most consistent for obtaining reductions in Lp(a). A typical response would be a drop in Lp(a) from 200 nmol/L to 180 nmol/L, or 50 mg/dl to 42 mg/dl–not big responses, but very consistent responses. While there are plenty of non-responders to, say, testosterone (males), DHEA somehow escapes this inconsistency, so monitor your levels and responses!

Rarely will DHEA be sufficient as a sole treatment for increased Lp(a), however. It is more helpful as an adjunct with a good Epi Paleo diet or you can use Krill Oil, high-dose fish oil, refrigerated fish oil, Vitamin K2 in amplified dosing, or niacin. I suggest talking these all over with your doctor before jumping in yourself. These supplements can be helpful for getting off a statin, particularly if you can’t tolerate them because of the CoEnQ10 depletion.

For DHEA, the “usual” 50 mg dose can make many people aggressive. You may want to begin with a lower dose and titrate it up for effect with your doctor’s blessing. Many people start with 10 mg. One can then increase to higher doses gradually over time, provided the edginess does not rear its ugly head. I can take quite a large dose without any side effects of this hormone, but you must realize not all of us can do that.

The data documenting the Lp(a)-reducing effect of DHEA are limited, such as this University of Pennsylvania study, but in my real-life experience treating many people with elevated Lp(a) levels, I’ve experienced it lowering your risks.

Personally, I take 150mgs a day, based upon my testing, and it varies by season!

Dosage and Use: The exact number of capsules to be taken should be determined by blood testing and the advice of a healthcare professional.  Generally, take one to three capsules in the morning. If your gut is bad, you can do topical or sublingual dosing

Do not take in the evening, as it could interfere with sleep (note: this is very rare, in my experience).

Caution: Do not use DHEA if you are at risk for or have been diagnosed with any type of hormonal cancer such as prostate or breast cancer on your own without professional advice! Just because it is an over-the-counter medicine does not give you carte blanche to use this adjuvant medication with impunity. Talk to your doctor about it.

For Webinar folks who heard today’s lecture, here are the links I promised for the talk we covered:

  1. http://www.webmd.boots.com/menopause/news/20120522/hrt-and-breast-cancer-risk-re-assessed
  2. http://www.medpagetoday.com/OBGYN/HRT/31394 (destroying the myths of the WHI)
  3. http://www.lancet.com/journals/lanonc/article/PIIS1470-2045%2812%2970110-9/fulltext
  4. http://www.pbs.org/newshour/rundown/2012/05/new-online-tool-helps-women-map-their-menopause-symptoms.html
  5. http://www.hormone.org/MenopauseMap/ (awesome for all women)
  6. http://www.shmirshky.com/menopause-blog/2012/06/11/menopause-mondays-testosterone-therapy-prostate-cancer-with-dr-josh-trutt/ (great info for men and HRT and prostate CA)
  7. http://www.latimes.com/health/la-he-estrogen-breast-cancer-20120307,0,1238385.story (estrogen alone therapy)
  8. http://www.bloomberg.com/news/2012-03-06/estrogen-only-hormone-therapy-may-protect-against-breast-cancer.html (estrogen alone)
  9. http://www.healio.com/endocrinology/hormone-therapy/news/print/endocrine-today/%7B88A0A2F3-D193-4B82-B5F8-2B7A0B16B529%7D/HT-safe-during-menopause-when-tailored-to-individual-patients (Menopause Society endorses BHRT now)
  10. http://www.drugstorenews.com/article/watson-launches-authorized-generic-menopause-drug?utm_source=GoogleNews&utm_medium=Syndication&utm_campaign=ManualSitemap (prometrium is now generic)
  11. http://www.bohrf.org.uk/downloads/Womens_Experience_of_Working_through_the_Menopause-Dec_2010.pdf (working and menopause)
  12. http://thechart.blogs.cnn.com/2011/09/23/what-the-yuck-signs-of-perimenopause/ (signs of peri-menopause)
  13. http://www.columbiasurgery.org/thyroid/ (menopause and the thyroid)
  14. http://www.healthcanal.com/female-reproductive/26633-CBT-effective-treating-menopause-symptoms.html (cognitive and behavioral)
  15. http://www.thecompounder.com/alternative-treatments/hormone-imbalance/hormone-faq (hysterectomy FAQ’s)

Leave a Comment

More Support: Webinars by Dr. Kruse

  • Hormone Replacement & Finding a Doctor (June 2012) http://www.jackkruse.com/june-2012-webinar/
supplement-DHEA
Life Extension DHEA
Dehydroepiandrosterone
Twist 25 DHEA cream Life Extension Vitamin E
Life Extension
Gamma E Tocopherol
NOW Foods Saw Palmetto Life Extension Boron
supplement-Melatonin supplement-VitaminD3  krill-oil
Life Extension Melatonin
6 Hour Timed Release
Life Extension Vitamin D3 Now Foods Krill Oil
supplement-VitaminK sunfood-brazilnuts
Life Extension Super K with Advanced K2 Complex Sunfood Super Foods
Brazil Nuts
 Dehydroepiandrosterone
(DHEA) and Aging
(Annals of
the New
York
Academy of Sciences)

 

Additional Resources

Cites

  • Dharia S, Parker CR Jr. Adrenal androgens and aging. Semin Reprod Med. 2004 Nov;22(4):361-8
  • Jo H, Park JS, Kim EM, et al. The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2003 Aug;11(8):585-94.
  • Jankowski CM, Gozansky WS, Schwartz RS, et al. Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. J Clin Endocrinol Metab. 2006 Aug;91(8):2986-93.
  • Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004 Nov 10;292(18):2243-8.
  • Alhaj HA, Massey AE, McAllister-Williams RH. Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study. Psychopharmacology (Berl). 2006 Nov;188(4):541-51.
  • Ritsner MS, Gibel A, Ratner Y, Tsinovoy G, Strous RD. Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: a randomized, double-blind, placebo-controlled, crossover trial. J Clin Psychopharmacol. 2006 Oct;26(5):495-9.
  • Schmidt PJ, Daly RC, Bloch M, et al. Dehydroepiandrosterone monotherapy in midlife-onset major and minor depression. Arch Gen Psychiatry. 2005 Feb;62(2):154-62.
  • Fukai S, Akishita M, Yamada S, et al. Association of plasma sex hormone levels with functional decline in elderly men and women. Geriatr Gerontol Int. 2009 Sep;9(3):282-9.
  • Valenti G, Ferrucci L, Lauretani F, et al. Dehydroepiandosterone and cognitive function in the elderly: The InCHIANTI Study. J Endocrinol Invest. 2009 Oct;32(9):766-72.
  • Davis SR, Shah SM, McKenzie DP, Kulkarni J, Davison SL, Bell RJ. Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. J Clin Endocrinol Metab. 2008 Mar;93(3):801-8.
  • Ritsner MS, Strous RD. Neurocognitive deficits in schizophrenia are associated with alterations in blood levels of neurosteroids: A multiple regression analysis of findings from a double-blind, randomized, placebo-controlled, crossover trial with DHEA. J Psychiatr Res. 2010 Jan;44(2):75-80.
  • Bazin MA, El Kihel L, Boulouard M, Bouët V, Rault S. The effects of DHEA, 3beta-hydroxy-5alpha-androstane-6,17-dione, and 7-amino-DHEA analogues on short term and long term memory in the mouse. Steroids. 2009 Nov;74(12):931-7.
  • Chen C, Lang S, Zuo P, Yang N, Wang X. Treatment with dehydroepiandrosterone increases peripheral benzodiazepine receptors of mitochondria from cerebral cortex in D-galactose-induced aged rats. Basic Clin Pharmacol Toxicol. 2008 Dec;103(6):493-501.
  • Taha A, Mishra M, Baquer NZ, Sharma D. Na+ K(+)-ATPase activity in response to exogenous dehydroepiandrosterone administration in aging rat brain. Indian J Exp Biol. 2008 Dec;46(12):852-4.
  • de la Torre JC. Pathophysiology of neuronal energy crisis in Alzheimer’s disease. Neurodegener Dis. 2008;5(3-4):126-32.
  • Camus V. Evaluation of the depressive symptomatology in the elderly. Psychol Neuropsychiatr Vieil. 2004 Sep;2 Suppl 1:S13-17.
  • Djernes JK. Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand. 2006 May;113(5):372-87.
  • Akinola M, Mendes WB. The dark side of creativity: biological vulnerability and negative emotions lead to greater artistic creativity. Pers Soc Psychol Bull. 2008 Dec;34(12):1677-86.
  • Wang HT, Chen SM, Lee SD, et al. The role of DHEA-S in the mood adjustment against negative competition outcome in golfers. J Sports Sci. 2009 Feb 1;27(3):291-7.
  • Strous RD, Maayan R, Lapidus R, et al. Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry. 2003 Feb;60(2):133-41.
  • Herbert J. Neurosteroids, brain damage, and mental illness. Exp Gerontol. 1998 Nov-Dec;33(7-8):713-27.
  • Bloch M, Schmidt PJ, Danaceau MA, Adams LF, Rubinow DR. Dehydroepiandrosterone treatment of midlife dysthymia. Biol Psychiatry. 1999 Jun 15;45(12):1533-41.
  • Strous RD, Maayan R, Kotler M, Weizman A. Hormonal profile effects following dehydroepiandrosterone (DHEA) administration to schizophrenic patients. Clin Neuropharmacol. 2005 Nov-Dec;28(6):265-9.
  • Rabkin JG, McElhiney MC, Rabkin R, McGrath PJ, Ferrando SJ. Placebo-controlled trial of dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS. Am J Psychiatry. 2006 Jan;163(1):59-66.
  • Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH. Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol. 2009 Jan;30(1):65-91.
  • Mo Q, Lu S, Garippa C, Brownstein MJ, Simon NG. Genome-wide analysis of DHEA- and DHT-induced gene expression in mouse hypothalamus and hippocampus. J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):135-43.
  • Pinnock SB, Lazic SE, Wong HT, Wong IH, Herbert J. Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat. Neuroscience. 2009 Feb 18;158(4):1644-51.
  • Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4279-84.
  • Jankowski CM, Gozansky WS, Kittelson JM, Van Pelt RE, Schwartz RS, Kohrt WM. Increases in bone mineral density in response to oral dehydroepiandrosterone replacement in older adults appear to be mediated by serum estrogens. J Clin Endocrinol Metab. 2008 Dec;93(12):4767-73.
  • von Muhlen D, Laughlin GA, Kritz-Silverstein D, Bergstrom J, Bettencourt R. Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial. Osteoporos Int. 2008 May;19(5):699-707.
  • Weiss EP, Shah K, Fontana L, Lambert CP, Holloszy JO, Villareal DT. Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone. Am J Clin Nutr. 2009 May;89(5):1459-67.
  • Buford TW, Willoughby DS. Impact of DHEA(S) and cortisol on immune function in aging: a brief review. Appl Physiol Nutr Metab. 2008 Jun;33(3):429-33.
  • Kim SK, Shin MS, Jung BK, et al. Effect of dehydroepiandrosterone on lipopolysaccharide-induced interleukin-6 production in DH82 cultured canine macrophage cells. J Reprod Immunol. 2006 Jun;70(1-2):71-81.
  • Nawata H, Yanase T, Goto K, Okabe T, Ashida K. Mechanism of action of anti-aging DHEA-S and the replacement of DHEA-S. Mech Ageing Dev. 2002 Apr 30;123(8):1101-6.
  • Frantz MC, Prix NJ, Wichmann MW, et al. Dehydroepiandrosterone restores depressed peripheral blood mononuclear cell function following major abdominal surgery via the estrogen receptors. Crit Care Med. 2005 Aug;33(8):1779-86.
  • Marcu AC, Paccione KE, Barbee RW, et al. Androstenetriol immunomodulation improves survival in a severe trauma hemorrhage shock model. J Trauma. 2007 Sep;63(3):662-9.
  • Oberbeck R, Deckert H, Bangen J, Kobbe P, Schmitz D. Dehydroepiandrosterone: a modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis. Intensive Care Med. 2007 Dec;33(12):2207-13.
  • Burdick NC, Dominguez JA, Welsh TH, Jr., Laurenz JC. Oral administration of dehydroepiandrosterone-sulfate (DHEAS) increases in vitro lymphocyte function and improves in vivo response of pigs to immunization against keyhole limpet hemocyanin (KLH) and ovalbumin. Int Immunopharmacol. 2009 Jul 29.
  • Mills SJ, Ashworth JJ, Gilliver SC, Hardman MJ, Ashcroft GS. The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors. J Invest Dermatol. 2005 Nov;125(5):1053-62.
  • Romanutti C, Bruttomesso AC, Castilla V, Bisceglia JA, Galagovsky LR, Wachsman MB. In vitro antiviral activity of dehydroepiandrosterone and its synthetic derivatives against vesicular stomatitis virus. Vet J. 2009 Nov;182(2):327-35.
  • Acosta EG, Bruttomesso AC, Bisceglia JA, Wachsman MB, Galagovsky LR, Castilla V. Dehydroepiandrosterone, epiandrosterone and synthetic derivatives inhibit Junin virus replication in vitro. Virus Res. 2008 Aug;135(2):203-12.
  • Santos CD, Toldo MP, Santello FH, Filipin Mdel V, Brazão V, do Prado Júnior JC. Dehydroepiandrosterone increases resistance to experimental infection by Trypanosoma cruzi. Vet Parasitol. 2008 May 31;153(3-4):238-43.
  • Brazão V, Santello FH, Caetano LC, Del Vecchio Filipin M, Paula Alonso Toldo M, do Prado JC, Jr. Immunomodulatory effects of zinc and DHEA on the Th-1 immune response in rats infected with Trypanosoma cruzi. Immunobiology. 2009 Jul 4.
  • Caetano LC, Santello FH, Del Vecchio Filipin M, et al. Trypanosoma cruzi: dehydroepiandrosterone (DHEA) and immune response during the chronic phase of the experimental Chagas’ disease. Vet Parasitol. 2009 Jul 7;163(1-2):27-32.
  • Harding G, Mak YT, Evans B, Cheung J, MacDonald D, Hampson G. The effects of dexamethasone and dehydroepiandrosterone (DHEA) on cytokines and receptor expression in a human osteoblastic cell line: potential steroid-sparing role for DHEA. Cytokine. 2006 Oct;36(1-2):57-68.
  • Choi IS, Cui Y, Koh YA, Lee HC, Cho YB, Won YH. Effects of dehydroepiandrosterone on Th2 cytokine production in peripheral blood mononuclear cells from asthmatics. Korean J Intern Med. 2008 Dec;23(4):176-81.
  • Hansen PA, Han DH, Nolte LA, Chen M, Holloszy JO. DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet. Am J Physiol. 1997 Nov;273(5 Pt 2):R1704-1708.
  • Richards RJ, Porter JR, Svec F. Long-term oral administration of dehydroepiandrosterone has different effects on energy intake of young lean and obese male Zucker rats when compared to controls of similar metabolic body size. Diabetes Obes Metab. 1999 Jul;1(4):233-9.
  • Ponholzer A, Madersbacher S, Rauchenwald M, Jungwirth S, Fischer P, Tragl KH. Vascular risk factors and their association to serum androgen levels in a population-based cohort of 75-year-old men over 5 years: results of the VITA study. World J Urol. 2009 Jun 28.
  • Tagliaferro AR, Davis JR, Truchon S, Van Hamont N. Effects of dehydroepiandrosterone acetate on metabolism, body weight and composition of male and female rats. J Nutr. 1986 Oct;116(10):1977-83.
  • Poczatková H, Bogdanová K, Uherková L, et al. Dehydroepiandrosterone effects on the mRNA levels of peroxisome proliferator-activated receptors and their coactivators in human hepatoma HepG2 cells. Gen Physiol Biophys. 2007 Dec;26(4):268-74.
  • Karbowska J, Kochan Z. Effect of DHEA on endocrine functions of adipose tissue, the involvement of PPAR gamma. Biochem Pharmacol. 2005 Jul 15;70(2):249-57.
  • Smith KJ, Skelton HG. Peroxisomal proliferator-activated ligand therapy for HIV lipodystrophy. Clin Exp Dermatol. 2001 Mar;26(2):155-61.
  • Kochan Z, Karbowska J. Dehydroepiandrosterone up-regulates resistin gene expression in white adipose tissue. Mol Cell Endocrinol. 2004 Apr 15;218(1-2):57-64.
  • de Heredia FP, Cerezo D, Zamora S, Garaulet M. Effect of dehydroepiandrosterone on protein and fat digestibility, body protein and muscular composition in high-fat-diet-fed old rats. Br J Nutr. 2007 Mar;97(3):464-70.
  • de Heredia FP, Larque E, Zamora S, Garaulet M. Dehydroepiandrosterone modifies rat fatty acid composition of serum and different adipose tissue depots and lowers serum insulin levels. J Endocrinol. 2009 Apr;201(1):67-74.
  • Yorek MA, Coppey LJ, Gellett JS, et al. Effect of treatment of diabetic rats with dehydroepiandrosterone on vascular and neural function. Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1067-1075.
  • Sato K, Iemitsu M, Aizawa K, Ajisaka R. DHEA improves impaired activation of Akt and PKC zeta/lambda-GLUT4 pathway in skeletal muscle and improves hyperglycaemia in streptozotocin-induced diabetes rats. Acta Physiol (Oxf). 2009 Nov;197(3):217-25.
  • Brignardello E, Runzo C, Aragno M, et al. Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type 2 diabetic patients. Diabetes Care. 2007 Nov;30(11):2922-7.
  • Ponikowska B, Jankowska EA, Maj J, et al. Gonadal and adrenal androgen deficiencies as independent predictors of increased cardiovascular mortality in men with type II diabetes mellitus and stable coronary artery disease. Int J Cardiol. 2009 Apr 21.
  • Cappola AR, O’Meara ES, Guo W, Bartz TM, Fried LP, Newman AB. Trajectories of dehydroepiandrosterone sulfate predict mortality in older adults: the cardiovascular health study. J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1268-74.
  • Srinivasan M, Irving BA, Dhatariya K, et al. Effect of dehydroepiandrosterone replacement on lipoprotein profile in hypoadrenal women. J Clin Endocrinol Metab. 2009 Mar;94(3):761-4.
  • Ii M, Hoshiga M, Negoro N, et al. Adrenal androgen dehydroepiandrosterone sulfate inhibits vascular remodeling following arterial injury. Atherosclerosis. 2009 Sep;206(1):77-85.
  • Aragno M, Meineri G, Vercellinatto I, et al. Cardiac impairment in rabbits fed a high-fat diet is counteracted by dehydroepiandrosterone supplementation. Life Sci. 2009 Jul 3;85(1-2):77-84.
  • Mitchell GF. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol. 2008 Nov;105(5):1652-60.
  • Stomati M, Monteleone P, Casarosa E, et al. Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause. Gynecol Endocrinol. 2000 Oct;14(5):342-63.
  • Brooke AM, Kalingag LA, Miraki-Moud F, et al. Dehydroepiandrosterone improves psychological well-being in male and female hypopituitary patients on maintenance growth hormone replacement. J Clin Endocrinol Metab. 2006 Oct;91(10):3773-9.
  • Nordmark G, Bengtsson C, Larsson A, Karlsson FA, Sturfelt G, Rönnblom L. Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus. Autoimmunity. 2005 Nov;38(7):531-40.
  • Hackbert L, Heiman JR. Acute dehydroepiandrosterone (DHEA) effects on sexual arousal in postmenopausal women. J Womens Health Gend Based Med. 2002 Mar;11(2):155-62.
  • Lee SY, Myung SC, Lee MY, et al. The effects of dehydroepiandrosterone (DHEA)/DHEA-sulfate (DHEAS) on the contraction responses of the clitoral cavernous smooth muscle from female rabbits. J Sex Med. 2009 Oct;6(10):2653-60.
  • Lee KS, Oh KY, Kim BC. Effects of dehydroepiandrosterone on collagen and collagenase gene expression by skin fibroblasts in culture. J Dermatol Sci. 2000 Jun;23(2):103-10.
  • Calvo E, Luu-The V, Morissette J, et al. Pangenomic changes induced by DHEA in the skin of postmenopausal women. J Steroid Biochem Mol Biol. 2008 Dec;112(4-5):186-93.
  • Bloch M, Schmidt PJ, Danaceau MA, Adams LF, Rubinow DR. Dehydroepiandrosterone treatment of midlife dysthymia. Biological Psychiatry. 1999 Jun 15;45(12):1533-41
  • http://www.futurescience.com/dhea.html

Comments

  1. Jens Pohl says:

    Thorough stuff — thanx for the webinar!!!

  2. ATL_Paleo says:

    Great webinar today … really enjoyed it. Lots of very actionable ideas provided. Highly recommend it to anybody who wants to be optimal.

  3. Patty Cakes says:

    Thanks! The webinar was great and the followup blog was perfect! I learned a lot and both were helpful since I have been on the hormonal roller coaster trying to balance them out for about 8 years. You gave us some good guidelines to follow.

    One question I am a bit confused on is the SHBG. My labs showed elevated SHBG and in my research I haven’t found info on what causes this is women. I can’t figure out what needs to be done to get this lowered. Any ideas?

  4. Kathy Crowe says:

    My head is still spinning from all the great info from the webinar. Any way to listen again or get a transcript?

  5. Souldanzer says:

    Looks like there’s a few reasons why I’ve been in love with my bottle of DHEA ever since I got a hold of it. I think I over did the DHEA for a while though and it sent my sleep to super crappy? Is that possible? It got better again once I dropped the dose.

  6. @patty those are all the things we do in educational consults.

  7. @Atl Thanks…..it was fun to do…….

  8. @Soul I thought you might like this one……..lots of gold in the webinar today.

  9. Gracelind says:

    With a B-cell mediated autoimmune disease such as Sjogren’s Syndrome is it wise to increase B-cell levels in the body with DHEA? One of the treatments being explored for SjS is Rituxan, which destroys mature B-cells in the body and can suppress levels for months to years.

    My own muscle biopsy showed T-cells and B-cells attacking otherwise healthy-appearing muscle fibers leading to Dx of inflammatory myopathy in addition to SjS.

    If DHEA supplementation merely increases the number of B and T cells, that seems counter-productive since treatment is use of immunosuppressants. But if DHEA could produce immune cells that distinguish between self- and non-self tissues and don’t participate in AI attack then an AI person could realize all the other benefits.

    Current use of heavy duty immunosuppressants in AI doesn’t cure the disease and can’t be targeted to affect just the defective immune cells.

    Personal note: I have begun the AI protocols of Wolf, Cordain, and the other Paleo-types. DHEA level on last test a year ago was low normal range. I’m female, age 60.

    Any thoughts on this dilemma most appreciated.

    • @Gracelind These were issues we tackled in the webinar…….i’d suggest you listen to it. I believe it was over 1.5 hours and had a lot of data. If you go one the forum they might give you some feedback. I am doing lots of consults this afternoon.

      AI are all epigenetic diseases. Hormones are how the epigenetic information is relayed to the ten trillion cells in our body. The brain is not connected to every cell via a nerve. Going paleo means a lot of different things to different people……my version of it is different than most and most people who begin do not come to paleo at the same biologic point of illness or health……hence the reason why blanket approaches fail. Because we are so sensitive to epigenetics you need to understand how to affect your personal epigenetics best for you by becoming your own inner guru……its easy to do when you test and see where you are at int he continuum of health and illness.

  10. Glamazon says:

    Exciting stuff!

  11. SeaHorse says:

    Great and useful webinar…I particularly like the info. that I can bring to my husband about optimizing his health through the hormone testing…it hits closer to home in a way that some other elements haven’t (low light, CT etc.) and I think will make an impact.

    • @SeaHorse……yes husbands I am sure will get hassled after this but it could be good. If they listen to the replay they may get shocked at some of the numbers and what they are tied to.

  12. Very good webinar. Thanks so much for your vast knowledge on all things optimal. My doc recently upped my DHEA from 25mg to 50mg. I’m not quite sure if it should have been this high a jump. Even though I have no markers or history or family history of breast cancer I have extremely tender breasts and have had acne breakout since this jump. I’ve also had an increase in amounts of progesterone and estrogen prescribed. My PG:E2 ratio isn’t ideal and he has me on testosterone so I’m not sure where to begin when I question him. Any suggestions?

    • @Sherry then maybe ask your doc to check your PG/E2 ratio…..i bet that is the real culprit as the DHEA has risen. You could also change over to the 7 keto version. Talk to the doc.

  13. Patty Cakes says:

    Thanks Dr. K. Just got my 23andme test in and need updated hormonal labs then the consult. I can hardly wait!

  14. Terry F says:

    Very helpful seminar. I got my labs done Friday. She had a string of labels at least 2.5 feet long. So thanks for the suggestion to go to LEF. i got the list from them. I will order the HSCRP from them too and make my appointment with you. I didn’t hear much about pregnenelone. I started 3 month ago to take both preg and DHEA. There was not much movement in either. so I stopped the preg and increased the DHEA which is now up to 400. So now I’ve added back in the preg and lowered the dose of DHEA a bit. Any comments about the combo will be helpful. Thanks.

    • @Terry It will be interesting to see where you fall on the labs for sure. I cant really comment about the rest on the internet.

  15. Thank you for discussing this health aspect.

    Normal Ideal:
    Men 280-640 μ/dL 500-640 μ/dL
    Women 65-380 μ/dL 250-380 μ/dL
    —————–
    I am 72yo men

    Using 200mg/day 7ketoDHEA and 300mg/day DHEA
    I got DHEAs=670.8 μ/dL
    feel ok, no obvious side effects, but bothered by bad/very high
    (5x over top range) number for 5α-Androstane-3α (DHT was at the top of range)

    reduced to 200mg/day 7ketoDHEA and 200mg/day DHEA (half taken at wakeup, then 4hrs latter)
    that kept my 5α-Androstane-3α at good level
    but now DHT=59(75-85)ng/dL——>reduced ## of orgasms/week (Oxytocin suffers)
    ——————
    For years I have seen recommendation for men 500-640 μ/dL at lef.org (do not remember what was suggested for women)
    then, recently they changed to
    men 350-490 μg/dL
    Women 275-400 μg/dL
    ——————

    5aR and 5bR are underdiscussed,
    specially when one starts supplementing with DHEA
    how this affects downstream metabolites and what it does to health.

    .

  16. jackkruse.com/2-for-1-july-4th-special/

  17. Patty Cakes says:

    Thanks! But I cannot get the link to work for the special consultation. It takes me to a PayPal page that states “Sorry — your last action could not be completed”. I’ll keep trying. Not sure if anyone else is having issues.

  18. Irene Pahlsson says:

    If we buy a consult (1 hr), would the free one have to be during your open times this week, i.e.

    all day Sunday (July 1st)
    Monday 2 pm to 7 pm (July 2nd)
    Tuesday noon to 7 pm (July 3rd)
    Wednesday 6 am to noon (July 4th),

    or could it be later on in July or Aug??

    • @Irene if you buy the one hour consult this week your other hour can be scheduled down the road with me via my email once you get a new set of labs or something new develops that you want to talk about. It’s your choice.

  19. nancy deily says:

    Same for me! I just tried to sign up for consult but it would not let me.

    • @nancy read the answer to Elin……..pick the July 1-4 times and I will honor it as long as you go the regular consult booking routine on the website page in the member tab

  20. Elin Duke Potter says:

    Dr. Kruse – 2 questions:

    1- At one point during the webinar, you mentioned a website we should visit if we wanted a “happy vagina.” I must’ve copied it down incorrectly. Would you please give it again?

    2- re July 4th special: I don’t skype. Do you do plain phone or email consults?

    Elin

    • @Elin I will do the phone consults too……you can sign up the regular way and tell me it is for the special days via the sign in……I will know when you book on the days prescribed in the special.

      It is inner intimates.com

  21. nancy deily says:

    thanks jack. i did go onto the adjusted link and paid via pay pal and then listed several choices for times. so i am hoping they were successfully entered. at this point i have no way of knowing as the site does not tell me.
    also i have had trouble recently when trying to log in general and am waiting for a reply from MM re same.

  22. Colleen Coble says:

    Great information today on the webinar, Doc. 🙂 Very interesting about not supplementing with testosterone until the progesterone and estrogen are balanced!

    I have to say though that without the PSA test, my husband would be full of cancer right now. It was only the PSA that told us there was something wrong. His digital exam the year before was fine. Even when we went in for the check after the high PSA, his digital exam was fine, the prostate felt perfect. But the biopsy was a different story and there was cancer in all 4 quadrants. When he had the prostate removed, it had moved so fast that it had escaped the prostate by then and was in the seminal vesicles. So the digital really doesn’t tell us a thing. The most dangerous cancers that are fast moving don’t show up on it.

    I also think women should get a CA-125 even though it also isn’t specific for ovarian cancer. When it’s elevated there is something wrong. When the PSA is elevated there is something wrong. It might not always be cancer, just as an elevated CA-125 might not be ovarian cancer but it makes the doctor take a closer look. I’m SO thankful for the PSA because I still have my Dave.

    Do you recommend regular DHEA if a woman has no history of breast cancer? Regular DHEA has raised my testosterone levels and I don’t have to take testosterone itself now. Or do you think it’s better to take 7-Keto and add the testosterone separately?

    • @Colleen the issue to use regular DHEA of Keto in that case depends upon the doctor and the patients discussions about the particulars on their case. I made that clear in the Webinar. I understand the issue about your hubby but the American Urologic Society has changed their stance on PSA screenings as you well know now. Too many men where getting biopsied too often and the risk benefit ratio was not worth the risks in their studies. Obviously I think it is a point you would discuss with the doctor during the course of events as your husband did.

  23. @JanSz post #19
    @Jack Says: post #23
    JanSz you said you were on arimidex too, or are you using natural aromatase blockers?
    ——-
    The idea is to lower E2 if high, and keep it at desired level.
    That can be achieved by inhibiting production of E2 by inhibiting aromatase with Arimidex
    I use 1mg/E5D
    And/or faster metabolism or modification of 2:16 OHE1 Ratio, zinc, DIM, I3C, cruciferous vegetables, rosemary, turmeric, cimetidine, thyroid and omega3 management
    I use zinc-100mg/day, 2grains Thyroid-S, brocoli, saurcraut, and a whole project on O6/O3 started by you sending me to dr Patricia Kane
    We are not done working on intricacies of Krill Oil.

    .

  24. Elin Duke Potter says:

    Thanks. I *did* get it right. The web site is down. Inner Intimates is now located at http://www.olgassecret.com/

  25. Organic coconut oil is the best sexual lubricate I have found. It’s cheap, safe and effective. Most people on this forum will already have it in their kitchen.

  26. It is good, Caroline!

  27. Dennis Walla says:

    Great article Doc.

    This really explained my lab results from June 5 and the consequences of supplementing DHEA. I could not figure out why IGF-1 increased and IL-6 was so low even though I still have a chronic sleep disorder. But I did not get good results with DHEA til I added some pregenolone into the mix.

    After listening to your early podcasts, I thought the increased IGF-1 and low IL-6 was due to CT therapy. Any ideas about reconciling the two?

    Strange that you should also mention Lp(a). It is high on my VAP test and my research has indicated that it is a genetic problem that can’t be fixed with lifetstyle or drugs. Maybe when I do a VAP again later this year it will be reduced with the DHEA.

    Working on the theory that high Lp(a)”blocks leptin to enter the hypothalamus” (how does leptin Rx work blog)
    thus causing sleep disorder.

    Have a good 4th Doc, sounds like your gonna be busy!

  28. Elin Duke Potter says:

    @Dr K – Got the shirt. It rocks! Did you get my consultation request?

    • @Elin Did you book it…..I’ve been slammed today with consults…….did not even eat I have been so busy.

  29. Gretchen says:

    Thanks for both the Webinar and this follow up blog.

    DHEA and IL-6, for me this is a BIG WOW! I’m guessing that if IL-6 is one of the factors driving my inflammation (testing will verify), the 7Keto and the DHEA I’ve been taking has helped with starting the reversal process.

    so If IL-6 is causing inflammation, to include a sub-optimal brain-gut relationship, DHEA is one way to address this, however if you’re a women, in order to eliminate the IL-6 problem you also need a Pg/E2 ratio in the top quartile of the range (100-500) for the Pg/E2 ratio correct? Other wise you keep chasing your tail – and you’ll never fix the IL-6 problem with the DHEA

    Is there a different way to address this for men, if their IL-6 is causing inflammation? or is DHEA supplementation, after consult w/your PCP based upon labs sufficient?

    For those of us who have PCOS, we’ve got to fix the Pg/E2 first, then we start working on DHEA next correct? Once we’ve fixed the Pg/E2 ratios, and brought the DHEA – any inflammation related to IL-6, assuming that’s the source, should disappear? From their we then can address Testosterone, assuming it is required.

    For those women who are “Testosterone makers” – Based upon both the webinar, and the blog above, Which is better for them, based upon labs? 7KetoDHEA, or DHEA?

    I asked this on the Webinar – but thought it was a good question to ask here so others reading the blog can see the answer as well.

    How does low Testosterone, and other hormones, such as DHEA, impact Alzheimer’s disease?

    How do the different hormone levels of T, Pg, E2, & DHEA in men/women impact Alzheimer’s disease? Can just one being low, impact your probability of getting it, or do you need the “perfect storm” of Low hormone “X”, and a diet of grains, legumes, and dairy to turn on the epigenetic switches that cause this disease?

    Thanks for the great blog and webinar?

  30. andy smith says:

    My DHEA-S levels were <100 for years (while in my early 20's) and my Endo never recommended supplementation. Makes me wonder why he tested for it in the first place!

    FYI, the LEF brand DHEA has rice flour in it.

  31. Gretchen says:

    So, Jack. I’ve been reading up on Low T3 – and it all comes back to IL-6! WOW! I feel like I’ve been standing to close to George Seurat’s paining “A Sunday Afternoon on the Island of Grand Jatte” at the art institute in Chicago. I’ve finally stepped far enough back and I can see what’s going on!

    Thanks for taking the blinders off!

  32. what is the difference between the prescription DHEA and the DHEA available at the local health food store?

  33. kathylu says:

    Just wanted to mention that DHEA was the reason I was able to get pregnant at 47. I worked with a reproductive endocrinologist who put me on 300 mg of DHEA per day to encourage oocyte maturation. It worked…and by the way, I had almost no side effects, just a little nervousness and mild acne. I also used acupuncture to balance my hormones. That seemed to be helpful as well. Just sayin’.

    • @Kathylu I have seen this used as well for this……but since it is outside the standard of care we must be careful of what we talk about.

  34. @kathylu
    I worked with a reproductive endocrinologist who put me on 300 mg of DHEA per day to encourage oocyte maturation.
    ——————-
    Do you happen to know your (DHEAs,serum) level, while on 300mg/day DHEA

    It took me (men) 200mg/day-7ketoDHEA and 300mg/day-DHEA to move my DHEAs, serum to the right level.

    .

  35. Elin Duke Potter says:

    @Dr. K – Booked for 07/04 @ 0800.

  36. are there any more time slots? what if I buy 1 & there are none left?

  37. kathylu says:

    Sorry Dr. K. I wasn’t suggesting that anyone try this, just recounting my personal experience. I certainly wouldn’t have done it without the guidance of a knowlegable physician. Please feel free to delete my comments if needed.

  38. I booked a time on 7-4. didn’t print the disclaimer. don’t no how2 find the disclaimer online again. Where doI go 4 that?

  39. Dr. Jack…great webinar! You mentioned you made your own DHEA cream. Will you share your recipe or anyone else have one or can you buy it or do you have it compounded?

    Do you make it with either DHEA or 7 Keto depending on your own situation?

  40. KIM COOK says:

    Hi Dr Kruse!!

    Not new to the website but new to commenting.
    What does it mean if your DHEA is high? Mine is 447.2
    (lab limits 35.4-256.0). Anything to worry about?

    Thanks for all your information and insight!!

  41. KIM COOK Says:
    What does it mean if your DHEA is high? Mine is 447.2
    (lab limits 35.4-256.0). Anything to worry about?
    ——————————————————————
    Range (35.4-256.0) indicates that you are actually tested DHEAs,
    likely at LabCorp
    and that you are woman (45-54) yo
    ——————————————————————
    Seeking benchmark of good health it is good to look at
    20-24 yo woman, they statistically have a range (148.0-407.0)(μg/dL)
    When supplementing with DHEA, lef.org (mostly dr Dzugan) recomends
    (Women (275-400) μg/dL)
    ——————————————————————
    If you got here by supplementing, reduce dose.
    If you got there naturally, or want to study this health area,
    do 24 hr urine analysis
    http://www.musclechatroom.com/forum/showthread.php?4433-DHT-gt-3a-3%26%23945%3B-Androstanediol-Glucuronide-(3%26%23945%3B-diol-G)&p=175901#post175901

    ……. I am not a doctor.

    • @Jansz and Kim Cook Jan gives great advice here. Part of flourishing is allowing others to learn about their health processes under our watchful eye. No one creates health for you. We shine light on wellness for you…..at least that is how it should work.

  42. @Jack Says:
    @Jansz and Kim Cook Jan gives great advice here.
    ————————————–
    dr Jack,
    thank you.
    I could use explanations on how to manage,
    aromatase, 5aR, 5bR and hormones that they are affecting, in a way that would be helpful, but avoid common pitfalls.
    There seem to be growing population of people that are permanently hurt by finasteride and duosteride, (Proscar, Avodart) also Acutane

    .

    • @Jansz I don’t like finasteride/duosteride period (recent studies in the Journal of Sexual medicine dont either)……it kills the male HPA. Management cant be discussed openly on the internet because that would be practicing medicine on th enet which we can not do.

  43. melrito says:

    it’s better to get nutrients from food, but what if someone is taking supplements such as dhea and cruciferous veggies are recommended with that. In winter, these do not grow, so my question is would it be optimal to supplement with a cruciferous vegetable extract in winter, or does that also create an inconsistency for the body since the extract comes from veggies that do not grow in winter?

    • @Melrito in winter DHEA and the sex steroid hormones are supported by the cold……re read CT 6. When the foods are not their normally due to seasons the temperature off sets it.

  44. @Jack Says

    @Jansz I don’t like finasteride/duosteride period (recent studies in the Journal of Sexual medicine dont either)……it kills the male HPA. Management cant be discussed openly on the internet because that would be practicing medicine on th enet which we can not do.
    ——————-
    I am not after practicing medicine over internet.
    I am after education, there is plenty of it around and you are also educating this way already.
    How to manage,
    aromatase, 5aR, 5bR and hormones that they are affecting,
    is rather general topic.

    It is already being discussed in number of places, except the area of interest is for gravely ill people on a way out. I would be interested in this application but in people who are currently falling into limbo and are pronounced perfectly healthy, when they are far from it.

    .

    • @Jansz I love the use of them….I talked about them in my webinar and in many of my education consults. So far though I have not felt comfortable discussing them here.

  45. Ok, something else.
    Comparing Ed/dr Patricia Kane article
    and
    Essential & Metabolic Fatty Acids Analysis (EMFA) by Genova Diagnostics
    I can see room for improvement in Genova’s test.
    It would help to walk step by step thru this test and make some adjustments.

    Otherwise it is rather good test.

    ..

  46. Caroline Cooper says:

    Does anyone know what the ingredients of the Vaginal Renewal Complex from olgassecret.com? They state there are four oils: evening primrose, shea oil, vitamin E and vitamin D. What are the other two oils used in the products?

  47. Can you please give the recipe for your stretch mark cream, unless I missed it somewhere. If they are white, does that mean they are too far gone?

  48. How long after starting to supplement with DHEA should one follow up with testing? And just to be clear, you’re saying we do not need to stop supplementing prior to testing? Thanks!

  49. Meghan Miller says:

    If you don’t have any risk factors, in general would you recommend regular dhea over 7-keto dhea? And without leaky gut, which is more optimal, topical or oral?

  50. Meghan Miller says:

    What brand of SL do you use? Also for stretch marks, would a regular topical dhea at 15mg/pump do or does it have to be a specially formulated at a lower/higher strength? what strength does your wife use?

  51. Chad Yarbrough says:

    Jack, what’s your take on DHEA’s effect on the HPA axis?

    • @Chad depends upon the amount of inflammation present. If your inflamed no amount of DHEA will help you longer term. It will help sleep short term. Right now I have seen no articles that have convinced me that oral DHEA can really alter the HPA axis directly……..i think it might by the feedback loops indirectly.

  52. Meghan Miller says:
  53. Thank you for the excellent post. I do appreciate the detail that is characteristic in your articles. It’s very helpful to those of us who don’t want to infer and guess. Thank you so much!

    I am having trouble comprehending this one sentence. I apologize if I am being dense. It happens sometimes. Would you mind clarifying this statement, please?

    ” In women, DHEA replacement topically decrease TNF alpha in the skin to destroy inflammation locally. If you ever meet my wife, you will see the affect. She does not look her age at all.”

    The part that’s troublesome to me is “DHEA replacement topically decrease TNF alpha…” I just can’t make sense of that clause.

    • Kim TNF alpha is part of the inflammatory response………too much of it leads to changes in the optical signaling in skin. To read about those photoelectric effects read the Time 8 blog…….it gets to the heart of the issue. Low D3 and DHEA walk hand and hand because of this issue.

Trackbacks

  1. […] samples of pregnant women. They are associated with inflammation, elevate cytokines and lowering or DHEA and progesterone further.  This also allows high cortisol to develop quickly.  Remember what I […]

  2. […] of our intestinal brush border to inflammation that destroys signaling.  We covered that in the DHEA blog.  This is how I  measure of uncoupling of sleep from normal metabolism. I base every case I […]

Speak Your Mind

*

Time limit is exhausted. Please reload CAPTCHA.

Please Note: The author of this site is not engaged in rendering professional advice or services to the individual reader. The ideas, procedures, and suggestions contained within this work are not intended as a substitute for consulting with your physician. All matters regarding your health require medical supervision. I shall not be liable or responsible for any loss or damage allegedly arising from any information or suggestions within this blog. You, as a reader of this website, are totally and completely responsible for your own health and healthcare.