BRAIN GUT 10: The Other Trip through the Rabbit Hole:

My name is Danielle Thatcher and here is my story of the rabbit hole I fell into with MJ when we met Dr. Kruse on his vacation:   When I first sat down to write about my experience with meeting Dr. K, I had the highest of hopes of writing something that would and could inspire many. But when I did sit down to write…. I had nothing.  Literally, nothing. My mind was blank.  I take that back, I have the notes that Dr. Kruse so willingly wrote down for me and the notes that MJ took as well.  But I spent an entire day with this great man, and my mind is blank. Pretty scary for a 45 year old woman!   Before I forget, this is only one of the supplements Dr. Kruse asked me to consider with my doctor for me. Pregnenolone.   If you have insufficient levels of pregnenolone, you can have memory loss, sleep disorders, depression, fatigue, symptoms that mimic Alzheimer’s and other debilitating conditions. I am experiencing many of these symptoms, so I am sure to take my supplements and just waiting for everything to “click” and this machine to start functioning again properly.   The good news […]

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Brain Gut 9: What Really Killed Michael Jackson

Today, we are going to dive into the gut flora story a bit deeper than we did in our first gut flora post to help you understand how a a change in gut flora might lead to changes in your health by altering your hormone panel. Obesity is an inflammatory brain condition. Where does the infection come from? The gut flora actually is what causes humans to become fat. It has to due with shear numbers and the species of bacteria in our gut. There is a particular flora that produces adiposity and obesity in humans. These bacteria make something called FIAF (Fasting induced adipose factor) that control this process. This factor blocks lipoprotein lipase (LPL) in fat cells. LPL allows us to convert dietary Free Fatty Acids carried in lipoproteins into neutral fats that are stored in adipocytes.

Non Geeks: Our gut bacteria makes humans fat.

Geek Alert: The FIAF is made by our liver, muscles, and our small bowel wall when food sources are in short supply. This is the signal to stop storing fat in our fat cells when food is scarce. What is not well appreciated by many is that the FIAF in our intestinal wall is controlled 100% by our gut flora. When we have a simplified gut flora it favors fat cell creation. When our gut flora is complex and healthy, it has 100 trillion cells with 250 species. We tend not to make fat in this instance either! Moreover, when the bacteria are active metabolically due to the presence of simple sugars, production of FIAF ceases, and fat creation is signaled. This implies that our gut flora is directly tied to fat creation in humans. The gut flora’s action is directly signaled to the brain via the afferent nerve fibers in the vagus nerve. In those newly created fat cells, a protein called leptin is also produced, and acts as a score keeper for the brain of how much fat is stored in the body. This messenger is sent to the brain around midnight when we are sleeping allowing the brain to assess total energy balance in the body.

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Brain Gut 8: Their Trip Down the Rabbit Hole

READERS SUMMARY: 1.  What is a day in the life of a vacationing doctor like? 2. Accept that your epigenome is a loaded gun, and your lifestyle is the trigger. Your lifestyle can’t change you. It reveals who you really are. 3.  Is there an important difference between giving up on somethings and letting go to get to Optimal? 4.  You are not your brain. Most of your thoughts and beliefs were given to you by society. 5. When we don’t know who we are, we are prone to be who somebody else wants us to be.  We can change that.     Today we have a guest blog post from MJ Friedman, one of two of our community members who decided to come down south and get a first hand view of what Optimal is really all about.  The other person is Danielle Thatcher.  The following blog are MJ’s words about her 24 hours with me while I was on vacation.  I needed a break and decided to take time off and not go to Boston to be at AHS 2012.  It turns out work seems to follow me no matter where I go now.   Here is Mrs. Friedman’s day……….. […]

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Many of you know I believe obesity if an inflammatory disease of the brain. Where this disease begins may surprise some of you. It begins in our gut flora. How does this happen? Read this link! Sub optimal bacteria which contain bacterial toxins called lipopolysaccharides (LPS) which are found in bacterial cell membranes. As gut LPS rises, it has been shown to cause a rise in serum leptin levels. Once leptin levels are raised high enough it stimulates SOCS 3 signaling in the hypothalamus to cause LR.

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Brain Gut 5: Paradigm Drifts Paradigm Shifts–Epi-Paleo

Geeks: The implications of Brain Gut 4 mean that to develop a brain seafood is required part of the program to maintain it. Nutrients and many other environmental factors have also been found to influence epigenetic programing of our DNA either directly or indirectly via metabolic sensors. Peroxisomal proliferator-activated receptors (PPAR’s), the vitamin D receptors, and the retinoid X receptors (RXR), and the retinoic acid receptors (RAR) are all examples of the nuclear receptors that interact with the brain cell membranes to control inflammation and metabolism all over our bodies. It turns out that PPAR’s are the receptors that are at the crossroads of where inflammation and metabolism actually cross. These are specialized lipid sensors that pay attention to our balance of omega 6 and 3 levels. 3% of the human genome is directly or indirectly controlled by the endocrine functions of the Vitamin D system. This shows you how environmental signals are intertwined into the expression of DNA in humans. The Epi-Paleo Rx controls inflammation at a hormonal level in the brain better than the more famous paleo diet.

Non Geeks: What we eat is really damn important when you have 3 lbs of lipid in your head called a brain. If you eat outside our design you get sick.

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Brain Gut 3: Look In The Past To See Your Prologue

READERS SUMMARY:   1. WHAT ARE THE EVOLUTIONARY IMPLICATIONS OF A LEAKY GUT AS A POSITIVE ADAPTATION AT OUR SPECIES ORIGIN? 2. WHY DID BIPEDALISM ARISE BEFORE BRAINS IN HUMANS? 3. DID THE CLIMATE AND TECTONIC PLATES DICTATE THE EPIGENETIC CHANGES IN THOSE TRANSITIONAL PRIMATES? 4. DID RAPID CHANGES IN INNATE AND CELL MEDIATED IMMUNITY OCCUR BEFORE THE BODY PLAN CHANGES IN PRIMATES? When our ancestor primates acquired this leaky gut mentioned in the last blog Brain Gut 2, it allowed them to assimilate a lot of new genetic material that would help them navigate their new surroundings. This genetic material was assimilated very quickly and in a short amount of time. Why do I say this? In the East African Rift during ‘homo’ speciation their was massive climate change. In times of environmental change species are subjected to something called punctuated equilibrium. This theory states for most of evolutionary time species are in an equilibrium with their environment and then something sudden happens to force adaptation. We saw this in the K-T event, the Young Dryas, and when primates evolved to humans during the late Pilocene. It appears that by studying the difference between primates and human DNA we […]

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Hormone CPC #1: DHEA

This blog post was created for my members who just heard my webinar on bioidentical and synthetic hormone replacement. It is specifically designed to further our discussions in that talk.

DHEA has been an enigma to the public and to most physicians. I never once heard about this hormone in four years of medical school, seven years of residency or in any endocrinology lecture from my training. The general public did not learn about DHEA until 1996, when its benefits were mentioned in the media and several popular books that showed up on daytime TV shows. Most in mainstream medicine continued to ignore the science these books contained because they were not found in the usual ways via journals and continuing education classes. You actually had to be on the lookout for this information. With a busy medical practice, this is no easy task. DHEA became credible to the medical establishment when the New York Academy of Sciences published a book called DHEA and Aging. That book provided scientific validation for the many life-extending effects of DHEA.

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Brain Gut 2: Viral Marketing

READERS SUMMARY: 1. To discover the unknown we must use the known to guide our thoughts to see the future. 2.  How should we think about evolution and health now?  Counterintuitive is an axiomatic cognitive ability  required for neurosurgical residency training and that is why I chose to tackle this problem in this fashion. 3.  If we want to explore the mystery of our clade we need to go back to the things that separate us from them that we know to be true today.  The knowns are that our EQ (encephalization quotient) exploded rapidly.  WHY? 4.  Is our past really our new prologue?   Todays blog is to show you how Factor X was made actionable in bring man from ape.  Most of you know, I believe it was due to a faster epigenetic plan that altered the mammalian body plan.  What most do not know it was the result of viral marketing.  This is not the viral marketing of today’s social media platform.  This is where viral marketing was truly invented.  First created in our oceans,  and eventually incorporated into the DNA of life.  Do you think this hyperbole?  One drop of sea water has a million bacteria […]

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Brain Gut 1: Who Are We, Really?

READERS SUMMARY: 1. WHY CAN’T FOSSILS, BIOCHEMISTRY, TEETH, GEOLOGY, PALEOANTHROPOLOGY TELL US WHERE WE CAME FROM? 2. ARE WE REALLY PILOCENE OR PALEOLITHIC BEINGS? 3. DO WE STRADDLE THE FENCE OF BOTH ERA’S OR IS ONE MORE IMPORTANT? 4. HOW MIGHT NEUROSURGERY GIVE A NEW PERSPECTIVE TO THESE MYSTERIES? 5. IS HOMO HERE BECAUSE OF VIRAL MARKETING?   If you are paleoanthropologist or archeologist you think fossils are the Rosetta Stone for discovering the path that human evolution took. If you are proteomic evolutionary biochemist you think molecular arrays are the best way to decipher the tea leaves of Mother Nature ways. If you are a geneticist you think the RNA/DNA is Holy Grail of human evolution. If you are dental specialist, like University of Arkansas professor, Dr. Peter Ungar you think it’s all about the mammalian teeth. Today’s blogosphere likes to define evolutionary thinking by thinking about the Paleolithic epoch and how it might have shaped the hominid tree. The paleolithic shaped the tree to be sure, but had nothing to do with planting the acorn. The paleolithic diet has been championed best, in my view, by Dr. Loren Cordain’s sustained efforts over the last 30 years. His work […]

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READERS SUMMARY: HOW CAN A LEAKY GUT CAUSE ADRENAL FATIGUE? CAN OTHER THINGS COMPLICATE THIS LIKE A VIRAL INFECTION? CAN WE TREAT IT? HOW DO WE TREAT IT? CAN YOU HOPE FOR IMPROVEMENT TOO? A PATIENT TESTIMONIAL AFTER JUST 4 MONTHS OF TREATMENT We have talked at length on my forum about how a leaky gut can cause havoc for modern humans. What many people do not realize is that humans having a leaky gut happened by design. Primates, our nearest relatives, do not have leaky guts by design because they do not have zonulin the protein that binds our gut cell membranes where they join. Many people are shocked to find out that this make it impossible for a Primate to get an autoimmune disease. This is also true. Primates also can’t get an infection of H. Pylori in their guts either. This is why Barry Marshall had to drink a vat of H. Pylori to prove it caused human ulcer disease in the last part of the 20th century. He had no animal models that would prove his hypothesis. Check out this detailed history of precisely what the establishment did to Dr. Marshall and his ideas for close […]

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Cold Thermogenesis 6: The Ancient Pathway

The best way to describe this pathway to the lay public is to explain this is how evolution allows for ideal form to meet function in a tough environment. This environment is likely the primordial environment for life on our planet. This makes astrophysicists excited, because life might also be evolving in places like Titan. After all 5 extinction events on this planet geologist have told us they were followed by an extended cold climate. In cold mammals live longer. You will find out more about why this happens in Energy and Epigenetics 4 and 5 blog posts.

The pathway uses very little energy from ATP and gives a whole lot to the organism who uses it. Fat burning is required and it is tied to a biochemical pathway that paleo forgot to speak about. But it requires cold temperature to be present and used commonly. In the pathway, the less effort you give, the faster and more powerful you will be when this pathway is active. People who live in this pathway can run a marathon with no training. They can lift unreal amounts of weight with little training. Their reserve and recovery are just incredible. You have to see it to believe it. Many will say cold thermogenesis a hormetic process, when in reality it is created using a coherent energy source due to something called the Hall effect. When we have had extinction events on Earth before, the events usually affect the evaporation of water in some fashion from the surface of lakes and oceans. It also affects the transpiration from the forest trees, plants, and flowers and this change cools the air. You must understand how climatology works here; liquid water needs to absorb a lot of latent heat to in order to evaporate, so it sucks energy from the atmosphere to make this energy transfer. This loss of energy from the atmosphere directly cools the planet and this preserves the charge on life’s inner mitochondrial membrane and in the nanotubes present in our cells that contain water. This is how life lives long in the cold.

Those people don’t realize this because they do not live in this pathway for the majority of their life, and few studies have been done to say otherwise. The link above is recently added to this blog post. It seems science is now proving me correct in my theories of extinction events.

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Hey Lyme Disease, Meet Leptin!

I do not believe there is a more misunderstood disease by conventional medicine than Lyme disease and Fibromyalgia. Many healthcare providers do not even think FM exists to the determent of millions of people. It is estimated that ten million people suffer from these diseases today. 75% of them are women. The reason for that is because leptin is involved, and as you all know it is a sexually dimorphic hormone. These are diseases that affect the fat cells in all parts of our body. They also cause issues with adiponectin, which is also sexually dimorphic. Many women will be glad to know that fact. Understanding Lyme disease actually helps you understand FM very well.

Both diseases cause abnormal activation of an immune mediated pathway that takes over cytokine production in the fat cells that line our GI tracts, respiratory tracts, sinuses, and many other organs. Most know that Lyme is most commonly associated with a tick bite, and the host gets infected with spirochete bacteria. What most do not know, is that this tick liberates a neurotoxin that causes most of its symptoms. This neurotoxin activation is common to many diseases just like Lyme disease. FM, Chronic Fatigue Syndrome, Sick building Syndrome, and mold exposure are just a few. All these diseases activate the same pathway, and this is why they have features that are quite similar clinical findings. Making these connections clinically helped me tie this all together. Since I came to a deep understanding of how important leptin is to our body several years ago, it made complete sense to me to think all these diseases might have a leptin link because of the constellation of symptoms were all tied to specific cytokine activation. This is precisely how leptin resistance develops too. This is how a change of perspective might help a physician see a problem in a new way. It is precisely how Evolutionary medicine prism has allowed me to come to bio-hack just about any disease we face as a species now.

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The Osteoporosis Rx

Osteoporosis is a disease in which the bones become weak and are more likely to break. People with osteoporosis most often break bones in the hip, spine, and wrist. If you think this problem is not common, let me pick up the rock you must have been sleeping under. In the United States, more than 60 million people either already have osteoporosis or are at high risk, due to low bone mass.

RULE 1. If one is leptin resistant, Wolff’s law is null and void, and you are at very high risk for a fractured vertebrae or hip/wrist. You should stop here and go read EMF-8 Quantum Bone for the pathophysiology of this disease. The key features are to increase your spring water intake to 1-1.5 gallons of non fluoridated water a day and strict avoidance of artifical light and the use of pulsed EMF technology devices. This means that “normal conventional wisdom osteoporotic treatments” and exercise will not heal or strengthen a bone until the underlyig pathophysiology is repaired first. When a person has high levels of leptin, it eventually drives cortisol higher and this stimulates even more inflammatory cytokines from cells. As this occurs, LR develops all over the body. Cortisol is one of the major hormones involved in the sympathetic nervous
system. When cortisol is chronically high, as I told you in the Hormone 101 blog, it’s bad news. When someone is leptin resistant, they block osteocalcin’s main function and this causes osteoporosis. This is one major reason why fat people lose their bone. It also definitely proves that Wolff’s law is null and void when you are LR. Even resistance exercise maybe harmful when this occurs. Bone only strengthens when the underlying hormonal terroir is working properly. In LR, it is seriously broken.

RULE 2. Andropause and Menopause are associated with osteoporosis, and not caused by it. In both situations the best treatment to overcome it is to change your diet to a high fat and protein diet. You would be a wise patient to avoid all bisphosphonate drugs until it’s too late. This will be hard to do, because most clinicians will push drug treatments over evolutionary medicine treatments. Remember The Seven Dwarfs of menopause: Itchy, bitchy, sleepy, sweaty, bloated, forgetful, and all dried up…and the bones are real dried up!

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READERS SUMMARY: 1. HOW DOES CONCUSSION, MSG, AND NEURODEGENERATIVE DISEASE ALL FIT TOGETHER? 2. WHO IS AT RISK? DOES AGE MATTER? DO I KNOW ANYONE WHO HAS HAD THIS? 3. IS ANCEL KEYS A PLAYER IN THE MSG NIGHTMARE TOO? 4. HOW IS ALS TIED TO CONCUSSIONS AND TO EXOGENOUS and ENDOGENOUS EXCITOTOXINS? 5. ARE CONCUSSIONS, AD, ALS and MSG BASICALLY THE SAME DISEASE? In the first two blogs (1) (2) in this series we looked at the fundamental neurobiology of how excitatory neurotransmitters and exogenous food additives can cause human disease. We discussed that the mechanism of disease progression is affected by age, species, and the energy status of the neuron at the time of exposure or injury. Today we are going to explore how acute neurologic aspects of cranial trauma relates to progression to long term neurodegenerative disease. We also must remember that these athletes, soldiers, and high school students are simultaneously ingesting huge amounts of MSG and aspartate in a standard American diet. I would hope that every person reading this would avoid exogenous sources of excitotoxins going forward. This is especially true if you have sustained a traumatic brain injury or a concussion in your lifetime. […]

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The Leaky Gut Prescription

Well, we have talked about the gut in three other blogs so far. (1) Could It Be the Gut?: An Introduction to the Brain-Gut Axis, (2) Your VAP = Brain Gut Axis Function, and (3) Why Leaky Guts Lead to MS? Click those links or go to my home page under Brain Gut Axis and find each one for a quick review. We have hinted at the leaky gut as a cause of serious human disease in all those posts. Today we get to focus on the “leaky gut” and how we might offer to treat it.

What is a leaky gut syndrome? It is the complex biochemical reactions that occur in the gut appear to be the genesis of where inflammation initially passes in to our body. We need to realize this and avoid eating the things that cause this inflammation. As I have said for close to five years now this means strict avoidance of omega 6’s, all grains and especially wheat of any kind and very limited fructose (fruit or synthetic sources) The gut associated lymphatic tract (GALT) is the first place where our immune systems interact with the outside world. This occurs right below the intestinal brush border and is our first line of defense. It seems to me that evolution has dictated that this is precisely where the battle between health and disease begin in humans and why our immune system is set up ready on that battle front.

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READERS SUMMARY: 1. What determines our ultimate health fate? 2. What exactly is epigenetics? 3. How does an autoimmune disease begin? 4. Is multiple sclerosis tied to gut inflammation? 5. What is an inflammasome and why is hypomethylation so critical? My first post on epigenetics seems to have stimulated a lot of talk based upon the emails I received. I think we need to dig a bit deeper into this area because it is now clear scientifically that epigenetics really determines our ultimate health outcomes. In fact, it is the easiest way to alter our genomes by modifying our dietary choices. To begin let’s simply define what epigenetics is in 2011. Epigenetics is any mechanism that affects genes without chaining the nucleotide sequence of the DNA. The two major ways epigenetic modification occurs via our diet is via methylation of our DNA or of acetylation of our histone proteins. The amount of methyl and acetyl groups come from our diets. For example, when we have low methylation in our diet, our DNA becomes hypomethylated. Lower levels of methylation correlates with development of higher rates of cancer and with autoimmune conditions. Obviously, none of us wants to get cancer or autoimmune […]

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Could It Be the Gut?: An Introduction to the Brain-Gut Axis

READERS SUMMARY: 1. What is the brain gut axis? 2. What diseases likely are tied to its breakdown? 3. Why might medical training force us to miss the importance of this axis? 4. How did I discover the brain gut axis in my own clinical practice? 5. Did evolution dictate where the initial battle of immunity should lie? When many doctors hear me talk about the brain gut axis I get lots of funny looks. See, this is an axis that we do not formally learn about in anatomy in medical school. We learn about systems in anatomy that are organized as tissues within organs. Physiology is where organ integration and its function is taught. Guess what? We did not learn about the brain gut axis there either. In fact, when I was in medical school and residency, I never once heard or attended a lecture of this axis that I believe is the fifth most important levee in my cellular theory of health! I personally believe that medicine is going to revolutionized by the science that is uncovered in this axis over the next few decades. I believe the diseases that currently have no cure or known cause will […]

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