TIME # 19: IS TIME TOLD BY BIOPHOTON EMISSION?

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THE TAKE HOME: Can light release from a cell tell us about mitochondrial energy status?  Is mitocondrial fission involved in elimination of ROS-producing mitochondria.   Can our cellular light fingerprint tell us about this process I call “mitoptosis”?  Mitochondria self regulate their function by participating in multi-faceted defense of the cell against oxidative damage.  When the cell is under siege by ROS/RNS it releases ELF-UV and this light is the signal for the recycle programs in mitochondria designed to buy us more time on earth.

HOW MUCH DO YOU KNOW ABOUT CELLULAR LIGHT RELEASE?

When one reads through the Roeland van Wijk’s book one could easily conclude that cancer is more a mitochondrial metabolic disease in accordance with the original theory of Otto Warburg. Today’s war on cancer was waged in 1971 by Nixon and this war has been waged on nuclear DNA changes. So far we have no cure and we have spent 1.3 trillion dollars since that time looking under the wrong genome. In the cytosol, there is another genome in humans. That genome is 37 genes large and codes almost exclusively for the respiratory chains in electron chain transport. Today modern oncology continues to cling to the belief that oncogenesis is the product of point or accumulated somatic mutations. The recent work (forty years) of Dr. Doug Wallace seriously blows this view point up.   VIDEO

His video 50:00-59:00 really makes the key points for modern humans.  All diseases are linked to the geometry of the respiratory proteins.  As they spread apart new disease phenotypes emerge from the change in distance without ANY NUCLEAR GENOMIC changes.

This view point is 180 degrees to all paradigms in modern medicine.

Is this why we can’t solve the puzzle of neolithic diseases?  Are we looking in the wrong place for the problem?    Today’s paradigm is built around the old ideas of anatomy and Mendelian genes and not where energy is generated.  Might our bio-medical premises of the 20th century be outdated, and frankly, incorrect?   Physicians are still taught to think about disease from the anatomical perspective that tissue level disease contain anatomical defects.  When tissue defects cannot explain the problem we jump straight to 1953 when DNA was discovered and we blame defective genes.  We’ve been doing this for 70 years and it has gotten us sicker and in more debt.  Physicians are not taught to look at energy defects as the cause of tissue level disease.  This must change.

The belief began with a simple half truth:  All genes are chromosomal, therefore, we must have Mendelian defects present at some level so we look into the nucleus of the cell for the answer next.  Mendelian genetics are only 125 years old.  What if both ideas are terribly flawed because they both ignore the key concept in life, namely energy generation?  In a cell, energy is transformed in the cytosol allowing life to manifest.  Beta oxidation makes exponentially more energy in the cytosol and the Kreb’s cycle can in the mitochondrial matrix.  The more your mitochondria can fat burn the less disease you’ll get.  Today doctors and patients think fat buring is die to the fuel choice we eat.  It turns out this is 100% wrong too.  Fat burning is 100% linked to how the inner mitochondrial oscillates based upon the light that collides with it and released from it.  This idea is contrary to medicine’s core tenets.  It is very counterintuitive to the foundation associations that have become marketing machines for diseases.  So if the disease never gets reversed, your paradigm is guaranteed a constant source of revenue.

In today’s medicine genetics has corrupted our ability to think. We’ve allowed genetic knowledge to narrows our perspective in healthcare, and we’ve forgotten that clinical experience broadens it, by raising your curiosity.   Since modern healthcare cannot solve chronic disease, you’d think they’d be interested why they keep swinging and missing.  They are not.  Just look at how we fund research.  No one wants to talk about how nnEMF and blue light alter the programming of electrons in proteins because our economy now is built on it.

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These ideas are very disruptive to the cancer machine created by organizations. Cancer is now a huge business in health care systems. The ‘Warburg effect’ was an observation made long ago that cancer cells produce energy by a high rate of glycolysis followed by lactic acid fermentation in the cytosol. The cytosol is where the mitochondria lies not the nucleus. This process is also associated with massive loss of ELF-UV light from cells. That data came after Warburg’s biochemical observations. In normal cells, there is generally a low rate of glycolysis followed by oxidation of pyruvate in mitochondria.  Eukaryotic cells are designed to use beta oxidation as their key pathways to delivering energy to tissues to maintain their tissues anatomy.

LIFE = STRUCTURE + ENERGY + INFORMATION

All things in chemistry are linked to what happens to the valence electron in an atom.  It turns out all things in life are linked to what happens to valence electrons in what matter makes life up.  This is how the photoelectric effect works in plants and animals.

Is there a trend in the Periodic Table for threshold frequency in photoelectric effect that life takes advantage of?

There are trends for reactivity in the periodic table, so there is an obvious trend for the threshold frequency of the elements. This trend teaches us about life’s choices in proteins. Does this trend have any bearing on the threshold frequency of compounds formed by these elements in animals and plants?  Look at the chemical compound of chlorophyll used for photosynthesis in plants and hemoglobin in animal blood.  They are almost identical with the only difference the central metal atom.  How does this link to the photoelectric effect?

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The “threshold frequency” is commonly known as the work function, symbolized by F in Einstein’s equation for the photoelectric effect:
Eke = hn – F

F represents the energy required to knock an electron loose, and we would therefore expect any trend to correspond to electronegativities or ionization energies. Remember that E=hn, so that the lower the work function, the lower the frequency of light required to knock an electron loose. This is why plants use magnesium (Mg) in chlorophyll and why humans have iron (Fe) in their hemoglobin. Mg has a work function of 3.66 eV and Fe range hovers around 4.67-4.81 eV. This means blue light is capable of knocking electrons out of Mg atom to make an exciton with ease but it cannot do it to heme proteins with iron.  Recall that plants evolved before animals.  Also recall that not all frequencies of sunlight are present during all light hours witht he exception or Red, Green, and Blue.  Blue frequancies are always balanced by these other frequencies and this is why the photoreceptors of the camera vision of the eye only use these three colors to all us to see.  So why did plants decided to use magnesium chlorophyll?   Blue light from the sun is always present at all hours of the day and since trees and plants cannot move across the tectonic plates; so it makes sense their photosynthetic energy systems are based around magnesium chlorophyll and not iron chlorophyl’s.  It also points out why humans need strong UV light every day at some level.  UVA light is present at most hours the sun is shining.  UVB light is more restrictive when it is present.

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This is why animals and their eyes and skin have evolved a retinal pigmentum epithelium in the eye and melanin on their skin.  This chemical is the photosynthetic pigment that absorbs all UV frequencies.

 

 

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Recall UVA/B light frequencies is not always present during all times of the day and since humans can move they can access stronger light to capture more energy in their pigmented blood proteins and mitochondria. This is also why melanin is a biogenic amine found in animals skins and eyes.  The more UV light they get the more photoactive melanin becomes.  Melanin is the mammalian photosynthetic chemical.  HYPERLINK

Those things that interact with sunlight photoelectrically and this is why DNA and RNA only codes for specific proteins.  Their photooptical abilities is what nature really cares about.  They only work with sunlight when they are hydrated by an exclusion zone of water.  All living things have electrons and all electrons everywhere in the universe are identical with one exception.  Light excites them to give them different quantum numbers.  Life is carbon based. The quantum numbers used to refer to the outermost valence electrons of the Carbon (C) atom, which are located in the 2p atomic orbital, are; n = 2 (2nd electron shell), = 1 (p orbital subshell), mℓ = 1, 0 or −1, ms = ½ (parallel spins). Once light programming occurs, no electron is identical to any other in the universe.  Before light programming all electrons are the same.  This means abiotic atoms are not programmed by sunlight and biotic electrons are.   Your mitochondria was built by nature to decipher the information and energy in each electron it processes to build the structure that life needs to live.  Food electrons are programmed by the sun because they were programmed by it before you consumed it.  When you understand this about electrons, you see how sun light truly sculpts what life is and can become.

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Information is buried in the signals that mitochondria create and use to direct the structure of cells and tissues. All ROS and RNS are free radical signals all born in mitochondria. People seem to forget this very fundamental tenet of biology. This implies that tissue level diseases can result from global energy deficits. It also implies that non-Mendelian genetics that is prevalent in mitochondrial DNA, and this energy production directly controls nuclear DNA expression via the epigenome.

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This is a huge paradigm shift in medicine because our entire intellectual library in medicine is being attacked by this new data from bio-energenics of mitochondria. Dr’s. Nick Lane and Doug Wallace are leading this charge on both sides of the Atlantic while most clinicians do not even know who these guys are.  Our current constructs in medicine only reflects what we do believe to be true, but it lacks the insights to even ask the question what is it, that we do not know, or what we don’t know that we don’t know, that might be behind modern diseases? This question is rarely entertained because we focus solely on beliefs we think are true and mighty. What if all that we believe is based upon a house of cards?

 

This is an unsettling idea to most, but when you understand that a neuro-hormone like melatonin controls mitochondrial DNA, you begin to see how melatonin controls the geometry of the respiratory proteins that control the flow of energy from a mitochondrial to run the cell.  You begin to see why light and the absence of light at night is the most important thing for proper bio-energetics to occur in mitochondria.

If you understand the biology of light, the corollary to this concept, is that light would then be seen to exert massive control over the expression of nuclear genes leading to many disease phenotypes. That has been what the basic science blueprint that has been published has foreshadowed for 100 years now. Modern corporate and government funded data have avoided and ignored this inconvenient truth because of its economic implications.  Our public problem is that our scientists and clinicians cannot fathom this just yet, and as a result the public’s health is in a catastrophic state because our research and clinical focus is off the mark. This lack of focus is brought into sharp focus by modern mitochondrial science and bio-physics. They have both been pointing to this inconvenient truth for 100 years, but the powers in biology, instead, have been mesmerized by the 1953 discovery of DNA and the ancient practice of anatomical dissection (Vesalius) to gain reductive insights about life and food macro’s. This is a bad way to view the modern world.

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HOW DO LIGHT AND MITOCHONDRIAL SCIENCE MARRY TO ONE ANOTHER?

Conditions associated with pro-oxidant states, like cancer are states associated with elevated ROS production, demonstrate increased sensitivity to low-intensity light therapy (LILT). Cancer is very sensitive to low levels of light illumination. It is also well known that red light has massive effects on cytochrome 3 (cytochrome c oxidase) and ATP production.

Cellular sensitivity to red and infrared light, occurs at the level of cytochrome C oxidase, is influenced by cellular redox state. Cellular growth phase, which also corresponds to cellular redox state, appears be another determinant of this sensitivity. In vitro and in vivo, the effectiveness of LILT varies with cellular growth phase of cells. This makes light therapy in cancer very interesting, if you look at it.  Few do.   Proliferating cells are in many cases more sensitive to incident light. HeLa cells (cultured cancer cells), fibroblasts, and epithelial cells all demonstrate sensitivity to LILT, which is more pronounced during the proliferative cellular growth phase of the cell cycle, and in each case, this proliferative phase is associated with elevated ROS production ant their oxygen utilization.

While there is nothing inherently wrong with the current thinking that a rapidly expanding list of mutated ‘driver’ genes and resultant brand of tumor they generate constitutes an explanation, something more is needed—something to unite and simplify. Since we have dry tapped cancer etiology for 50 years you would think people would begin to look into the cytosol where mitochondria exist. The idea that somatic mutations responsible for cancer spontaneously arise through random insult or error during DNA replication in normal noncancerous stem cells is certainly not implausible but based upon what we know know from Wallace’s work it is highly unlikely.
LILT-induced improvements in traumatic brain injury (TBI) and cardiac conditions have been attributed by Oron et al. to rapid elevation of ATP content, increased angiogenesis.  Making more RBC’s makes for more porphyrins and hemoglobin for light collection from the skin to offset the ELF-UV all human cells release to signal biochemical changes in cells.

Here you can see the atomic lattice of nitrogen around different metals. Nitrogen electrons are excited by sunlight and this energy is used by the metal inside to create electric currents from sunlight frequencies.

Here you can see the atomic lattice of nitrogen around different metals. Nitrogen electrons are excited by sunlight and this energy is used by the metal inside to create electric currents from sunlight frequencies.

Making more WBC’s allows for more melatonin protection for our mitochondrial DNA locally and globally within tissues.  Sunlight stimulates this all, if we allow it too.  LILT also increases anti-apoptotic activity, heat shock protein formation, and increase of total antioxidants to stimulate regeneration cycles.  Cancer detection has a quantum component that is being under utilized.  A noninvasive redox measure that may be useful in advancing investigation of LILT in cancer and may one day be helpful in identifying responsive patients is the detection of elevated production and release of biophotons. It is currently believed biophotons come from ECT proteins and mitochondria. My belief is a bit different.  The detection of biophotons, whose production is also associated with the production of ROS and the cellular redox state, represents just such an opportunity for clinical science. Over the last few decades, advances in photodetection have confirmed that many, if not all, living systems emit very low levels of visible and near visible {ultraviolet (UV) and near infrared (NIR)} photons that today are called biophotons. In cancer states, the amount of biophotons released is higher than in non cancerous states. This light loss actually correlates perfectly with the Warburg metabolism he observed early in the 20th century.

Warburg’s conception of respiratory insufficiency (failure of the oxidative phosphorylation or OX/PHOS function of mitochondria) as the origin of cancer, its phenotypic descriptions, and even somatic mutation itself, not only has simplistic appeal, it can also be tested by today’s photomultipliers that measure light emission by cells.

There is another pathway of inquiry being used in metabolic and biochemical sciences.
Some of the primary evidence for Warburg’s theory now comes from nuclear cytoplasm transfer experiments in which so-called ‘cybrid’ composite cells are created in the lab. These cells allow us to examine mito-nuclear coaptation. Tumorigenicity has been found to be suppressed when the cytoplasm of enucleated normal cells was fused with nucleated tumor cells. These experiments are a blow to the modern paradigm of cancer research that looks for cancer etiology within the nuclear genome.

In other words, normal cytoplasm, containing mitochondria from non-tumorigenic cells, are fully capable of suppressing the malignant phenotype of tumor cell. This is where 99% of molecules are EZ water.  Could it be a smaller EZ’s due to a lack of sunlight, are what cancers are fundamentally related too?  It is well established that water is a repository for electromagnetic radition to make a battery.  It is also well established by Burr and Becker in plants and animals that regeneration is linked to the amount of a DC electric current.  Might it be cancer comes from a lowered EZ and lowered DC electric current that turns off fat burning and forces a cell to use the more ancient kreb’s cycle to generate energies?  I think so, beause this is where the data leads me, not some “expert” opinion.

It appears the free radical signal, light frequency release, and electron spin configuration of the free radicals are critical. The amount of oxygen consumed is also linked to this reaction. The reverse situation of this experiment was also performed and is more problematic for the modern paradigm of cancer generation. When the “cybrid experiments” were reversed they showed that normal cell nuclei could not suppress tumorigenesis when placed inside a tumor cell cytoplasm and its tensegrity system.

 

Therefore normal nuclear gene expression, including presumptive normal tumor suppressor genes, doesn’t rescue malignant transformation. This is a big clue that where medicine is looking for cancer cures is clearly the under the wrong stone. The genome is not the problem but energy flows in mitochondria are.

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This may not necessarily prove that every road to oncogenesis has to pass through mitochondria any more than finding centrioles in dividing cells proves that every cell needs functioning centrioles to divide, but it does limit scope of the somatic mutation conception. This should shift the research dollars to the mitochondria and biophoton research. So far to date it has not.
A cytoplasmic origin of cancer, as opposed to a nuclear origin, does not mean that the problem has to be the mtDNA itself. It could be related to the lack of feedback control of the neuropsin/melatonin/DHA regeneration regeneration pathways. It can potentially be the result of a problem in the mitochondrial network that regulates everything from calcium efflux up to the scale of cell division itself. We know that cell division requires the proper release of ELF-UV release at the precise time in the cell cycle and this is controlled by circadian clock genes that are linked to melatonin’s control of mitochondrial DNA. There is however, some exciting new work that indicates disruption of essential OXPHOS proteins encoded by mtDNA induce metabolic reprogramming and cause the manifestation of the Warburg effect biochemically. In particular, it was shown that genetic silencing of cytochrome c oxidase by shRNA expression resulted in a metabolic shift to glycolysis, loss of anchorage-dependent growth in the tensegrity system of the cytosol, and acquisition of invasive phenotypes. It is also associated with a loss of the inner mitochondrial membrane oscillating at 100 Hz and this stops “effective beta oxidation.”  This suggests that defects in the mitochondrial electron transport chain can initiate a retrograde signaling cascade that leads to tumor progression. As this all occurs in a cell, light emission is altered.

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Photomultipliers have been used to further analyze biophoton emission from total organ brain and liver homogenates in cell fractionation studies These are not in vivo situations but they are instructive on light emission patterns. In these studies, mitochondria and submitochondrial particles have been shown to be predominant sources of cellular biophoton emission. This implies that increases in the distances between respiratory proteins leads to higher emission of light from electrons on ECT or from protons inside cytochrome mouths that hit the iron sulfur targets.
Visible and NIR spectrum biophotons, linked to electron-excited states associated with the generation of ROS, are most relevant to LILT and to this blog. In contrast, the origins of UV biophotons are less clear today, and consequently, less clinically useful at this time. UV biophotons are currently theorized to be derived from DNA conformational changes (Popp/Kruse), amplified radical recombination reactions, delayed branch chain reactions in amino acids with aromatic amino acids, and/or direct fluorophore or chromophore emitters.

The data published to date suggest that singlet molecular oxygen, is formed during free-radical processes in mitochondria. This often accompanies lipid peroxidation in cell membranes. This process is also controlled by eicansanoids under the control of the melatonin regeneration cycles mentioned in the Time 9 blog.  Inside of cells, the outer mitochondrial membrane is a remnant of the endoplasmic reticulum of an early eukaryote.  After 600 million years of evolution, this membrane is now connected to the endoplasmic reticulum in humans which is a membrane rich in DHA and eicansanoids.  Both chemicals are known to be photoactive.  This may be a major source of biophoton emission and why altered melatonin levels are associated with epithelial cancers and low sulfated Vitamin D3 levels. It points out a weak link to the UV environmental exposure. Interestingly, the ROS singlet oxygen is also thought to act as a signaling molecule in the cellular response to LILT photo stimulation.

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Biophoton emission has been related to the utilization of oxygen in many papers in the literature.  These are covered in extreme detail in cite 1.   So has the generation of ROS, and the production of electronically excited states in biological systems. Because of this, it has been suggested that biophoton detection could be used as a tool for the investigation of radical reactions and oxidative stress. Many biochemical techniques, which focus primarily on the measurement of biological lipid peroxidation, are now available to assess oxidative stress in living systems. Unfortunately many of these techniques are quite invasive and inappropriate for clinical application. In contrast, biophoton emission provides, on a non-invasive basis, a signal of oxidative metabolism and ROS steady-state concentration that is readily and continuously detectable. It is possible to continuously monitor the metabolism of organs in vivo with biophoton detection techniques.  We can do this with new camera’s today like the GDV camera Ruben and I used to develop the Quantlet.

Thus, in the assessment of in vivo redox status, biophoton detection may become more useful than other assays in cancer, including indirect assays of lipid peroxidation, such as glutathione release, electron-spin-resonance techniques, or assays assessing the evolution of hydrocarbons or malondialdehyde accumulation in tissues.  These are all things we should be looking at in medicine using these new cameras,  but are not.  Conventional wisdom and standards of care are barriers to progress.  It is encumbant on the citizen scientist to begin to bio-hack these aspects of their biology themselves.

Visible and NIR biophotons and red and NIR LILT share some interesting parallels. Both involve visible and NIR photons, the mitochondrial electron transport chain, and the generation of ROS, in particular, singlet oxygen. As previously reviewed, LILT can stimulate cellular metabolism, presumably through photostimulation of elements (cytochrome 3) of the mitochondrial electron transport chain. Furthermore, LILT photostimulation is thought to result in electron-excited states and the increased generation of ROS.

Mitochondrial ROS generation is likely one of the primary mechanisms involved in LILT. As mentioned, Pal et al. demonstrated that, in human fibroblasts, low-intensity helium–neon laser irradiation-induced proliferation was associated with real time transient increases in ROS production. Antioxidant mechanisms have been shown to inhibit such LILT effects, further implicating the role of ROS in LILT signal transduction.

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The mitochondrial electron transport chain is a major source of visible and infrared biophotons. In fact, the metabolic processes involved in producing electronically excited states in biophoton-producing molecules are generally derived from oxidative metabolism accompanied by the production of ROS. Boveris et al. report that “hydroperoxide-supplemented cytochrome c provides a chemiluminescent model system suitable for the elucidation of some of the molecular mechanisms responsible for light emission”.  Biophoton emission increases with increased generation of ROS by the mitochondrial electron transport chain.

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This light is then released down nanotubes filled with EZ water to transfer the energy and information by Fermat’s Law/Snell’s principal.  Mitochondria have a super highway of nanotubes that contain this light information for coherent transfer of the data to all parts of a cell and organism. Why is red light so special for mitochondria? The action spectra for an increase in DNA and RNA synthesis rate has been recorded when “cultured cells” are irradiated with radiation in the 400–860 nm region. The nucleus does not have chromophores absorbing in this region.  Its histones and chromatin absorb in the  strong UV range (350nm).  They key is that these studies need to be done under direct sunlight outside of a lab to see the effect.  Indoor light in a lab does not have these frequencies.  This brings up the question why you need to question conventional dermatology and opthalamology beliefs with respect to UV light being just a toxin and not a stimulatant to nucleic acids in vivo.  If UV light is so horrible for cells ask your skin and eye doctors to explain how DNA has been shown in thousands of experiments to have a spectrum of fluorescence peak at 350 nm?    Then ask them why the two proteins that are tightly associated with DNA, histones and chromatin, both have been found by experiment to delay this UV light release in DNA in all normal cells?  It is a fair question that none have answered for me.

Hyperlink

Some researchers report that LILT and biophotons share another parallel. Like LILT, biophotons may influence cells through some form of photobiostimulation. At first glance, this is an appealing idea yet very difficult to conceptualize, as the two phenomena differ vastly in their functional intensities of light. Low-intensity lasers and LEDs are effective at an intensity window whose minimum is several orders of magnitude greater than the intensity of recorded biophoton emission which is in the ELF-UV range. In our current understanding, this makes it difficult to link biophoton-induced effects to LILT mechanisms because of the power and intensity differences.  The key is, that light links both processes is some fundamental way. Light release in humans cells is oxygen linked.  Data has confirmed that human biophoton emission is oxygen-dependent and reduced in hypoxic conditions. (Sinclair’s NAD+/pseudohypoxia 2013 paper)

What is the evidence you ask?

Just how specific is light frequencies on physiologic mitochondrial function?
The illumination of isolated rat liver mitochondria (nocturnal species) increased ATP synthesis and the consumption of O2. Irradiation with light at wavelengths of 415 nm, 602 nm, 632.8 nm, 650 and 725 nm enhanced ATP synthesis. Light at wavelengths of 477 and 554 nm did not influence the rate of this photochemical process. Oxygen consumption was activated by illuminating with light at 365 and 436 nm, but not at 313, 546 and 577 nm. Irradiation with light at 632.8 nm increased DWm and DpH, and as a result caused changes in mitochondrial optical properties, modified some NADH-linked dehydrogenase reactions and increased the rate of ADP ⁄ ATP exchange. Mitochondrial RNA and protein synthesis, replication of mtDNA as well as both cytosolic and mitochondrial protein syntheses were stimulated by He-Ne laser irradiation. He-Ne laser irradiation increased not only O2 uptake by cytochrome c oxidase but also electron transfer and proton pumping activity of this enzyme.

TENSEGRITY

Generally, in plants and budding yeast mitochondria are mostly positioned by actin filaments, while in higher eukaryotic cells and fission yeast they are distributed by microtubules. Neurons, do a little bit of both. To be properly inherited, fission yeast mitochondria must be reconfigured into a tubular network structure by microtubules. The intriguing thing here is that it now seems that yeast and mitochondria can move and be moved without the action of any motor proteins at all. We’ve known about this since 2003 as the cites show below.  This is something we have suggested should be possible several times before, only now there is some evidence to show it. This idea stands in sharp contrast to the standard view which presumes that despite their comparatively huge and draggy footprint in the cell, mitochondria are somehow nimbly towed about by one or two miniscule motor protein tethers through a dense tangle of cytoskeleton.

It should not be that much of a stretch to go from the idea that the structure and behavior of mitochondria networks is an important part of cell division, to the idea they can control cell division, and therefore potentially control cancer in the differentiated tissues of multicellular organisms. Fission and fusion in mitochondria allow for cellular regeneration and avoidance of cancerous states. The retrograde response in mitochondria is critical when heteroplasmy rates rise so high that mitochondrial quality control is no longer controllable by normal pathway maintenance. Mitochondria appear to use two modes of energy and signal transmission: electrical/electrochemical and electromagnetic (optical). This signaling pathway is triggered by the loss of mitochondrial membrane potential.  This means the loss of charge.  This means too few electrons or too many protons or a combination of both.  In talking to noted medical geneticist and “single gene” champion Shane McKee, about the new review from Thomas Seyfried PhD on the metabolic treatments for cancer, it is probably safe to say folks will be holding on to the somatic mutation theory of cancer for some time.  Shane accepts that mitochondria play a significant role in cancer, but rejects the idea that they can be considered as ‘the root’ of cancer in the sense that the problem originates in mitochondria before it is evident in the genes.  I suggest you reject Shane beliefs and reality in view of the 4 decades of Dr. Doug Wallace’s work on mitochondria.

People live their lives bound by what they accept as correct and true. That’s how they define their reality. But what does it mean to be “correct” or “true”? They are merely vague concepts.   Their reality may all be a mirage for the public. Can we consider them to simply be living in their own world, shaped by their beliefs?

 

SUMMARY:

Melatonin regenerates the mitochondria respiratory proteins. Cancer is a state when the respiratory proteins are expanded and mitochondria have high heteroplasmy rates. Endogenous melatonin production form the eye and skin needs the sun’s signal via these surfaces by way of neuropsin photoreceptor to regenerate our tissues using melatonin as a guardian protector of the respiratory chain in every human cell. The second messenger’s in this system in humans is the triplet state free radicals made by the respiratory proteins in mitochondria. The distance between each cytochrome and the amount of oxygen in mitochondria are quantized to determine what type of free radicals are made. These radicals can limit ELF-UV release from cells or increase it. Cancer is a state where ELF-UV light is released in massive amounts because we cannot retain the light because of lowered electric and magnetic fields being generated in our mitochondria.


Every morning you need the sun to charge separate water in your body in RBC’s and with melanin to create the battery that creates your life.  Sunlight power becomes buried in the EZ of cells that surround every protein in your body.   That life is created by a cadre of photochemical that do things we all rely on to liberate electrons and allow them to be programmed by sunlight to create your life. You need to expose all your surfaces to this signals to make sense of the world around you. The food and exercise guru’s that keep bathing in blue light and never see this message and blame foods and a lack of exercise for their ills. My Time #9 blog shows you what you might miss when you focus only on food and completely ignore light at night.

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We must understand biology as it is today, and not confuse how it is with how we wish it to be. What is published in the textbooks about biology no longer applies. This perspective shift is counterintuitive for most. The universe can be deduced from the smallest part of cell, if one studied it closely enough. That is what I chose to do because it broadened my vision for medicine. The landscape looks different from every branch of the tree.

Make like the Sphinx every morning, while meditating in the morning sun, look to the East and ground and remain as connected to this environment as you can and food will never be your main driver. Light, water, and magnetism works to limit food influence at the confluence of your mitochondria and can help you build endogenous ocular and brain melatonin to treat cancer optimally. It’s that simple a Rx to regenerate your tissues by shrinking your respiratory proteins even from a cancerous state.

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CITES:

  1. Light Shapaing Life, Roeland van Wijk
  2. The Vital Question, Nick Lane
  3. https://www.youtube.com/watch?v=KwbIR2yUziw
  4. https://www.youtube.com/watch?v=ahlDLjf8c90
  5. http://www.biosciencetechnology.com/news/2014/07/total-darkness-during-night-key-success-breast-cancer-therapy?et_cid=4066343&et_rid=652401564&type=cta
  6. http://science.sciencemag.org/content/303/5660/1007
  7. http://m.medicalxpress.com/news/2015-07-mitochondria-oncogenesis-metabolic-reprogramming.html

Comments

  1. Thank you. Love reading this stuff.

  2. I was wondering if taking an DHA supplement that is based on algea would be the best alternative for fresh seafood? The fishoil capsules are not recommended as i´ve learned from Dr.Kruse´s talks since it “steals” something on a molecular level rendering it inferior.

    • For DHA to get into the CNS and PNS it must be in the SN-2 position. Algae is in completely random in SN1, 2, and 3. When fish eat algae they order it to mostly the SN-2 position. So eating a supplement of algae DHA is very low quality for the CNS and PNS function.

      • If fish order DHA to SN-2 after consuming, why would humans not do the same? Do you have a reference/source?

        “Most mental disorders involve elevated oxidative stress that can be quite lethal to EFA’s. Fortunately, phosphatidyls are fatty acids that provide a safe haven for DHA, EPA, AA, and DGLA in the presence of oxidative free radicals. The four major phosphatidyls have choline, serine, inositol, ethanolamine attached to the end of the molecule.” – From Nutrient Power – William Walsh

        Is this an accurate assessment where phosphatidyls are the primary protector of DHA, or would other elements such as melatonin, glutathione, Vitamin E, etc. also play a significant role?

      • Thank you so much Dr.Kruse! that is unfortunate then, so i guess it is only seafood, as you elaborated in many talks about. No other alternative. Still continue to study your work since the past 2 years. Massive body of information and mind blowing! Keep on the good work!

  3. This was yet again another great read, thank you.

    My uncle was diagnosed with cancer yesterday so I analyzed thousands of various concepts against his field, the number one concept that had the highest resonance was…. Where do you live? As soon as I saw this I thought to myself, this is JK 101 your zip code is more important than your genetic code. The second was Met-enkephalin which I don’t really understand. I thought maybe because of the tyrosine residue and its roll in capturing light, also I see that it is a pentapeptide but I’m not sure of the significance of this, or maybe Met-enkephalin just has a similar resonance as opioids that are being used for pain management. The third concept was, wait for it…….. Redox shift mitochondrial DNA, I think this speaks for itself. It’s sad when the average becomes normal and normal becomes extreme, most people seem to be okay with mediocre even when you alert them of their potential years in advance. I mean come on, it’s perfectly normal to chronically watch the blue tube, drink diet soda, live inside a microwave oven, get injected with monkey cancer viruses, and fear the sun. Nothing to see here folks.

    This current blog really is helping to enlighten my current effort in understanding cell energy. As I test a tissue, it can have infection and low cell energy. Does low cell energy precede and allow for an opportunistic terrain for the infection, or does the infection high jack cell energy and drain the cell charge? I’m thinking dead battery syndrome creates opportunity and once we reestablish our charge any infection is kinda a second thought, or is infection really just a teacher providing new information as a means to evolve in relation to new environmental context?

    This months webinar was awesome in combination with Alexander Wunsch’s living photons. I can wait to analyze the Fraunhofer lines.

    You’re a master, thank you for teaching us.

  4. Jack, I really appreciate you being truthful in a world that likes to be asleep in the Matrix and behave religiously. It’s people like you, who uncompromisingly put the truth out there that move the world forward. I consider you in the health / medical field, a Galileo … but someone who didn’t recant, which makes you even cooler in my eyes.

    I studied ancient history and philosophy in college (because I was drawn to fundamental first principles thinking and truth), and you’d be delighted to know that the ancient Greeks and Roman philosophers of the Stoic tradition had two fundamental guiding principles to living a fulfilling life: (1) “Live in accordance with nature” (meaning the natural world and our individual nature/soul) and (2) “Get into good flow.” If you’re interested in learning more, I highly recommend this short book: http://amzn.to/2aPH1BF

    Everything you’re saying on this blog (for me) pretty much forms the scientific foundation / critical thinking work that support what these ancient philosophers have figured out back in the day, and it’s AWESOME to learn from you the REAL SCIENCE behind the profundity of those two simple statements.

    You’d also be pleased to learn that the Ancient Romans took alternating hot (IR) and cold (CT) baths from natural mountain/spring water in their public baths, on a daily basis; they figured out that these were important to public wellness…even back then!

    Keep on rockin’

  5. Rob Hamilton says:

    “Today’s paradigm is built around the old ideas of anatomy and Mendelian genes and not where energy is generated. Might our bio-medical premises of the 20th century be outdated, and frankly, incorrect? Physicians are still taught to think about disease from the anatomical perspective that tissue level disease contain anatomical defects. When tissue defects cannot explain the problem we jump straight to 1953 when DNA was discovered and we blame defective genes. We’ve been doing this for 70 years and it has gotten us sicker and in more debt. Physicians are not taught to look at energy defects as the cause of tissue level disease. This must change.”

    This is GOLD. I’m looking to to future of medicine where we actually can understand and intervene in mitochondrial energetics and cure disease, not just palliate with various compounds and drugs whose mechanisms we still don’t really understand!

  6. To judge from your post, you’re confusing cause and effect here. Your post mentions cytochrome c, but not cardiolipin. The cause of the light release which is indicative of the pathological state your describing is simply an effect of cardiolipin oxidation by cyt-c, as detailed in this paper:

    “Cytochrome c-promoted cardiolipin oxidation generates singlet molecular oxygen” (PDF)
    http://www.producao.usp.br/bitstream/handle/BDPI/36322/wos2012-1518.pdf?sequence=1

    The root cause of cardiolipin oxidation by cyt-c is well understood, as is how to prevent it.

    • Tuck I’ve mentioned it many times before. And the paper you reference talks about two ways they believe singlet SO is made when in reality there are 4. And one more point about your paper: CL is associated with inter-mitochondrial junctions (IMJs). These are electron-dense structures are conserved across species, resistant to genetic disruption of cristae organization. CL is always associated with IMJ in eukaryotes. Your cited paper in its materials section use cell cultures and cell cultures don’t have IMJ’s and without IMJ what CL does does not represent the in vivo situation. IMJ numbers exist in proportion with cellular mitochondrial content and are dynamically regulated with energetic demand, as such they are practically inexistent in cultured cells. This means that their findings on CL are not fully accurate and this is why they only mentioned two ways Singlet SO is made. IMJ are most abundant in cardiomyocytes and this is how CL interactions of the cristae should be studied. Dr. Doug Wallace does studies like this. Recent collectively published data suggests that such specialized mitochondrial membrane structures exist to promote information transfer inside the cytoplasm of eukaryotic cells. CL is linked to heteroplasmy states by spin changes and photons exciting electrons. So it is not me mixing cause and effect, it is that your paper has an incomplete view of how mitochondria really work. In the ubiquitination series, I showed you a loss of cell signaling in cytochrome 1, means redox becomes reduced at cytochrome 1, and this lowers superoxide burst and affects cardiolipin release from the inner mitochondrial membrane close to mtDNA genes at the NADH/NAD+ couple. It also effects CL at cytochrome 3, 4, and 5. Cytochrome 4 has two CL binding sites and cytonchrome 5, the ATPase has 4 CL binding sites. This is what causes the increase in the distance between the cytochrome complexes and increases the % heteroplasmy due to a loss of melatonin control cycle. Wallace has published a ton that melatonin cycles control respiratory gene expression and heteroplasmy rates. After absorption of UV light photons on electrons from foods (carbs at NADH), the photosensitizer, NADH is first transferred to an excited singlet state by the quantized energy in the photon. Then 3 possible decay channels are possible according to QED physics. The 3 cases of decay channels are non radiative, radiative singlet state decay to the ground state, and intersystem crossing to an excited triplet state of the free radical.
      The last one, may also promote a reaction leading to the singlet ground state by either non radiative decay or by radiative triplet decay. The radiative decays are called fluorescence and phosphorescence, respectively.

      According to Foote (1968), two alternative reaction mechanisms exist for the decay of the excited triplet state which are called Type 1 or 2 reactions. They are characterized by either the generation of free radicals (Type 1) reactions, or the transfer of excitation energy to oxygen molecules directly in a Type 2 reaction. Roeland van Wijk’s book discusses these effects in more detail for you to review.
      During Type 1 reactions the triplet state next interacts with a target molecule or protein in a chain reaction, other than oxygen. Stop and think about mitochondrial function now at cytochrome 1 and what should happen seasonally for mitophagy? This is why cytochrome one makes superoxide as its oxygen radical chemical for signaling. This is why seasonal eating is advocated in my book and why ketosis year round might a bad idea when you understand the physics involved. Sunlight is the missing key to all this biochemical talk you hear from food guru’s. Further reaction with triplet oxygen may also lead to the formation of hydrogen dioxide or superoxide. If the electrons from food that are sensed in the NADH/NAD+ or FADH/FAD+ couple and the skin and eye are not sensing the same frequencies of light, the type of free radical a mitochondria makes will not ACCURATELY represent the seasonal signaling. This decoupling of light frequencies thereby effects the downstream events we expect in ECT. Type 1 reactions always result in the release of free neutral or ionized radicals. We use these free radicals to transduce the environmental signals in our mitochondria. This signal controls the distance in Angstroms to the rest of the electron chain. The distance changes affects CL function, not the other way around. It also effects the Q – cycle’s efficiency that controls cardiolipin, and electron flow from Cytochrome 1, 3, 4.

      In Type 2 reactions, the triplet state of the photosensitizer directly interacts with molecular triplet oxygen (3O2) which is then transferred to an excited singlet state of (1O2). During this reaction the electron spins are flipped of the electrons in oxygen. Light does this flip, not dietary fuels, as many have hypothesized in their writings. Both reactions are designed to occur simultaneously but when the environment around a mitochondria is altered by pseudohypoxia, the respiratory quotient can be altered dramatically in these cases. The reason for this is because all electrons in ECT are designed to move to oxygen for reduction because of voltage changes and not pH changes.

  7. LIFE = STRUCTURE + ENERGY + INFORMATION

    This seems to correlate to the 3 legged stool. Energy is sunshine, Structure is water, and Information is magnetism. No wait–sunshine is information too. And so is water. But water and magnetism are energy also. And structure, heck, that also comes with sunlight and magnetism…

    The equation also relates to society. You cannot have a good society without health (energy), so in hard times society breaks down. But health isn’t everything for a society. People need structure (education, culture, religion, language) and they need information to be able to adapt to changes and to gain wisdom. In turn, the structure and information increases health.

    • Awesome! Keepin’ it simple!! It occurs to me that all coherent light (biophotons) found in living systems sings a chorus (information) called life and the more we integrate with it’s flow the increasingly coherent our physical, emotional, spiritual and societal systems become. Biophoton research points towards a whole foods, plants based diet – the fresher the better – as the coherency of light within the fresh, ripe fruits is most coherent at peak ripeness, exactly when the proteins have mostly been broken down into free amino acids for easier assimilation not to mention the same time when some of the free amino acids are combining with other chemicals to produce the amazing flavors that we get with fresh, ripe fruit. Kind of sounds like a liberating doorway 🙂

      Peace

      • Picturing the human body (and by extension society in general) as a symphony, we can either consume garbled life information (processed foods with incoherently structured photons) and have ‘musicians’ that our coherent biophotons must spend time ‘teaching’ to incorporate into the symphony due to a ‘lack of experience’ or we can consume organized, structured, coherent information (fresh, ripe fruit and vegetables) that seamlessly integrates with the symphony.

  8. non geek practical application: make a sphinx – ok i missed my am ritual – i overslept – … now the uv index is 2 – ok – since i missed making all my hormones and exposure to uv light after a certain period of time stops this production – am i harming myself (hormonally) by going out later – i am probably overthinking this idea from my lack of understanding but would like to know anyway.

    and how can 1 time hurt you – but multiple times missing this critical am time –

  9. paolo manzelli says:

    Paolo Manzelli’s Conference at: http://www.LASERFLORENCE.eu
    Theme: Laser Therapy: Equivalence between the “biofotonic field” and “subtle energy” in the coherence of life energy reactivation. ( egocreanet2016@gmail.com)

    Premise: As EGOCREANET (NGOs -FIRENZE), we think about to develop the theory of Biofotons. of F.A. Popp . Indeed we are proposing to develop the quantum DNA working like a LASER ANTENNA firstly proposed by M.Bischof (2005) but we find ostracism of traditional scientific accademies and also we look many inconveniences from those who find it too easy to treat the topic for the purpose of healing serious diseases such as cancer.So it is extremely difficult forus to find a new scientific rationality called NEO-BIOVITALISM which include ‘Bio-quantum activities of DNA in the functional organization of life” (x). Anyway we are trying to do this endeavour starting from some considerations about the “soft-Laser Therapy” within the potential to improve wound healing and reduce pain, inflammation and other diseases in clinical practice
    – (x) : Iona Miller: https://photonichuman.weebly.com/
    ————————————————————————
    Laser therapy, working in the range of low levels of visible or near-infrared (NIR) light may stimulate the “florescent effect” via signalling processes to the mitochondria (which is the main target of laser absorption), but also “Laser Therapy” may be interact through “resonance effect” with the spontaneous production of bio-photons naturally emitted in the range of (200-800 nm).
    In that case the Laser Therapy may develop a complex information and energy exchange with spontaneous “bio-photons” that naturally work to guide the functional organization of life metabolism.

    Therefore we can made a important distinction . a) the interactivity of low level “Laser Therapy” may be seen only as photobiostimulaion of florescent light ; B) but the “Laser Therapy also may be seen as a “coherent photo-biomodulation” of the spontaneous emission of biophotons originally irradiated by the “Quantum-DNA”. In that B-case the response of photo-biomodulation, my be assume a very broad importance for improving healing expecially with low levels of laser coherent light (soft laser therapy) , that has been frequently observed having a much better effect than higher levels of the more traditional “photo-biostimulation”

    So that in the near future of research we may think about a next step in the “soft- laser therapy” as a as a “coherent photo-biomodulation development looking to ameliorate its therapeutic and quantum-biological effects, but now, I need to synthetize the EGOCREANET theoretical appoach on “Bio-quantum activities of DNA in the functional organization of life” as the main task of my report at the LASER FLORENCE 2017 conference
    ———————————————————-

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