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“Pain is temporary. It may last a minute, or an hour, or a day, or a year, but eventually it will subside and something else will take its place. If I quit, however, it lasts forever. That surrender, even the smallest act of giving up, stays with me. So when I feel like quitting, I ask myself, which would I rather live with?” 



I think this perspective, above,  is interesting because it allows one to cope when feeling pain but when it comes to chronic peripheral neuropathy that I see most commonly he is dead wrong. I don’t think there is anything that slowly destroys a human being more than chronic pain. I see quite a bit of chronic pain in my daily job and decided to write a quick blog about it because of the shear number of emails I have received to speak on this topic.

Neuropathy is a malfunctioning of a nerve or a group of nerves. It can be caused by many factors. Some of them are nutritional deficiency, drug toxicity, trauma, vascular damage, poisoning or disease states like diabetes. The one basic premise that is common to all causes is that there is a disruption of normal nerve impulse transmission from the damaged nerve and that information is sent to the central nervous system in the brain and spinal cord for further processing. This malformed messaged could in fact be perceived by the brain as a sensation associated with pain, numbness, or the muscle innervated by this nerve to be non functional. The most common cause in the USA is diabetic neuropathy. The second most common cause is trauma. This could be physical or iatrogenic.

Neuropathy is generally associated with three sensations.

1. Paraesthesia- which is numbness or tingling

2. Causalgia – burning sensation

3. Dyesthesia- which is an unpleasant burning crawling, itchy, sensation in a numbed or dulled area.

Some patients refer to it as real annoying pain that wont go away. The pain can range from minor to intense. In some cases the pain can begin with a non-painful stimuli touching the affected area. If the motor portion of the nerve is also involved movement maybe effected and muscle atrophy or shrinkage will result. Nerves that control autonomic functions like heart rate and blood pressure or gastric emptying can also be effected. When this occurs we generally see changes in tears, salivary flow, erections, urinary retention, respiratory trouble or palpitations.


Usually is made by history and physical exam. A MRI to rule out compressive or disc disease is often done.  Sometimes we revert to ordering ancillary testing like nerve conduction studies. Often times in tough cases to diagnose we need blood tests to rule out diabetes or mineral or vitamin deficiencies that can cause neuropathy. There are genetic causes too but they are generally rare.  One of the more unknown causes of neuropathy is a recent plane trip.  This occurs due to the jet lag and the EMF risk.  Read this hyperlink for further data.

Diabetic neuropathy:

Is a function of the severity of the diabetes and the duration of the disease. The older the patient the more severe the neuropathy seems to be due to reduction in autophagic repair as we get older. The severity is also tied to the HbA1c level, reduction of the HDL level and the elevation of the TG levels. Initially only 8-12% of newly minted diabetics have neuropathy but after 25 years of elevated glucose 60% of diabetics have some form of neuropathy.

How does neuropathy develop?

It begins with a circadian mismatch usually tied to light or the low frequency ELF range.  Both alter calcium homeostasis in cells.  But excessive EMF is not necessary to be the only cause.  Iodine deficiency is a big cause because it causes a loss of myelination of peripheral and central nervous system tissues.  A lack of iodine also means the person can not myelinate their nerves because they can not access the ketogenic pathway to myelinate nerves.  This has two major effects on nerves.  One it decreases the insulation of nerves and can cause a short circuit to develop.  The second is more interesting and more significant.  It would decrease the the DC current of nerve fibers that has been found experimentally to be tied to tissue regeneration in mammals.

Early humans found them selves in an environment loaded with iodine, DHA, and seawater.  Today’s modern humans do not.

Sufficient dietary iodine is crucial for proper ketogenesis in our nerves,  liver and in our brain.  Ketogenesis is critical for myelination of all nerves in humans.  These are just three of many tissues that diabetics have massive trouble with.  When iodine is low,  estrogen levels tend to be higher in both sexes.  This also is associated with elevated SHBG on testing.

Estrogen also blocks the absorption of iodine from the human gut.  So any cause of leaky gut can also be an etiology for neuropathy even in a non diabetic.  I see this many times a week when some one comes in with a normal MRI and classic radicular pain they think is from compression or from a disc.  This is why women have higher rates of neuropathy, MS,  and hypothyroidism than men.  It is also why they have less myelin than men in adulthood naturally.  Myelination is a proxy regeneration because of the loss of the regenerative DC current below the myelin level and outside the axon of nerve cells.

You might be shocked to learn that artificial blue light in your environment destroys iodine absorption due to poor melatonin signaling in the brain.  When iodine is low in nerves over time it causes lower levels of vitamin D and vitamin K2 and atherosclerosis usually develops in the blood vessels that feed the vascular supply to nerves.   You  might be shocked to learn loss of melatonin signaling in the brain and in nerves also increases estrogen levels and,  this in turn,  further lowers iodine absorption from the gut in both sexes to cause peripheral neuropathy.  This is the most common cause of peripheral neuropathy I see in my medical clinic.

As the disease progresses,  blood flow to the nerves decreases because of the development of atherosclerosis from a chronic low vitamin D, vitamin K2 level and iodine. The patients also tend to be dehydrated and have higher BUN/creatine ratio’s as well.  This limits the amount of oxygen and nutrients to the nerves cells. This damage occurs at the vasa nervora. Nerves are fundamentally different in how they transport glucose than other cells in the body.

Membranes of nerves have insulin independent glucose transport mechanisms. They rely on the polyol pathway. This pathway uses polyhydroxyl alcohols. This pathway is the one responsible for many eye diseases like macular degeneration and optic neuritis.  These diseases all affect the ability of the eye to absorb electromagnetic signals from sunlight to send to the retina and pineal gland.

Diabetics have constant elevated blood glucose and this allows nerves to absorb the glucose at a higher rate. That glucose is chemically altered to sorbitol by the polyol pathway by an enzyme called aldose reductase. This sugar alcohol is not used by the cell for ATP so it builds up and causes cellular stress to develop. It also limits the amount of ATP a nerve can make and nerves use massive amounts of ATP to transmit messages. When ATP is limited it limits the ability for nerve to use water chemistry for energy transfers.  This is why diabetics have serious problems with wound healing and with tissue regeneration.  The lack of energy increases overall cellular stress and damages the nerve cells eventually through the action of circadian clock genes on the photoentrainment pigment called melanopsin.

The main effect of this build up of sorbitol is a decrease in a nutrient called myo- inositol. Myo-inositol is responsible for normal nerve conduction to take place. Inositol is a B vitamin compound. The sorbitol causes build up of free radicals, namely peroxides, hydroxyl,  and nitric oxide free radicals. In diabetics or in injured nerves,  it concentrates these free radicals to make a positive feedback loop and worsen nerve function or pain as time goes on. This in turn depletes nerve cells of taurine. (Hansen 2000) Studies done by Terada et al., in 1998 suggested that there was a close relationship between the unregulated polyol pathway and the depletion of carnitine in the mitochondria that leads to neuropathy.  A “carnitine like” analog called R alpha lipoic acid is thought to balance this depletion and is used as a treatment of diabetic peripheral neuropathy today.   It is not as effective as replacing dietary iodine sources in my experience.  I also use high dose resveratrol because it blocks the production of nitric oxide in nerves and increases mitochondrial efficiency,  even in the face of an unregulated polyol pathway.   Resveratrol has massive benefits for diabetics.  The dose I like to use in some cases is 500 mgs per day to 10,000 mgs a day based upon the patient’s symptoms and budget. Resveratrol is not cheap, but I believe it is one of the best treatments we have today that is completely under utilized by my profession. I also don’t advocate the use of any sugar alcohols in the diet because this can worsen the neuropathy from any cause.  When someone has neuropathy I will immediately tell them to use cold, the Epi-paleo Rx, and avoid non native EMF from their cell phones and from any blue light emitting diode in their environment. The sugar alcohols advocate by many in the low carb community  should also be avoided like the plague.  I find it disconcerting that many low carb bloggers have sponsors with these chemicals in them.  They are not good for people with neuropathy.

Treatment Considerations you must consider ASAP:

1. Strict Low carb Epi-paleolithic diet is instituted to lower HbA1c and PUFA content in nerve cell membranes. My suggestion is the read The Epi-paleo Rx book, to see precisely why a ketotic approach is best.

The reversal effect of the diet is not immediate because the lack of fat and iodine is chronic. In my experience, it takes 18-36 months. Interestingly, the Epi paleo Rx is quite high in carnosine. Recently, carnosine elevation has shown to increase telomere length and to directly combat glycation from high blood sugars and high PUFA diets. No one is quite sure yet the exact mechanism but since the Epi-paleo Rx contains massive amounts of carnosine it helps tremendously in treatment of this difficult combination. Another point about diet that must be made: The current American Diabetic Association (ADA) diet is one that favors excessive carbohydrate intake which has a very low iodine content.  Also many modern diets call for low sodium, and this further decreases iodine intake. Go the the American Diabetic Association website and look at it.  It is appalling in my view as a physician, given what we know today about nerve regeneration.

Since America is a country of frying chefs, be very careful of frying any carbohydrates. Think french fries or funnel cakes! Carbohydrates subjected to frying in PUFA oils form the chemical acrylamide, and this compound is strongly linked to the development of peripheral neuropathy as well. Changing your diet to an Epi-paleo Rx and controlling glucose and PUFA intake is the most important and best way to reverse neuropathy.  This must be done with a heavy intake of reverse osmosis or spring water daily.

2. Use of iodine and iodide supplements, R alpha lipoic acid, Resveratrol, PQQ, Magnesium and CoEnzyme Q 10 to decrease cellular stress.

3. Fatty acid balance to reduce peroxide generation. The goal is to decrease omega 6 fats and increase omega 3 fats and also increase gamma linolenic acid (GLA). Borage oil has copious amounts of GLA. So does black currant oil and evening primrose oil. These oils tend to increase blood flow in the vasa nervora to decrease the cellular stress.

4. Very liberal replacement of B complex vitamins especially B1 and B12. Optimization of vitamin D and E levels due to their immune modulating and antioxidant effects in nerves. Use of inositol is also a treatment choice.

5. Zinc and Magnesium replacement.   This only works if you live in a low EMF environment.  Zn with Mg are two of the most common mineral deficiencies in neuropathic pain due to the unregulated polyol pathway. Don’t go crazy with zinc supplementation because it can cause a secondary copper metabolic problem but I can not emphasize enough if you are a diabetic you must supplement with zinc, but only when your inflammation is first controlled with the Epi-paleo Rx.  It helps wound healing out tremendously. In fact, in my surgical patients who are diabetic I usually have them on three key supplements for wound healing pre op and post op. Those are magnesium, zinc, and vitamin K2. The doses vary based upon the disease severity they have and the type of surgery I am planning.

6. Supplementation with NAC and Acetyl- L- Carnitine. NAC is a precursor for glutathione to rid the nerve of all the free radicals produced by the polyol pathway. The carnitine is replaced because it is depleted by the polyol pathway. Taurine replacement can also be done,  but has never been shown to be effective in trials. (Franconi et al 1995.) I rarely have use taurine myself because of the trial data.  I find iodine and water are far better choice for peripheral neuropathy of any cause.

7. Optimization of thyroid hormone function is critical. Most diabetics have high cortisol and altered leptin signaling. If you have not read my leptin prescription post I would suggest a peak at it now. This predicts that their thyroid function will be altered or completely shut down physiologically as shown in any textbook of physiology or biochemistry. This has huge implications for the nerve fiber. In order to a neuron to work, it first must be excitable to a stimulus. This excitability requires sufficient amounts of T3. Remember from my leptin series that leptin resistance cause a spike in production of reverse T3. Reverse T3 is a DIRECT INHIBITOR of T3! This means that no matter how good your T3 level is reverse T3 inactivates it directly. So one can see how devastating LR is to nerve function. Generally, the best replacement of T3 in these cases is Cytomel, which contains peripherally active T3.  You can also use over the counter T2 supplements if your doctor will not Rx meds for you.

8. Consider the use of acupuncture. In severe cases that were unresponsive to the above I have seen decent successes with this alternative treatment.  The effect however takes 48-106 hours to begin.

9. Talk to your pain physician about placing peripheral nerve stimulators on the effected nerve to increase its blood flow by increasing signal transduction. This can work but I only recommend it in cases where nothing else works.  This is rare unless the patient is completely non compliant with the above advice.

Conventional Medical treatment you likely will get today in an office:

1. Neurotin or other antiepileptic medicines, a blood thinner to decrease platlet clumping and decrease blood viscosity to increase flow, and one or several antidepressants for the chronic pain that walks hand and hand with this condition. The side effects really limit their effectiveness. Sleepiness and weight gain and a feeling like your drunk or hungover are common ones I hear.

2. Pain medications that will lead to secondary effects over time. Addiction and chronic pain development due to hyper-excitability of satellite astrocytes in the CNS. I will post a future blog about what opiates to to chronic pain and the how the affect a leaky gut. Safe to say these drugs do little and they cause many secondary problems that are often harder to deal with than the nerve pain they are supposed to treat.


Goldberg RJ, Katz J. 2007. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain 129(1-2):210-23.


  1. Question for ya Doc!

    Great article by the way..as always. But I am wondering if I am reading between the lines correctly; that a person, say a diabetic, most likely overweight, that does not change their diet, get off the SAD, would be wasting their money if they are taking copious amounts of the recomended vitamins? Possible counter productive, or of little help due to the overall issues with glucose and the polyol pathway.


  2. @Dave…..great question. I will answer it tactlessly. If you continue to glycate your body taking my advice here is akin to pissing in the lake to raise its level.

  3. Are there any parallels between diabetic neuropathy and hearing loss?

    I just spent a week with my 85 year old mother and if there is one thing she could pick to have "fixed" because of the huge impact on her life, is the loss of hearing.

    Will the same treatment approach help?

  4. Hearing loss comes in two types…..sensory neural and bone conductive. Sensory neural loss can be a bit like neuropathy but your mom would need to see an ENT to conduct a simple tuning fork test to determine which one she suffers from. Bone conductive loss is more common as we age.

  5. Jack, just wondering, what are some other ways besides a basic paleo diet that I can help my liver function? NAC? Tumeric? I know good gut health is key, but it seems like chicken & the egg where both are needed.

    • Bill…..its clear you have not read the rest of my blogs……the secret sauce for leaky gut is there. Go back to the main page click on the brain gut axis…..and then you can send me a bottle of wine when you see the juice i'm giving you for free.

  6. Nice nice. Clinical nutrition is the definitely under-utilized.

    How does vitamin B12 tie into neuropathy? It seems to be vital for repairing a brain.

    Also, what do you think of glutathione shots for neuropathy, or in general?

  7. I started the LR a week ago Monday. I'm a 43yo female that had the beginning of Neuropathy in 2009 (that's when a nerve test discovered it). I also have Hypothyroidism, Insulin Resistance, obese, insomnia and bipolar. I just had an Hysterectomy on July 27,2011.

    My mother is diabetic with severe Peripheral Neuropathy.

    I can't tell you how much I appreciate your work here! I had just given up hope of getting for a reasonable weight and stopping the chronic pain from my SI Joint and low back! I now have hope again!!!

  8. Grammasmitty says:

    I am on information overload with all the articles you've posted! But I am beginning to absorb. Sure appreciate your personal responses and fantastic advice!

    Question, what do you think of Astaxanthin?

  9. @Stabby Memorize & repeat these words: Wikipedia is my friend. Learn how to use your computer to find answers yourself instead of making work for other people.

    "Vitamin B-12 is a water soluble vitamin with a key role in the normal functioning of the brain *AND NERVOUS SYSTEM*, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of *every* cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production. Vitamin B12 deficiency can potentially cause *severe and IRREVERSIBLE damage*, especially to the brain and nervous system."

  10. Great article, you seem very knowledgeable about nutrition for neuropathy, which is why I am totally confused why you never mention using benfotiamine ? Good research and many people have had complete relief just using benfotiamine by itself and has been around for 10 years.

  11. i have parkinson's FXTAS. parents of autistic child can get it (which I am) but also i have had uncontrollable sweet cravings all my life.

    i'm doing gaps now. it's very low carb. and i'm following the anti candida diet.

    i need to think it's not too late to help myself.

    i have read your stuff but it's way above my head.

    i think u say: q10 and b vitamins for neurological diseases. is that right?

    • @becky It is never too late. I have written a lot about PD and neurodegenerative disease here. Use the Search button to find them in the index search.

      • Hi Jack, I have similar tachycardia with no other symptoms should I be resting more or should I carry on doing my daily tasks like cooking etc. I am on a Paleontologist diet. You had mentioned coffee, would that not increase my heart rate. I got autonomic neuropathy symptoms while on a biologic medication ” Taltz” . Been off of it for 2 months now but the symptoms are still there. My main concern is the silent escalation of heart rate.

        • Paleontologist diet? Never heard of that. heart rate is linked to solar exposure…….if you dont have enough your heart rate variability will suffer.

  12. Julie Mccarthy says:

    Hi Doc,

    Wondering if you ever posted a blog on the affect of opiates on leaky gut. I took many pain meds for years before, during and after spinal surgeries. I don't take them now but they recently prescribed Neurotin again because I still have nerve pain and burning creepy crawlies–does Neurotin affect leaky gut? Also, I have the classic physique of someone with Cushings and had several shots of cortisone in my time–that, with the stress of the surgeries and losing my job, I think my cortisol levels may be through the roof. Have you had experience with patients that have experienced these things and were able to improve their health? How did they do it? I have changed my diet to Paleo- should I address leaky gut first and then do the leptin reset? I have so many questions…

  13. So sorbitol laden zinc lozenges is NOT the way to fight a cold, unless you want to fry your nerves?

  14. Dr, K,

    What about peripheral numbness that comes on while doing the L Rx? I ask because I seem to get it in my toes whenever I start cranking down the carbs – whether it was years ago on Zone or going with a LC version of Paleo/Primal. Fasting glucose has been consistently in 90's and HBA1c has never tripped the T2D level. Could this just be a potassium/calcium/magnesium issue?

  15. is it possible for this condition to only occur on the left side of the body? (arm and leg) and when i go to my doctor what tests should i ask them to run? Thank you so much for all your information…..it is the missing piece to the puzzle for me

  16. reversible? or does the concrete stay on the granite? 🙁 And I suppose I might as well give up thinking the fuzzy thinking of perimenopause is going to lift on the other side of the change

    • @cgk depends upon how much damage. I have several neuropathy reversals………its pretty cool too because the ones that occurred happened in people I gave little hope too. So now I am a lot more aggressive. I learned something from these patients.

  17. I don't have PN but, rather, chronic inflammatory demyelinating polyneuropathy. no pain but have lost much feeling in toes and feet, have drop foot, have lots of muscle atrophy in legs (and yet I still surf!). doctors call it idiopathic and can't help. it is progressing fairly quickly. i did a round of IVIG, 10 treatments, with no effect. anyway … would your RX for PN be equally applicable for CIDP? thanks!

    • @Linter CIDP is a huge breakdown of immunity caused by inflammation and hormonal breakdown. It is usually associated with estrogen dominance and a SEVERE loss of progesterone that decreases Brain derived Nerve growth factor…….and NERVE GROWTH FACTOR!!!! this also destroys vitamin D status. I bet your DHEA level is horrible to because it means the process of autophagy is broken in you. It means your sleep is bad and you cant make BDNF and NGF so the inflammation is destroying your nerves. You need to eat a very ketogenic paleolithic diet with lots of coconut oil, fish, seafood, and lots of 99% chocolate. I also think you need to get your hormones checked and you will see every one I mentioned here is abnormal. Then you will realize that I know something you and your doc do not. Then you can fix them. You need to take control of your health…….medicine cant because they do not realize that this disease is an autoimmune disease cause by gut inflammation by a bad diet. You really need to listen to my talk today at http://www.paleosummit.com. It is free all day today

  18. Jack: thanks for the speedy response. as it happens, i'm going to see my neurologist tomorrow for follow up to the IVIG treatment. could you tell me specifically what tests i might ask him to order, to see if certain of my levels are as off as you think they might be? and i will listen to your talk!

  19. btw / you said: "You need to eat a very ketogenic paleolithic diet with lots of coconut oil, fish, seafood, and lots of 99% chocolate." Are there any alternatives to fish / seafood? I am 57 years old and have eaten fish probably less than 12 times in my life. Seriously. Everything about it sickens me. So … like I said … alternatives?

    • @Linter……alternative? sure. Those lead to mediocre. You must eat optimal to get optimal. Read the HOLY TRINITY STAT. You need to improve your thinking now.

  20. while i work on that, more immediately pressing is my visit w/ the neuro tomorrow. should i ask him to order tests and if so what tests?

    • @Linter you want the truth? You're going no where with them. You must do it yourself. You can ask them to do them……but I already know what you'll hear. Plus none of them would know what to do with the labs. That is another problem

  21. well, okay, i'm left to my own devices once again. have you written about how to "do it on your own"? if not, might you do so in the near future? btw/ my doctors will do any labs i ask them to do or, at least, with only a little balking. as to interpreting the results … that's another story.

    • @Linter copy my response and bring it to your doctor…….and you force the issue. Use your brain here. You have the data!

  22. Well, in any event, I did a cortisol saliva test two years ago:

    morning: 4.7

    noon: 1.7

    evening: 2.1

    night: .5

    at that time, all were within range, except the evening, and it was high.

    My CIDP was bad then, but not as bad as it has become in the last year. Even so, I'd have thought the test would say something about what's going on and it really didn't, from what I can see. Lab was ZRT.

    • @linter get a HS CRP, progesterone DHEA and Vit D level back with free and total Testosterone witha full thyroid panel………including thyroid antibodies……That will cover all you need for a hack. I bet your doc shits the bed…….he wont know what to do……with the results you can head to MDA post them and we will hack you. I have a minion of soldiers over there who are helping take mediocre people and making them optimal…….they are nothing short of amazing.

  23. Thanks. Will do.

  24. Hi Doc,

    I am an MD myself (I write from Sydney, Australia) and today I have accepted to help a mother of one of my daughter's classmates at childcare. She has a diagnosis of motor neurone disease. Obviously progressing despite treatment. I am applying the autoimmune Paleo approach, and asking for bloods as baseline (CBC, Liver function, renal function, electrolytes, CRP, Lipid profile, Vit D, Vit K2, Magnesium, Zinc, Selenium, Phosphate, Thyroid function + T3).

    She eats the typical Western Diet, and is high in processed soy products. All this will change (my wife has volunteered to cook for her lunch and has recruited another mother for dinners.) Under my supervision.

    Do you have any recommendations on how to begin healing the gut (should I start with a GAPS approach or just begin with Paleo?), amounts of coconut oil, supplements and any other blood samples?

    I really need your help on this one please.

    Also, I am a big fan, and would like it very much to meet you at AHS 2012.

    All the best with the book… (I'll wait patiently)

    In the mean time will start with recommendations from this blog post, since is the closest to this mom's condition.

    Hope to hear from you soon.



  25. Thanks!

    Is there a way that I can report progress / ask questions?

  26. wally courie says:

    i was treated by Aaron Vinik at the Eastern Virginia Medical University for diabetic neuropathy. he put me on topamax. i was led to believe it remyelinates the nerve sheathes. he explained to me that most diabetic neuropathy is small fiber neuropathy.

    the testing there was deep. where most people doctors just touch your foot w/ a single nylon filament, the tech there opens up a whole suitcase of different sizes. and u close your eyes so u can’t see it or anticipate the touch. is it A or B? that type of stuff. also tested for cold, pressure, heat, autonomic system damage based on the heart rate variability, i guess. he diagnosed me w/ severe diabetic small fiber neuropathy.

    when diagnosed diabetic my A1C was 11% and i had electric type shocks in my hands & feet.

    the treatment worked. i also self medicated w/ fat soluble vitamin A- benfotiamine. the alpha-lipoic acid is good stuff. the r form is the optically active. life extension sells it.

    i still take topamax.

  27. wally courie says:

    correction: benfotiamine is fat soluble thiamine which is Vitamin B1. i have to keep my A’s & B’s straight!

  28. wally courie says:

    the last articles by Dr. Vinik on topamax and neuropathy were circa 2003. But here is a more recent one (2010):

    “Topiramate improves neurovascular function, epidermal nerve fiber morphology, and metabolism in patients with type 2 diabetes mellitus”


    This study is the first to demonstrate that it is possible to induce skin intraepidermal nerve fiber regeneration accompanied by enhancement of neurovascular function, translating into improved symptoms as well as sensory nerve function. The simultaneous improvement of selective metabolic indices may play a role in this effect, but this remains to be determined.”

    But, somehow, i believe paleo and CT would have got me there quicker, if i had known about it back then.

  29. I have had two colon resection due to scare tissue. Is it safe to say that I have a leaky gut?

    • @Sue……..can’t say right now that is the case but that history sure paints a leaky story. Your past issues can change so bio hack your gut right now.

  30. Amazing Post! This post clearly explains what is neuropathy & what are the best treatment for it.I think this will the neuropathy affected people a lot. Keep on posting.

  31. Jennifer says:

    I get infusions of IVIG I’m on 60mg of morphine sulfate 4 times a day
    .I was diagnosed in 2001

  32. Lilianne Aveledo says:

    I am a 50 year old latin female, who was diagnosed with a polyneuropathy four years ago, and the symptoms of numbness in hands, feet and face, pins and needles, disorientation, muscular weakness, temporary loss of sight progressed slowly during a week. After months of physical therapy my muscular strength came back, yet I felt lots of paresthesias all over my body. I have visited many neurologists, yet none has given me a definite diagnose of what caused me this condition. I was Diagnosed with Lupus 25 years ago and recently, I was told it is a connective tissue disease instead . Based on this, some doctors told me that I seems my polyneuropathy was caused by the immune system and others, that it was a Guillian Barre. What is really killing me are the paresthesias that have worsen with time and the strangest of all, is that they become more intense over anything I eat or drink, with products for my skin, medications, deodorant, make up…everything! I’m really desperate. Please help!! Thanksss

    • Lillian you must get AM UV and IR light via your eyes to help this condition optimally. Try to sit on your porch daily and this light. You could also use a black light in your house when in side.

  33. Milton Hare says:

    I would not have looked up iodine and neuropathy except I happened to take a handful of about 20 kelp pills and got several hours of relief, so I thought, maybe iodine helps neuropathy. I have what is apparently an inherited variety, not diabetic neuropathy. Mine is bilateral, my feet get numb, my legs sometimes feel as if they’re being squeezed tightly. This increases if I’ve used any oil in any form, and, when I am low on water. I eat a handful of nuts and a capful of olive oil, no Omega 6, plus I use flax for Omega 3, but not every day. I take 5,000 units of D3 average, taking a 50,000 iu pill every ten days. I do not embrace a paleo diet. I’m a vegan and a lifetime vegetarian. I take B12 sublingually and in a daily supplement I do notice I get a lot of relief if I don’t eat oils at all and I eat less grains (which in my case would be oatmeal, rice and corn, not wheat) and lots of beans, squash, potatoes. But I’ve now been taking kelp for four or five days and get relief for several hours each time I take a handful of kelp pills. The relief is quite pronounced, and not very long-lasting, maybe four hours. Any thoughts on this?

  34. Excelent article i am glad i found your blog and there are a couple of new insides that i am going to try however i have question for you.
    I have a dapsone induced polyneuropathy for 7 years now.
    The professors that i visited where skeptical because a dapsone induced polyneuropathy is usual associated with a motor polyneuropathy.
    Personally i think that i am living in a hell with this condition.
    So the supplement you propose for diabetic and idiopathic patients could they also work with a toxic polyneuropathy

    • Jurgen Read Ubiquitination 24 blog. To help the neuropathy you need to limit blue light via the eye and add back UV and IR light. To get more info come to the forums and read. You can do this bulbs and tanning.

  35. Hello Sir, My son is 42 years old, has 11 herniated discs, and has recently, (1 month) developed Drop Foot. At first he had no pain, then he could not feel his foot at all, then he began getting sharp pains both up his leg and in his foot. Now the pain is there almost all the time. I don’t trust “traditional” doctors or medicine most of the time. He is extremely overstressed, both at home and at work. He was recently working 7 days a week just to try to keep his 5 year old in private school. His energy level is next to zero. Is there anything you might be able to recommend to help him get his energy back and to alleviate this new pain. He already has B Vitamins, Vitamn D, Magnesium and he also takes Colloidal Gold. I recently purchased some Justrian RX for him, which is 35% Food Grade Hydrogen Peroxide, (Part 1) and Part 2 is amino acids, etc, but he has not began taking it yet. If you would have any idea why he is getting these new pains and what we can do to alleviate his new pain, I would SO MUCH appreciate any input you might have. Thank you so much.

    • CC the key is that he must control his environment, specifically the light environment. You will never get well in the same environment you got ill within. He must get rid of his chronic blue exposure, uses glasses UVEX or Bluetech lenses to do so………..and then add in UV and IR to his daily routine. Read the Ubiquitination series on my blog and read more at the forum.

  36. I am concerned about my husband. 72 yrs, fit, active, non diabetic, but since taking testosterone gel has symptoms of IPN . It’s debilitating to various degrees , more or less, day and night. Can there be a causal relationship between the T treatment and feeling of numbness, tingling and constraint in both his feet/ankles/shins

  37. Dr. Kruse,

    Can anything be done to help with idiopathic small fiber neuropathy – sensory and autonomic? Do all the same treatments you suggest apply to this comdition? There doesn’t seem to be a lot of hope for people who have this condition other than take drugs and deal with it.


  38. What are your views on neuropathy caused by Vitamin b6? I took 100mg B6 supplement on the advice of an Ortho and within days quickly developed neuropathy. I did not catch that is was the b6 for quite some time, but it caused widespread damage. I am very sensitive to it in anything now. What is your view on b6 induced neuropathy and why some can take a 100mg supplement with no problems and others cannot? What could this have to do with diet and other factors?

  39. Laura guerra says:

    Hi doctor, I was diagnosed with coccydinia three years ago due to a hyper mobile coccyx. A neurosurgeon removed my coccyx around two and a half years ago and I was left with severe chronic nerve pain and sensitivity in the sacrum area and coccyx. This limits my activities greatly to the extent that I had to leave my job. What do you recommend to help this?

  40. Richard Linn says:

    Wow Doc, it sounded like you were talking to me in a great deal of the above. I have peripheral Neuropathy been tested electrically (torture) twice. I am not Diabetic, have good blood flow also tested on tred mill and ultrasound, have no pinched nerves MRI’d, and they don’t know the cause. I have No Thyroids so I take 0.175MG Synthroid I/day, I also take Gabapentin 400 MG 4/day, Pramipexole 0.5MG before bed, and as needed for pain Hydrocodone/Acetamophen 7.5-325T two at a time every 12 hours.
    Since starting the Gabapentin I have gained 50 pounds which just compounds everything.
    I see cut out refined sugars, and a long list of supplements, which do you believe I should take that would not interfere with the Synthroid? Thanks, Dick

    • Richard your story is very common and when I hear it I tell people to either hire an engineer to test their environment of go rent to buy a gauss meter and trimeter to hack their environment. The last patient who presented with lower extremity neuropathy like your case we found his BMW seat was causing his issue. When the seat electronics were disabled he began to improve. After 3 months he sold the car.

  41. When I read this story I realized just how similar it was to my condition. One day, while taking a short walk, I suddenly and inexplicably started experiencing intense burning and prickly sensations in the soles of my feet.

    These symptoms persisted for many months before I was forced to accept the unavoidable truth that I was a peripheral neuropathy sufferer. I visited a podiatrist who told me there was no effective medical treatment for this condition. All he could do was write me a prescription for something that would help to take the edge off.

    His offer was tempting, but deep inside I just knew there had to be a better answer. No way did I want to get hooked on dangerous painkillers for the rest of my life and risk damaging my health even more with the unwanted side effects.

    Long story short, I came across some simple natural remedies and stimulating techniques that gently soothed my irritated nerves and woke up my numb, sleepy legs, feet, and hands.

  42. Randy Eichner says:

    I was diag’d with als but i know i have a crazy explosion of candida and neuropathy and als symptoms are not like others[slow atrophy only in hands & shoulders] as well as i am borderline pre-diabetic with a mthfr kick. Sooo im thinking als i bs at least for me.
    Thanks for the info doc.

  43. Lorraine Dooley says:

    I suffer with severe peripheral neuropathy which became worse and out of control in March 2016. .I have constant burning in both feet and ankles the majority of the day and I must keep my feet in ice water to keep my feet cool. I also have electrical shocks, crawling sensations up my legs, and stabbing pains, but the burning is the worst. It feels like my feet are covered in hot coals. I take 2400mg of Gabapentin daily which I have been taking for more than 10 years. I also was on Cymbalta 60mg per day until my neurologist increased it to 120mg per day which caused an excruciating, constant headache that lasted over 3 weeks. After my doctor weaned me off of the Cymbalta I was put on 25mg of Nortriptyline twice per day. I only took one dose and 3 hours later I was having severe abdominal pains, spasms, and cramping right below my diapharm. This episode landed me in the hospital with me having to have my gallbladder removed. I had never had gallbladder problems before. Just as I never haveheadaches. I am now only using the Gabapentin which I feel does no help at all. So my questions:

    1. I spent two weeks in Ecuador in April and my feet did not burn. The altitude was over 8000ft. Could the change in altitude had a possible positive effect on my neuropathy?? They did not burn the entire time.
    2. Is it possible that marijuana could help relieve the burning pain in my feet??

    I am willing to try almost anything. Thank you for any answers you may be able to provide.

    • 1. Yes……neuropathy is due to a poor charge in the brain that gets distributed from it to the nerves. So at elevation you get way more UV and this is the fastest way to recharge your body via the eye and skin to help this assuming no glasses contact and limited clothing.

      2. Yes but smoking anything lowers oxygen and ruins mitochondrial function so the route of use is key. Smoking anything is not smart.

  44. Kevin Merritt says:

    I’ve seen a neurologist that did fairly extensive testing and his diagnosis is idiopathic peripheral neuropathy. This article is under diabetes – does all of this article also apply to idiopathic PN? If not, what portion applies?

    • Kevin neuropathy is due to a lack of perineual DC electric current. It links to the your ability to turn sunlight into a DC electric current in your tissues. Solar intesity stimulated the oxygen spike in both the sea and air 600 million years ago and that low quantum yield affect many people with idiopathic neuropathy too because their mitochondrial function is poor in their neurons causing the lack of power and symptoms. When you choices in life take away the sun, you effectively lower oxygen levels in your environment and this effects the distal end of mitochondria as the terminal electron acceptor. As a result, our mitochondrial become pseudohypoxic and and NAD+ falls at cytochrome 1. This lowers the voltage of the inner mitochondrial membrane and energy drops and neuropathy become more likely when this process occurs in neurons. This lowers the redox potential across the inner mitochondrial membrane and SLOWS the spinning ATPase. As mammals became more specialized they relied heavily on their blood’s ability to make energy from phosphorus laden proteins and sunlight collisions to generate hydrogen. Anything that lowers the quantum yield of sunlight directly affects blood chemisty, the level of hydrogen, oxygen, and as the terminal electron acceptor in mitochondria where that de-energized blood heads like your brain. When the brain is deficinet in energy the nerves in the extremities undergo a brown out. Neuropathy is akin to pulling the plug out of the wall of an electric device. Animals are photoelectric devices that need both the sun and oxygen to maintain their neural function over time. If take away sunlight, magnetic flux from grounding and oxygen organisms cannot produce enough energy to support their more complex designs in their nervous systems, and they begin to fail and neuropthy becomes the result of a lack of incident energy sources from sun light and grounding.

      • Kevin Merritt says:

        Thanks for your response.

        I’m 59 and developed PN about 3.5 year ago. Initially it was just numbness near the end of my feet. It has progressed to numbness/tingling/burning in my feet up to my knees. The pain is not bad enough for me to consider something like gabapentin. My neurologist says my PN is “mild”. In addition, this year I was diagnosed with osteoporosis, though I’ve had it for a while (I’ve lost almost 2 inches of height). For 35 I thought I was allergic to dairy, I just started eating dairy this year. I also have fairly bad varicose veins. I’m active: walking, skiing, and a lot of cycling. I’m a little over 6’2″, and weigh around 180 lbs. I found your website when searching for ways to improve my PN, however I see you have an Rx for osteoporosis.

        What would you recommend as the first steps to address my PN and osteoporosis?

        • Kevin Merritt says:

          I meant “For 35 years I thought I was allergic…”

        • PN an osteoporosis are both diseases linked to a lack of proper sprectral density of sunlight.

          • Kevin Merritt says:

            So I don’t need to start a epi-paleo diet? I don’t need to check if I’m LR? Or should I do those… and should I do anything else?

          • Kevin I don’t know much about you. That is why we have a journal part of the website The blog is done to educate yourself and read a bit more about bio-physics.

          • Kevin Merritt says:

            You wrote: “I don’t know much about you. That is why we have a journal part of the website The blog is done to educate yourself and read a bit more about bio-physics.”

            I’ve started reading the blog and there’s just so much information. My endocrinologist wants me to start traditional meds for my osteoporosis so I’m looking for some initial guidelines to get started.

          • Read the forum start a journal and compare the guidelines you find here with the ones you get from your doc and then make an informed decision. It is not that hard.

  45. Hello Dr Jack

    I am great fan of your work, from cold thermogenesis to reducing EMF I am following all. I am suffering from Diabetic Retinopathy & lost my ability to read and write, I use Screen reader software. Your article on neauropathy is very useful, Can you please help me in these questions.

    1. Can diabetic retinopathy be reversed and vision regained
    2. I am planning to follow your advice on grounding and looking at sun, will that help ?
    3. Any nutrition protocol you recommend

    Thanks in advance

    • 1. I think it can be but the diabetic has to completely re-tool their envieonment. Few will do it in my experience.
      2. Why would I have mentioned it?
      3. nutrition cannot fix a disease linked to poor light in the environment. My book on amazon covers what type of electrons you should consider eating in a reversal process.

    • What about them? Those are pardigm supporting links. If they worked no one would have neuropathy and yet it grows exponentially as we keep living inside more and more connected to the internet.

      • Whole plant diet is a CW paradigm? The results are encouraging. Curious to hear your thoughts on what could have brought about those results.

        • A plant diet is food dogma. This site is not about food dogma or a paradigm. It is about teching people about the physics of organisms.

          • Interesting that my response/question was not approved. Makes me question the integrity of this site when actual questions are ignored/censored.

          • I think your questions were answered. You might not like the answers but that is not the problem. That is your concern.

  46. Thank you so much for this website and this article. I have Trigeminal neuralgia and I try to do my best with food and supplements (b12, multi, c, flagseedoil). I vallue your oppion and expertise so I was wondering about your thought on TN? Thank you verry much.

  47. I have idiopathic neuropathy, and my myelin sheath is damaged.
    No deficiencies so far, no viral or bacterial causes. Sensory and motor are %100, NCS and EMG shows slowing down on responses.
    After amalgam removal, progression of the disease is down to (almost) zero.
    I’m chelating with low dose chelators. During each round, I have at least %50 symptom relief. In between rounds, it’s hell.
    I haven’t tried iodine yet but D levels are normal, Mg and B12 normal. No diabetes.
    Any ideas?

  48. Hi, I’m an Aussie male with PN living in Melbourne Australia. I really like your views. Can you give me the name of anyone I could see in Melbourne who shares your views? Regards Steve

  49. Alex flood says:

    Hi jack,

    I have been diagnosed with mmn, and am slowly losing use of my hands, as well as a host of other symptoms such as fasiculations, fatigue, cramps, confusion and anxiety. I’m a 26 year old jewelry maker and metalworker so obviously this is terrifying for me. I’m responding to immunoglobulin therapy but the disease is progressing dispite this. I’ve been following the AIP diet but am thinking about trying a nutrient rich ketogenic diet, do you think this is a good idea? Do you have any knowledge of my condition? I’m looking for a good practitioner to work with.

    Kind regards


    • Alex as you know MMN stands for multifocal motor neuropathy. MMN is rare and believed to be an autoimmune disorder. An autoimmune disorder develops when the immune system malfunctions and creates antibodies that attack and cause damage to a part of the body. In MMN, the myelin sheath of motor nerves is attacked. The myelin sheath is the protective covering over nerves, which aids in sending nerve signals from spine to muscles. This attack on the myelin sheath results in muscle weakness. I believe all AI’s are due to inferior environments we allow and this cause immune incomptence because of electromagnetic interactions are disordered between the RBC/WBC and the thymus and bone marrow where our immune cells wait to be programmed. Proteins in our tissues and foods we eat are in electromagnetic communication over a wireless network in several ways we do not appreciate. One, wireless network for the entire food web is photosynthesis. The other is polarization of our protein polymers by unpolarized sunlight. These optical magnetic effects are some of the key ways “immune competence” is maintained and strengthened or weakened and destroyed. These non native electromagnetic fields can interrupt the wireless process designed by nature. These natural processes are linked directly to the cell’s redox potential. When your environment is suboptimal and stealing energy from you chronically you cannot give your immune cells the proper signals to do the things they should do. The higher your cellular redox is, the higher voltage one contains in their cell water and on their cell membranes, therefore, the less one has to worry about this nano-particle battery interference from non native foods and toxins modern humans have created.

      The lower your redox potential the bigger issue this becomes for the person. People need to understand that redox potential is deeply related to both magnetic and electric fields that are linked to the cells present in blood plasma that are proxies for the immune system and the “cell ferry boats” that carry light to and from the sun to allow cells to build the redox potential using solar light.

      Paramagnetic vs Dimagnetic.

      Paramagnetic = drawn to magnetic fields. Oxygen and DHA are paramagnetic.

      Diamagnetic = not drawn to magnetic fields.

      I hope you begin to realize that RBC’s and platelets are strongly paramagnetic. Neither cell has a nucleus, and as such, they can vary naturally between dimagnetic and paramagnetic state depending upon the environment they travel to and from in our body. Conversely, WBC’s do not have this advantage of RBC’s and platelets, because they have a nucleus and all nuclear bases have a magnetic potential. Magnetic effects on Earth are prominent at night and less during the day because sunlight and heat lower magnetism by the Curie point. Electric fields are more common between light and protein’s side chain electric fields to act an antenna. So this is why all WBC’s have a very specific circadian regulation tied to night and day and can be seen in a peripheral blood smear done during day and night by doctors. I used to do these in residency but modern doctors no longer do this so they have not learned about these diurnal changes.

      During nighttime, the Earth’s geomagnetic field is stronger and our body pays deep attention to this small change. In the absence of sunlight it allows for a higher magnetic field locally in our tissues and blood, and as a result, more WBC’s tend to be reelased into our blood plasma. These WBC’s are loaded with melatonin. Melatonin sulfates many of our lipo-proteins to work better in sunlight. Melatonin is then delievered magnetically to all part of the body during sleep to help repair the mitochondrial DNA because melatonin most vital function is to maintain energy flow from the respiratory proteins. The opposite effect is found during daylight. Today most labs are drawn during daylight so modern doctors have not seen this effect.

      Daytime, de-magnetizes our tissues and this increases pulses of oxygen to our mitochondria as we awaken. So we slowly become “de-gaussed” by UV light as it appears post sunrise, and this acts to lower inflammation, improve oxygen delivery, and you can optimize our innate immune system by improving is competence. WBC’s should be lowest during this time. When you don’t “de-gauss” or “de-magnetize” your circulatory system properly between night and day you can stimulate autoimmunity because of altered magnetic effects on T-regulator cells. This can be due to many stimuli we face in life, like nano-particles talked about in link below. Once you get an altered magnetic stimulus locally, it also induces electric changes in the protein side chains in our tissues. This is also a wireless biologic effect. In those tissues affected, that can lead to many illness of the immune system we see today (like auto-immunity of MMN).

      Just understanding the circadian flow of RBC’s and WBC’s gives us that clue at what in our environment maybe harming us. Most people and doctors today are not aware that the cells in our circulation have their own circadian cycle linked to weak magnetic field and variable oscillating of electric fields from our proteins between night and day. Many classes of immune diseases can be linked to nano-particles, foreign or domestic, that are capable of altering electric and magnetic fields in tissues. This makes most autoimmune conditions related to breakdowns in biologic wireless comunications that occur across light channels that work between the sun, proteins and our immune cells in blood. For the Quantum clinician these conditions can be thought of as electromagnetic disruptions of a wireless signal from the environment to ruin the communication system that nature built. This makes AI’s not a food related. Some foods, like modern wheat and grains have had their nucleic acids altered by man, and they can acts as nano-particles to ruin the communication. The idea that auto-immunity can be solved with dietary changes alone, is a horrible meme (half truth) that needs to end if we are to reverse theses electric and magnetic field problems. This explains why these disease were non existent 200 years ago. This is why all AI’s are deeply associated with low Vitamin D3 levels in the blood. This finding acts as a proxy to an electromagnetic signaling breakdown. Humans can only make Vitamin D3 from UVB light in their skin during the day, during certain parts of the season depending upon your latitude, altitude, and your population density!

      UV light is also fully capable of “de-gaussing” (de-magnetizing) blood to allow it to release oxygen locally because of the higher temperature locally from sunlight to make electron spins in hemoglobin more random so that paramagnetic oxygen is released to mitochondria naturally. This is why venous O2 is higher in people who get sensable solar exposure and this is absent in people with incompetent immune systems for any reasons such as nano-particles, virus’s, and bacteria, fungi, or toxins. You’ve got to hack your environment. It likely is the real problem behind your MMN.

  50. I appreciate your work in educating and giving people direction. I was trying to detox from a chemical exposure – part of that was near infared light therapy. I must have been too close to the light one evening and didn’t have the timer on. I woke up with a burning sensation. Now my face and upper body feel like there is a sunburn sensation that comes and goes but without any burn showing on the skin. I am sweating more, my mouth is dry and my muscles sore and it seems worse even after discontinuing the light. The primary doctor and dermatologist- who also practices functional medicine say I will get better but I think I did something awful to myself. I have gotten three glutathione injections in the last two weeks, I am taking kelp pills, pure encapsulations liver dx, magnesium at night, and now some alpha lipoid acid after reading your article. My detox diet is similar to what you recommend so I don’t have to make too many adjustments.

    I don’t know enough about what I could have done to myself except that I damaged the sensory nerves in my skin. It’s worse when I am laying down so sleeping is difficult. I realize that it is not practical for you to give me specific medical advise. I don’t know enough about nerves to know if there is some sort of regeneration that could occur or if at some point they settle down. Do you know of any information on infared light burns like I have described? thank you

  51. I’ve shared the info on Neuropathy with many others and just want to say I’m a long time users of Grape Seed Extract, Resveratrol and/or Pycnogenol.

    I deal with bodywide OA and nerve damage from a hip replacement in 2010.

    I’ve been taking the OPC’s for over 22 yrs.

  52. Brian Sharkey says:

    Would the info in this blogpost apply to someone with CRPS from a wrist fracture? My wife has persistent pain, stiffness and swelling in her wrist/fingers 16 months after the fracture. She also has EXTREME sensitivity to cold in that hand (and extreme SOOTHING from warm running water!).

    Can you point us in some pertinent directions? Thanks so much for your time!

    — Brian

    • Yes. Read this: CT increases the DC electric charge to deuterium deplete cell water and mitochondrial water so H+ protons can be controlled by the solar spectrum. All quite orderly for the mitochondriac with CRPS. Usually the CNS gets loaded with deuterium and the CRPS gets worse as they accumulate and are not moved. This is why I love Cold and red light from the sun for this condition. I rarely face it because most of my clients listen to me and get out in AM sun a ton and drink deuterium depleted fluids. https://www.linkedin.com/pulse/why-did-neo-choose-red-pill-jack-kruse/

  53. Most healthcare professionals will tell you that you are stuck with this neuropathy forever, and that it cannot be treated. They will also typically tell you that your best option is to “manage” the symptoms with a variety of powerful, prescription medications.

    Well, I found a better approach got rid of my neuropathy permanently…



  1. […] is why cancer patients have higher risks for developing multiple neolithic diseases as they age. Peripheral neuropathy and pain is one such example. Those with low HDL levels or frank liver disease tend to make the […]

  2. […] vitamin. Glutathione is the bodies major antioxidant and it acts to protect neurons under assault. Alpha lipoid acid and PQQ have major beneficial effects on mitochondrial function in nerve cells and improve energy […]

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