1. WHAT ARE THE IMPLICATIONS OF BRAIN GUT 4 AND 5 FOR MODERN HUMANS?
2. HOW DOES ENVIRONMENT SIGNALS GET TRANSLATED INTO THE LANGUAGE OF BIOCHEMISTRY?
3. WHAT MAKES SHELLFISH SO DAMN SPECIAL TO HUMANS?
4. WHAT ARE THE BRAIN SPECIFIC NUTRIENTS OF THE EPI- PALEO TEMPLATE?
5. DO YOU THINK OF FOOD AS HORMONE INFORMATION AND NOT A METABOLIC FUEL?
GEEKS: The implications of Brain Gut 4 mean that to develop a brain seafood is required part of the program to maintain it. Nutrients and many other environmental factors have also been found to influence epigenetic programing of our DNA either directly or indirectly via metabolic sensors. Peroxisomal proliferator-activated receptors (PPAR’s), the vitamin D receptors, and the retinoid X receptors (RXR), and the retinoic acid receptors (RAR) are all examples of the nuclear receptors that interact with the brain cell membranes to control inflammation and metabolism all over our bodies. It turns out that PPAR’s are the receptors that are at the crossroads of where inflammation and metabolism actually cross. These are specialized lipid sensors that pay attention to our balance of omega 6 and 3 levels. 3% of the human genome is directly or indirectly controlled by the endocrine functions of the Vitamin D system. This shows you how environmental signals are intertwined into the expression of DNA in humans. The Epi-paleo Rx controls inflammation at a hormonal level in the brain better than the more famous paleo diet.
NON GEEKS: What we eat is really damn important when you have 3 lbs of lipid in your head called a brain. If you eat outside our design you get sick.
Levee 13 in the Quilt talks in depth about the effects of certain lipids on PPAR. It turns out DHA/EPA have massive effects upon it. Moreover, it also turns out that fish based PUFA (DHA) is also a ligand of retinoid X receptors (RXR), and RAR binds most of the forms of Vitamin A in our bodies. Remember from the Hormone 101 blog to make hormones we need Vitamin A and T3 to be present in good concentrations to convert LDL cholesterol to pregnenolone. Pregnenolone then undergoes transformation to the rest of hormone chain in humans, provided cytokine levels are low. That hormone chain ends in Vitamin D production making it an ideal way to tell us what is going on in that engine.
DHA, the fat in shellfish and seafood, has direct epigenetic affects on human epigenetics: Think Levee 14 of the Quilt
GEEKS: Not only does diet induce immediate changes in DNA activation but it changes its genomic expression by altering the organism’s hormonal status to change the genomic body plan. This is how epigenetics controlled the growth of the human brain, spine, gut, and hind limbs. These are the things that separates us from primates. It is not clear that our genes are not where our major differences are found. Humans are the only mammals that can induce DNA changes just by the way we think. We know that DNA activation and expression occurs with thoughts from functional MRI data and PET scans on human brain function.
NON GEEKS: The food we eat completely determines what kind of health we will have because of the way Mother Nature created us.
Many people in the paleosphere call this area the mind/body connection, but I find this to be a misnomer. The mind is the sum total function of the central nervous system (CNS) and its endocrine secretion is called a thought. That secretion can directly up regulate DNA and RNA activity with gene expression and protein formation. This means that a thought has a tangible action. This ability is found in the biochemistry of the DHA molecule itself.
Few people realize the possibility is that DHA in vivo plays a more direct role in neuronal signaling, in which some special properties conferred on the membrane by DHA chains exert an influence on membrane electrical phenomena (Bloom et al. 1999) This implies that the DHA molecule itself has some special electrical abilities and can exert quantum effects in vivo. The 6 double bonds in DHA allow for its electron cloud in the molecular structure of DHA to become a very special fatty acid with respect to unique properties. Humans exploit those advantages more than any other mammal on this planet. It has been put forth that some polarization of π-electron clouds might occur in the DHA structure, and perhaps even be transmitted from one double bond to another, either within a given chain, or between neighboring chains in the membrane. This means that DHA has different properties in the lipid structures of the brain than it does when a researcher studies it in the lab. It implies these effects are lost when fish oil is in a pill form outside of its evolutionary package of shellfish. This is why supplementation falls far short of eating fish. But why you ask?
When DHA molecules are adjacent to each other in a tissue like the brain the π-electron clouds actually are closer together in space than they are when the DHA molecule is alone by itself in a pill or in a liquid state. This unique ability allows for DHA in a membrane to be come its own receptor in a membrane to allow for amazing electrical abilities. This is why DHA is so special and has been conserved by evolution in the nervous system of all life forms and not replaced with the more common land based form of PUFA’s like DPA we mentioned in Brain Gut 4.
The molecular magic is so impressive, that Roger Penrose has shown how consciousness can be explained by the quantum effects of this one fatty acid. In this molecular arrangement it would allow for gamma coherence of the neural microtubules found in the brain’s substance. This chemistry explains the effects of anesthesia and of consciousness, which have not be well described anywhere else in the biologic sciences. It appears the brain is built upon a special fat that allows for quantum effects to happen routinely. These measurements have actually been made in vivo in NMR experiments and electron tunneling experiments. These tunneling of electrons is also found to happen in mitochondrial electron transport respiratory chains as well. Many bloggers, so fond of bone collectors data, laughed at my ideas of quantum biology in the evolution. Now you know why they do. They dont get it……and never have. Just like their mentors and idols and the scientists that created the modern evolutionary dogma we all believe today. Today, we need to question that too.
Moreover, this evidence that these things happen within nanoseconds in the cell membranes of neurons are found in vivo experiments done in medicine daily according to functional MRI data, and EEG strips in all of us that doctors order daily. These abilities are also unique to humans. It’s nothing short of amazing to think evolution can move that fast on a micro level but still not affect the phenotype of the organism in any great macro way. Another paradox of life revealed I guess done by DHA in vivo. (link)
GEEKY INFLAMMATION LINK: We also know today, that epigenetic modifications usually involves activation of NF kappa beta at some point in the biochemical pathways of life. Therefore we must, consider inhibitors to NF kappa beta in future additions to “The Quilt”. We now know that DHA is one of those inhibitors of NF kappa beta. This implies a diet high in DHA not only is required for a complex nervous system but it also predicts excellent longevity because of its intranuclear effects on the main “911 controller” of the cytokine storms that cause inflammation and neolithic disease. These findings are nothing short of amazing, and help explain why brain DHA levels correspond directly to leptin levels and of mankind’s underlying hormone balance on labs.
NON GEEK: DHA has the built in ability to be super flexible for cell signaling and highly conductive electrically, but it protects itself from oxidation because of the quantum effects of its electrons. Paleo dogma tells you PUFA’s are bad. Well DHA is a very unstable PUFA outside the brain, but because of those 6 double bonds and its special electron cloud when it is densely packed together, it becomes a PUFA superman chemical. Outside of the body, it is Clark Kent because of a loss of quantum effects on its electron clouds. Remember when people made fun of this post? Be careful what you call bullshit on, when you are not aware of what you really do not know. Food and their electrons matter more than anyone in Paleo could imagine. I was giving a huge hint back then.
Is DHA ancient even for Mother Nature time frames?
It turns out from molecular biology we have learned, that DHA, Vitamin A, and Vitamin D are all ‘molecular dinosaurs’ as environmental signals to the all neural structures in life. DHA and vitamin A, in particular have 600 million year molecular history as sensors in the visual system of all species known to exist in Earth’s history.
A report in 2002 by the United Nations Children Fund showed that brains world wide are being deflated because of a shortage of certain dietary nutrients like iodine, iron, vitamin A and zinc (Ramkrishnan 2002). They reported that malnourished humans have smaller brains in size and reduced cognitive abilities by 5-7 IQ points, when iron is deficient. 13 IQ points is the cost of a low iodine level. I see this daily on MRI scans in my clinic. We are what we eat. When a human brain is ‘ill fueled’ these days we have the capability to measure it with an MRI or a neuro-cognitive test. The evidence worldwide is that we are a species in decline because we are drifting further from the diet that caused our brains to form initially. I mentioned this in my Paleo Summit talk with Sean Croxton. Well, here is that proof of that statement I was criticized for back then.
When you eat “food-like products” you acquire illness like diseases!
We have moved more to a diet designed to put empty carbohydrate calories into our guts with synthetic man made oils or oils of plants. These moves may help spread out resources to avert hunger world wide, but they have led to a mediocrity of our species in the last 100 years. We may not die of starvation but we are causing our ‘cognitive de-evolution‘ decade by decade. This is obvious when you look at the the recently rising prevalence and incidence in autism, ADHD, AD, and Parkinson’s disease. DHA concentration is directly correlated with disease. A key characteristic of DHA (ω3) deficiency is reduced learning capacity and behavioral pathology seen in humans. This was first described by Michael Crawford in London. The behavioral pathology in an ω3 deficient primate was also shown in Dr. Joseph Hibbeln’s work at the NIH USA (Hibbeln et al. 2005, 2007). It is clear that DHA is directly tied to human brain power. Nothing else in biology accounts for it. Dr. Remko Kuipers work is also important here and his upcoming talk at AHS 2012 should be a must hear!
SAVING DARWIN’S REPUTATION?
Moreover, it perfectly vindicates Darwin. Charles Darwin in The Origin of Species (1868) stated there were two forces in evolution, natural selection and the conditions of existence. Of the two, he said, the latter was the most powerful. Most people know about natural selection but few know about the latter. It turns out Darwin was more right than even he knew. This belief almost cost Darwin his legacy because he spent the rest of of life looking for ‘epigenetics’ in an idea labeled “Pangenes”. He believed that Pangenes were responsible for translated environmental influences that have now become known as epigenetics today.
However, Weismann (1893) rejected this view completely, in the all sufficiency based on experiments in which he cut off the tails of breeding rodents (experiments wrongly tied to Lamarkian ideas incorrectly) and observed that subsequent generations still produced tails. That set in train the present paradigm of the modern synthesis of evolution, and genomic determinism within which the DNA is seen as the sole dictator of difference and evolution, and to the notion of the “Selfish Gene” was set forth by Dawkins recently.
For the non geeks : Genomic determinism means DNA and genes control everything. Today we know that it’s 180 degrees opposite that. It is all about epigenetics. This means we have total control of our DNA if we learn how to use it.
In 2003, the Duke experiments I mentioned in earlier blogs, like CPC #4, they showed that epigenetics is how “conditions of existence” are readily translated in the mammalian clade by acetylation and methylation patterns on their DNA.
Moreover, the evidence on omega 3 marine food consumption was overwhelming. We found in human diets during pregnancy directly affected childhood intelligence and behavior measured at 8 years of age postnatally. This data should act as a constant reminder that H. sapiens is also subject to Darwin’s conditions of existence (Hibbeln et al. 2007).
You rarely hear that in ‘paleo land’. Every mother needs to know that data……what they do and eat primarily determines what kind of brain their child will ultimately have. If it is paleo, it is good, but it is not optimal or close to optimal for a human nervous system. This data shows us that mankind is among the most sensitive mammals to dietary epigenetic influence, whether we choose to believe it or not. What your grandmother and mother does during pregnancy has huge implications for your brain.
Let us look at what is required to make a brain from an evolutionary nutrient perspective.
Given what we learned in Brain Gut-4 we know we need a constant large stable of DHA to keep the brain running optimally. Now let us look further for the evidence of what else we need from a diet and where we find it in abundance and see if there are any connections to be made.
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